Analysis Tools
immune system
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• thymus and T cell proliferation in response to TCR stimulation is enhanced in these mice
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• thymus development is delayed in these mice
• thymus morphology at birth is similar to day 13-14 fetal thymus in controls
• the thymus only begins to develop cortical and medullary structures in the first week of life
• between 2-6 of weeks of age, thymus size dramatically increases so that in some cases the thymus is similar in size to controls
• thymic dendritic antigen-presenting-cells are virtually absent
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• thymocyte number is low at birth but increases with age
• thymocyte numbers are 100- to 300- fold lower than controls between 3 and 6 days of age
• numbers increase between 2 and 6 weeks after birth so that thymocyte numbers range from 5- fold lower to normal
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• pro-B cells are absent in the bone marrow
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• fetal T cell development is severely impaired leading to a defect in gamma-delta intraepithelial lymphocyte development
(J:37317)
• mice exhibit skewing towards the CD4+ lineage
(J:208211)
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• double-positive thymocyte numbers are decreased in these mice
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• granulocyte numbers in the bone marrow are decreased compared to control
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• thymic dendritic antigen-presenting-cells are virtually absent
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• absent
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• B-1a B cells are absent in the peritoneum
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• B cells are absent in the periphery
(J:37317)
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• pre-B cells are absent in the bone marrow
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• NK cells are absent in the spleen
(J:37317)
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• no significant gamma-delta T cell population is found in the spleen
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• mice lack dendritic epidermal T cells in the skin
• intraepithelial gamma-delta T cell numbers in the intestine are severely reduced
• vagina mucosal gamma-delta T cell numbers are normal
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• ratio of CD4+ to CD8+ T cells varies from being similar to wild-type to being increased by 2- to 3- fold
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• splenocyte numbers are low at birth but increase with age
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• Peyer's patches lymphoid follicles are absent in these mice
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hematopoietic system
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• thymus and T cell proliferation in response to TCR stimulation is enhanced in these mice
|
|
• thymus development is delayed in these mice
• thymus morphology at birth is similar to day 13-14 fetal thymus in controls
• the thymus only begins to develop cortical and medullary structures in the first week of life
• between 2-6 of weeks of age, thymus size dramatically increases so that in some cases the thymus is similar in size to controls
• thymic dendritic antigen-presenting-cells are virtually absent
|
|
• thymocyte number is low at birth but increases with age
• thymocyte numbers are 100- to 300- fold lower than controls between 3 and 6 days of age
• numbers increase between 2 and 6 weeks after birth so that thymocyte numbers range from 5- fold lower to normal
|
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• the abnormal erythropoiesis associated with mice homozygote for the dominant-negative Ikzf1tm1Kge allele are not observed in these mice
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• pro-B cells are absent in the bone marrow
|
|
• fetal T cell development is severely impaired leading to a defect in gamma-delta intraepithelial lymphocyte development
(J:37317)
• mice exhibit skewing towards the CD4+ lineage
(J:208211)
|
|
• double-positive thymocyte numbers are decreased in these mice
|
|
• granulocyte numbers in the bone marrow are decreased compared to control
|
|
• thymic dendritic antigen-presenting-cells are virtually absent
|
|
• absent
|
|
• B-1a B cells are absent in the peritoneum
|
|
• B cells are absent in the periphery
(J:37317)
|
|
• pre-B cells are absent in the bone marrow
|
|
• NK cells are absent in the spleen
(J:37317)
|
|
• no significant gamma-delta T cell population is found in the spleen
|
|
• mice lack dendritic epidermal T cells in the skin
• intraepithelial gamma-delta T cell numbers in the intestine are severely reduced
• vagina mucosal gamma-delta T cell numbers are normal
|
|
• ratio of CD4+ to CD8+ T cells varies from being similar to wild-type to being increased by 2- to 3- fold
|
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• splenocyte numbers are low at birth but increase with age
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endocrine/exocrine glands
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• thymus development is delayed in these mice
• thymus morphology at birth is similar to day 13-14 fetal thymus in controls
• the thymus only begins to develop cortical and medullary structures in the first week of life
• between 2-6 of weeks of age, thymus size dramatically increases so that in some cases the thymus is similar in size to controls
• thymic dendritic antigen-presenting-cells are virtually absent
|
|
• thymocyte number is low at birth but increases with age
• thymocyte numbers are 100- to 300- fold lower than controls between 3 and 6 days of age
• numbers increase between 2 and 6 weeks after birth so that thymocyte numbers range from 5- fold lower to normal
|
cellular
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• thymus and T cell proliferation in response to TCR stimulation is enhanced in these mice
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