Phenotypes associated with this allele

• Allele Symbol: Npy1r^tm1Aka
• Allele Name: targeted mutation 1, Akio Kanatani
• Allele ID: MGI:2158689
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npy1r^tm1Aka/Npy1r^tm1Aka	involves: C57BL/6 * CBA	MGI:3640182

Genotype
MGI:3640182

hm1

• Allelic Composition: Npy1r^tm1Aka/Npy1r^tm1Aka
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal eating behavior ( J:60632 )

• adult male homozygotes display a significantly reduced orexigenic response to icv injection of neuropeptide Y (NPY) relative to wild-type mice

• unexpectedly, homozygotes show a reduced orexigenic response to icv injection of peptide YY (PYY-(3-36)), human pancreatic polypeptide (hPP) and bovine PP (bPP), even though these peptides exhibit low level efficacy at the Y1 receptor based on their binding affinities

growth/size/body

obese ( J:60632 )

• homozygotes are live-born, fertile and developmentally normal but exhibit slight obesity, in the absence of other abnormalities