Phenotypes associated with this allele

• Allele Symbol: Npy5r^tm1Aka
• Allele Name: targeted mutation 1, Akio Kanantani
• Allele ID: MGI:2158688
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npy5r^tm1Aka/Npy5r^tm1Aka	involves: C57BL/6 * CBA	MGI:3640183

Genotype
MGI:3640183

hm1

• Allelic Composition: Npy5r^tm1Aka/Npy5r^tm1Aka
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased food intake ( J:60632 )

• homozygotes show a reduced orexigenic response to icv injection of moderately selective Y5 agonists [peptide YY (3-36), human pancreatic polypeptide (hPP), and bovine PP] relative to wild-type mice, although food intake is not decreased to vehicle control levels

• however, adult male homozygotes show a normal orexigenic response to icv injection of neuropeptide Y (NPY)

growth/size/body

obese ( J:60632 )

• homozygotes are live-born, fertile and developmentally normal but exhibit slight obesity, in the absence of other abnormalities

increased susceptibility to diet-induced obesity ( J:109457 )

• 12-wk-old male homozygotes fed a moderately high-fat diet for 3-4 weeks gain more weight (8.3 g) than similarly-fed wild-type mice (6.8 g)

• oral administration of a highly selective Y5R antagonist fails to suppress body weight gain in diet-induced obese homozygotes, indicating that the antiobesity effects observed in wild-type mice are Y5R-dependent

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:109457 )

• 12-wk-old male homozygotes fed a moderately high-fat diet for 3-4 weeks gain more weight (8.3 g) than similarly-fed wild-type mice (6.8 g)

• oral administration of a highly selective Y5R antagonist fails to suppress body weight gain in diet-induced obese homozygotes, indicating that the antiobesity effects observed in wild-type mice are Y5R-dependent