Phenotypes associated with this allele

• Allele Symbol: Npy1r^tm1Mnak
• Allele Name: targeted mutation 1, Motonao Nakamura
• Allele ID: MGI:2158702
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npy1r^tm1Mnak/Npy1r^tm1Mnak	involves: 129P2/OlaHsd * C57BL/6	MGI:3845890

Genotype
MGI:3845890

hm1

• Allelic Composition: Npy1r^tm1Mnak/Npy1r^tm1Mnak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:51684 )

• begin to gain weight faster beginning around 9 weeks of age

• females weigh significantly more than control females at 24 weeks of age

homeostasis/metabolism

increased circulating insulin level ( J:51684 )

• moderate hyperinsulinemia in both males and females

decreased energy expenditure ( J:51684 )

• when placed on a food intake restricted diet the rate of weight loss is reduced compared to similarly treated wild-type mice

impaired glucose tolerance ( J:51684 )

• administration of a 30% glucose solution fails to significantly alter serum insulin levels unlike similarly treated wild-type mice

adipose tissue

increased gonadal fat pad weight ( J:51684 )

• increased ovarian fat pad weight at 31 weeks of age

increased retroperitoneal fat pad weight ( J:51684 )

• in females but not males at 31 weeks of age

behavior/neurological

behavior/neurological phenotype ( J:51684 )

N • despite increased body weight, no increase in food intake is detected