Phenotypes associated with this allele

• Allele Symbol: Men1^tm1.1Ctre
• Allele Name: targeted mutation 1.1, Judy S Crabtree
• Allele ID: MGI:2158698
• Summary: 9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Men1^tm1.1Ctre/Men1^tm1.1Ctre	either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)	MGI:3839762
ht2	Men1^tm1.1Ctre/Men1^+	either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)	MGI:3839763
ht3	Men1^tm1.1Ctre/Men1^+	involves: 129S6/SvEvTac * C57BL/6	MGI:3839783
ht4	Men1^tm1.1Ctre/Men1^+	involves: 129S6/SvEvTac * FVB/N	MGI:3839770
cx5	Cdkn1b^tm1Ako/Cdkn1b^tm1Ako Men1^tm1.1Ctre/Men1^+	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	MGI:3839788
cx6	Cdkn1b^tm1Ako/Cdkn1b^tm1Ako Men1^tm1.1Ctre/Men1^tm1.1Ctre	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	MGI:3839789
cx7	Men1^tm1.1Ctre/Men1^+ Rb1^tm1Tyj/Rb1^+	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:3839773
cx8	Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Men1^tm1.1Ctre/Men1^+	involves: 129/Sv * 129S6/SvEvTac * C57BL/6	MGI:3839785
cx9	Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi Men1^tm1.1Ctre/Men1^tm1.1Ctre	involves: 129/Sv * 129S6/SvEvTac * C57BL/6	MGI:3839786

Genotype
MGI:3839762

hm1

• Allelic Composition: Men1^tm1.1Ctre/Men1^tm1.1Ctre
• Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:67128 )

• mice die at E10.5 to E11.5

Genotype
MGI:3839763

ht2

• Allelic Composition: Men1^tm1.1Ctre/Men1⁺
• Genetic Background: either: (involves: 129S6/SvEvTac * FVB/N) or (involves: 129S6/SvEvTac * Black Swiss * FVB/N)

neoplasm

increased pancreas tumor incidence ( J:67128 )

• after 9 months, 83% of mice develop pancreatic islet tumors unlike wild-type mice

• pancreatic tumors begin at a slightly earlier age than in Men1^tm1Ctre heterozygotes

endocrine/exocrine glands

pancreatic islet hyperplasia ( J:67128 )

increased pancreas tumor incidence ( J:67128 )

• after 9 months, 83% of mice develop pancreatic islet tumors unlike wild-type mice

• pancreatic tumors begin at a slightly earlier age than in Men1^tm1Ctre heterozygotes

Genotype
MGI:3839783

ht3

• Allelic Composition: Men1^tm1.1Ctre/Men1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

neoplasm

increased gland tumor incidence ( J:120835 )

• mice develop tumors of the pituitary, thyroid, parathyroid, pancreas, adrenal and testis

increased adrenal gland tumor incidence ( J:120835 )

increased pituitary gland tumor incidence ( J:120835 )

increased parathyroid gland tumor incidence ( J:120835 )

increased thyroid tumor incidence ( J:120835 )

increased pancreas tumor incidence ( J:120835 )

increased testis tumor incidence ( J:120835 )

♂

increased lung adenocarcinoma incidence ( J:120835 )

• lung adenomcarcinomas develop in 42% of mice including 2 neuroendocrine carcinomas

• tumors have several nodules and individual nodules consisting of more than one tumor cell type with blurred or disrupted borders

• bronchioalveolar stem cells are expanded in lung tumors

respiratory system

increased lung adenocarcinoma incidence ( J:120835 )

• lung adenomcarcinomas develop in 42% of mice including 2 neuroendocrine carcinomas

• tumors have several nodules and individual nodules consisting of more than one tumor cell type with blurred or disrupted borders

• bronchioalveolar stem cells are expanded in lung tumors

endocrine/exocrine glands

increased gland tumor incidence ( J:120835 )

• mice develop tumors of the pituitary, thyroid, parathyroid, pancreas, adrenal and testis

increased adrenal gland tumor incidence ( J:120835 )

increased pituitary gland tumor incidence ( J:120835 )

increased parathyroid gland tumor incidence ( J:120835 )

increased thyroid tumor incidence ( J:120835 )

increased pancreas tumor incidence ( J:120835 )

increased testis tumor incidence ( J:120835 )

♂

reproductive system

increased testis tumor incidence ( J:120835 )

♂

nervous system

increased pituitary gland tumor incidence ( J:120835 )

Genotype
MGI:3839770

ht4

• Allelic Composition: Men1^tm1.1Ctre/Men1⁺
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

neoplasm

increased adrenal gland tumor incidence ( J:133299 )

• mice exhibit adrenal cortical tumors (28%)

increased pheochromocytoma incidence ( J:133299 )

• in 44% of mice

increased pituitary adenohypophysis tumor incidence ( J:133299 )

• mice exhibit pituitary anterior lobe tumors (81%)

increased parathyroid adenoma incidence ( J:133299 )

• 61% of mice exhibit parathyroid adenomas

increased pancreatic islet cell adenoma incidence ( J:133299 )

• 57% of mice exhibit pancreatic islet adenomas

increased lung tumor incidence ( J:133299 )

• 6% of mice exhibit lung metastasis

respiratory system

increased lung tumor incidence ( J:133299 )

• 6% of mice exhibit lung metastasis

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:133299 )

• mice exhibit adrenal cortical tumors (28%)

increased pheochromocytoma incidence ( J:133299 )

• in 44% of mice

increased pituitary adenohypophysis tumor incidence ( J:133299 )

• mice exhibit pituitary anterior lobe tumors (81%)

increased parathyroid adenoma incidence ( J:133299 )

• 61% of mice exhibit parathyroid adenomas

increased pancreatic islet cell adenoma incidence ( J:133299 )

• 57% of mice exhibit pancreatic islet adenomas

nervous system

increased pituitary adenohypophysis tumor incidence ( J:133299 )

• mice exhibit pituitary anterior lobe tumors (81%)

Genotype
MGI:3839788

cx5

• Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako; Men1^tm1.1Ctre/Men1⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

neoplasm

increased tumor incidence ( J:120835 )

• mice develop tumors of the pituitary, thyroid, parathyroid, pancreas, adrenal and testis

increased adrenal gland tumor incidence ( J:120835 )

increased pituitary gland tumor incidence ( J:120835 )

increased parathyroid gland tumor incidence ( J:120835 )

increased thyroid tumor incidence ( J:120835 )

increased pancreas tumor incidence ( J:120835 )

increased testis tumor incidence ( J:120835 )

♂

increased lung adenoma incidence ( J:120835 )

• in 6 % of mice

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:120835 )

increased pituitary gland tumor incidence ( J:120835 )

increased parathyroid gland tumor incidence ( J:120835 )

increased thyroid tumor incidence ( J:120835 )

increased pancreas tumor incidence ( J:120835 )

increased testis tumor incidence ( J:120835 )

♂

reproductive system

increased testis tumor incidence ( J:120835 )

♂

nervous system

increased pituitary gland tumor incidence ( J:120835 )

respiratory system

increased lung adenoma incidence ( J:120835 )

• in 6 % of mice

Genotype
MGI:3839789

cx6

• Allelic Composition: Cdkn1b^tm1Ako/Cdkn1b^tm1Ako; Men1^tm1.1Ctre/Men1^tm1.1Ctre
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

mortality/aging

embryonic lethality, complete penetrance ( J:120835 )

• no viable double homozygous embryos were present beyond E15.5

Genotype
MGI:3839773

cx7

• Allelic Composition: Men1^tm1.1Ctre/Men1⁺; Rb1^tm1Tyj/Rb1⁺
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N

mortality/aging

premature death ( J:133299 )

• median lifespan is 402 days compared to 546 days for Men1^tm1.1Ctre heterozygotes

neoplasm

increased adrenal gland tumor incidence ( J:133299 )

• adrenal cortical tumor (10% of mice)

increased pheochromocytoma incidence ( J:133299 )

• in 45% of mice

increased pituitary adenohypophysis tumor incidence ( J:133299 )

• mice exhibit pituitary anterior lobe tumors (40% of mice)

increased pituitary melanotroph tumor incidence ( J:133299 )

• pituitary intermediate lobe tumors (96% of mice)

increased parathyroid gland tumor incidence ( J:133299 )

• 50% of mice exhibit parathyroid gland tumors

increased thyroid C-cell carcinoma incidence ( J:133299 )

• mice exhibit thyroid C-cell carcinomas (96%)

increased pancreas tumor incidence ( J:133299 )

• 55% of mice exhibit pancreatic islet tumors

increased metastatic potential ( J:133299 )

• metastasis in the lungs (70% of mice)

nervous system

increased pituitary adenohypophysis tumor incidence ( J:133299 )

• mice exhibit pituitary anterior lobe tumors (40% of mice)

increased pituitary melanotroph tumor incidence ( J:133299 )

• pituitary intermediate lobe tumors (96% of mice)

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:133299 )

• adrenal cortical tumor (10% of mice)

increased pheochromocytoma incidence ( J:133299 )

• in 45% of mice

increased pituitary adenohypophysis tumor incidence ( J:133299 )

• mice exhibit pituitary anterior lobe tumors (40% of mice)

increased pituitary melanotroph tumor incidence ( J:133299 )

• pituitary intermediate lobe tumors (96% of mice)

increased parathyroid gland tumor incidence ( J:133299 )

• 50% of mice exhibit parathyroid gland tumors

increased thyroid C-cell carcinoma incidence ( J:133299 )

• mice exhibit thyroid C-cell carcinomas (96%)

increased pancreas tumor incidence ( J:133299 )

• 55% of mice exhibit pancreatic islet tumors

Genotype
MGI:3839785

cx8

• Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi; Men1^tm1.1Ctre/Men1⁺
• Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

neoplasm

increased adrenal gland tumor incidence ( J:120835 )

increased parathyroid gland tumor incidence ( J:120835 )

increased thyroid tumor incidence ( J:120835 )

increased pancreas tumor incidence ( J:120835 )

increased testis tumor incidence ( J:120835 )

♂ • some mice exhibit Leydig cell adenocarcinomas

increased Leydig cell tumor incidence ( J:120835 )

♂ • some mice exhibit Leydig cell adenocarcinomas

increased adenocarcinoma incidence ( J:120835 )

• some mice exhibit Leydig cell adenocarcinomas

increased lung tumor incidence ( J:120835 )

• most lung tumors are primary

• bronchioalveolar stem cells are expanded in lung tumors compared to in Cdkn2c^tm1Yxi homozygotes or Men1^tm1.1Ctre heterozygotes

increased lung adenoma incidence ( J:120835 )

• in 33% of mice before 1 year of age

increased lung adenocarcinoma incidence ( J:120835 )

• after 1 year of age, lung adenocarcinomas develop in 63% of mice including 3 carcinomas with neuroendocrine characteristics

• mice develop multiple lung carcinomas that are more aggressive and invasive than in single mutant mice

• neuroendocrine carcinomas are more proliferative and apoptotic than in single mutant mice

decreased tumor latency ( J:120835 )

• tumors develop quicker than in Men1^tm1.1Ctre heterozygotes

reproductive system

increased testis tumor incidence ( J:120835 )

♂ • some mice exhibit Leydig cell adenocarcinomas

increased Leydig cell tumor incidence ( J:120835 )

♂ • some mice exhibit Leydig cell adenocarcinomas

respiratory system

increased lung tumor incidence ( J:120835 )

• most lung tumors are primary

• bronchioalveolar stem cells are expanded in lung tumors compared to in Cdkn2c^tm1Yxi homozygotes or Men1^tm1.1Ctre heterozygotes

increased lung adenoma incidence ( J:120835 )

• in 33% of mice before 1 year of age

increased lung adenocarcinoma incidence ( J:120835 )

• after 1 year of age, lung adenocarcinomas develop in 63% of mice including 3 carcinomas with neuroendocrine characteristics

• mice develop multiple lung carcinomas that are more aggressive and invasive than in single mutant mice

• neuroendocrine carcinomas are more proliferative and apoptotic than in single mutant mice

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:120835 )

increased parathyroid gland tumor incidence ( J:120835 )

increased thyroid tumor incidence ( J:120835 )

increased pancreas tumor incidence ( J:120835 )

increased testis tumor incidence ( J:120835 )

♂ • some mice exhibit Leydig cell adenocarcinomas

increased Leydig cell tumor incidence ( J:120835 )

♂ • some mice exhibit Leydig cell adenocarcinomas

Genotype
MGI:3839786

cx9

• Allelic Composition: Cdkn2c^tm1Yxi/Cdkn2c^tm1Yxi; Men1^tm1.1Ctre/Men1^tm1.1Ctre
• Genetic Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6

mortality/aging

embryonic lethality, complete penetrance ( J:120835 )

• no viable double homozygous embryos were present beyond E15.5