All Phenotypes C3<tm1Hrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

C3^tm1Hrc
targeted mutation 1, Harvey R Colten
MGI:2158703

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C3^tm1Hrc/C3^tm1Hrc	B6.129-C3^tm1Hrc	MGI:3505869
hm2	C3^tm1Hrc/C3^tm1Hrc	either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129X1/SvJ * C57BL/6)	MGI:2449063
hm3	C3^tm1Hrc/C3^tm1Hrc	involves: 129	MGI:3505862
hm4	C3^tm1Hrc/C3^tm1Hrc	involves: 129/Sv * C57BL/6	MGI:3505857
cx5	C3^tm1Hrc/C3^tm1Hrc Lama2^dy/Lama2^dy	either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)	MGI:3789477
cx6	C3^tm1Hrc/C3^tm1Hrc Cfh^tm1.1Song/Cfh^tm1.1Song	involves: 129 * C57BL/6	MGI:6314832
cx7	C3^tm1Hrc/C3^tm1Hrc Lep^ob/Lep^ob	involves: 129 * C57BL/6	MGI:3505871
cx8	C3^tm1Hrc/C3^tm1Hrc Cd55^tm1Song/Cd55^tm1Song Cr1l^tm1Hmo/Cr1l^tm1Hmo	involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ	MGI:3806100
cx9	C3^tm1Hrc/C3^tm1Hrc Cd55^tm1Song/Cd55^tm1Song Cr1l^tm1Hmo/Cr1l^tm1Hmo Vsig4^tm1Gne/Vsig4^tm1Gne	involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N	MGI:3806101
cx10	C3^tm1Hrc/C3^tm1Hrc Cr1l^tm1Hmo/Cr1l^tm1Hmo	involves: 129/Sv * 129X1/SvJ * C57BL/6	MGI:3505876
cx11	C3^tm1Hrc/C3^tm1Hrc Vsig4^tm1Gne/Vsig4^tm1Gne	involves: 129/Sv * C57BL/6N	MGI:3806098

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc
Genetic Background	B6.129-C3^tm1Hrc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

impaired liver regeneration ( J:91917 )

• hepatocyte proliferation is reduced and removal of necrotic and apoptotic cells is impaired after CCl₄ treatment

immune system

impaired complement alternative pathway ( J:177350 )

• mice treated with collagen antibodies do not exhibit C43 or C5a depositions compared unlike similarly treated wild-type mice

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc
Genetic Background	either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129X1/SvJ * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:56193 )

• a 2000-fold increase in pneumococci is seen compared to wild-type littermates following infection with S. pneumoniae

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
complement component 3 deficiency		DOID:8354	OMIM:613779	J:56193

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:87945 )

behavior/neurological

polyphagia ( J:87945 )

• mutants consume 30% more calories compared to wild-type mice

digestive/alimentary system

abnormal intestinal lipid absorption ( J:87945 )

• muscle and liver uptake of labeled oleate is increased after fat loading however brown adipose tissue oleate uptake is decreased

growth/size/body

decreased body weight ( J:87945 )

homeostasis/metabolism

abnormal intestinal lipid absorption ( J:87945 )

• muscle and liver uptake of labeled oleate is increased after fat loading however brown adipose tissue oleate uptake is decreased

decreased circulating insulin level ( J:87945 )

• insulin levels are decreased relative to glucose compared to wild-type mice

decreased circulating leptin level ( J:87945 )

increased circulating free fatty acids level ( J:87945 )

• in males non-esterified fatty acid clearance is delayed relative to wild-type mice after fat administration

increased triglyceride level ( J:87945 )

• triglyceride clearance is delayed in mutants backcrossed onto a 129/Sv background but not a C57BL/6 background

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased brown adipose tissue amount ( J:58966 )

• a significant increase in capsular BAT is seen on high and low fat diets in male mutants compared to wild-type

decreased white adipose tissue amount ( J:60633 )

• on a high or low fat diet female mutants have decreased white adipose tissue

decreased total body fat amount ( J:58966 , J:60633 )

	• on a high or low fat diet total body fat is decreased by 40% or 59%, respectively, in female mutants (J:60633)
	• a small but significant decrease in adipose tissue mass particularly in the gonadal and perirenal fat is seen in male mutants (J:58966)

behavior/neurological

polyphagia ( J:58966 , J:60633 )

	• on a high fat diet a marked increase in food intake is seen in female mutants compared to wild-type littermates (J:60633)
	• mild polyphagia is seen in male mutants (J:58966)

growth/size/body

decreased body weight ( J:60633 )

• on a high or low fat diet female mutants weigh less than wild-type littermates

homeostasis/metabolism

decreased circulating leptin level ( J:58966 , J:60633 )

	• on a high or low fat diet, relative to body weight leptin levels are reduced in female mutants (J:60633)
	• relative to body weight leptin levels are reduced in male mutants (J:58966)

abnormal energy expenditure ( J:58966 , J:60633 )

	• male mutants require a greater caloric intake relative to body weight gained compared to wild-type littermates (J:58966)
	• the average calorie intake/g increase in body weight is greater in female mutants on either a high or low fat diet (J:60633)

abnormal glucose homeostasis ( J:58966 , J:60633 )

decreased circulating glucose level ( J:58966 , J:60633 )

	• glucose levels and the glucose level for any given insulin level are significantly decreased in female mutants (J:60633)
	• at any given insulin level the corresponding glucose level is significantly lower in male mutants compared to wild-type on a high fat diet (J:58966)

decreased circulating insulin level ( J:60633 )

• insulin levels are significantly decreased in female mutants

abnormal lipid homeostasis ( J:58966 , J:60633 )

increased circulating free fatty acids level ( J:58966 , J:60633 )

	• postprandial but not fasting non-esterified fatty acid levels are increased in female mutants especially at 26 weeks of age (J:60633)
	• on a high fat diet postprandial plasma non-esterified fatty acid levels are increased 2.5 fold compared to male mutants on a low fat diet and no such increase was seen in wild-type littermates (J:58966) • after 4 months on a low fat or high fat diet a greater increase in non-esterified fatty acid levels is seen in male mutants compared to wild-type mice (J:58966)

decreased circulating triglyceride level ( J:60633 )

• on either a high or low fat diet postprandial triglyceride levels are reduced in female mutants compared to wild-type littermates

increased triglyceride level ( J:58966 )

• an 80% increase in triglyceride levels compared to wild-type mice is seen in male mutants after eating (postprandial)

• a larger increase in triglyceride levels is seen in male mutants compared to wild-type littermates after 4 months on a low fat diet but not on a high fat diet

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc Lama2^dy/Lama2^dy
Genetic Background	either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (103 available)
Lama2^dy mutation (2 available); any Lama2 mutation (177 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:102959 )

• 86% of mice survive the 24 week experiment compared to only 66% of Lama2^dy homozygotes

muscle

abnormal skeletal muscle morphology ( J:102959 )

• fewer macrophages are found within muscles compared to in Lama2^dy homozygotes

skeletal muscle interstitial fibrosis ( J:102959 )

dystrophic muscle ( J:102959 )

behavior/neurological

abnormal physical strength ( J:102959 )

• mice exhibit 25% to 20% greater forelimb strength than Lama2^dy homozygotes

growth/size/body

increased body weight ( J:102959 )

• compared to Lama2^dy homozygotes

immune system

increased IgG level ( J:102959 )

• mice exhibit increased deposition of IgG in muscles compared to in wild-type mice

decreased IgM level ( J:102959 )

• mice exhibit reduce deposition of IgM in muscles compared to in Lama2^dy homozygotes

increased IgM level ( J:102959 )

• mice exhibit increased deposition of IgM in muscles compared to in wild-type mice

hematopoietic system

increased IgG level ( J:102959 )

• mice exhibit increased deposition of IgG in muscles compared to in wild-type mice

decreased IgM level ( J:102959 )

• mice exhibit reduce deposition of IgM in muscles compared to in Lama2^dy homozygotes

increased IgM level ( J:102959 )

• mice exhibit increased deposition of IgM in muscles compared to in wild-type mice

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc Cfh^tm1.1Song/Cfh^tm1.1Song
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (103 available)
Cfh^tm1.1Song mutation (0 available); any Cfh mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:240426 )

• mice live normally, with none developing stroke symptoms and normal BUN, platelet and hemoglobin levels, no evidence of renal pathology or thrombus formation, and normal retina and retinal blood flow

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc Lep^ob/Lep^ob
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (103 available)
Lep^ob mutation (5 available); any Lep mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

polyphagia ( J:80546 )

• polyphagia is seen compared to Lep^ob homozygotes

growth/size/body

decreased body weight ( J:80546 )

• double knock outs have decreased body weight compared to Lep^ob homozygotes

homeostasis/metabolism

abnormal energy expenditure ( J:80546 )

• the average calorie intake/g increase in body weight is greater in double homozygotes compared to Lep^ob homozygotes

abnormal oxygen consumption ( J:80546 )

• oxygen consumption is increased relative to Lep^ob homozygotes and about the same as wild-type mice

abnormal glucose homeostasis ( J:80546 )

decreased circulating insulin level ( J:80546 )

• insulin levels are decreased compared to Lep^ob homozygotes

abnormal lipid homeostasis ( J:80546 )

increased circulating free fatty acids level ( J:80546 )

• postprandial non-esterified fatty acid levels are increased compared to Lep^ob homozygotes and wild-type mice

increased triglyceride level ( J:80546 )

• postprandial triglyceride clearance is delayed in both males and females

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc Cd55^tm1Song/Cd55^tm1Song Cr1l^tm1Hmo/Cr1l^tm1Hmo
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (103 available)
Cd55^tm1Song mutation (2 available); any Cd55 mutation (39 available)
Cr1l^tm1Hmo mutation (0 available); any Cr1l mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal platelet physiology ( J:138410 )

• transplanted platelets exhibit a decreased half-life compared to wild-type platelets that is complement and macrophage dependent

• however, transgenic expression of Cd55 rescues platelet half-life following transplantation

homeostasis/metabolism

abnormal platelet physiology ( J:138410 )

• transplanted platelets exhibit a decreased half-life compared to wild-type platelets that is complement and macrophage dependent

• however, transgenic expression of Cd55 rescues platelet half-life following transplantation

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc Cd55^tm1Song/Cd55^tm1Song Cr1l^tm1Hmo/Cr1l^tm1Hmo Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal platelet physiology ( J:138410 )

• unlike in C3^tm1Hrc Cd55^tm1Song Cr1l^tm1Hmo homozygotes, platelet half-life is normal

homeostasis/metabolism

abnormal platelet physiology ( J:138410 )

• unlike in C3^tm1Hrc Cd55^tm1Song Cr1l^tm1Hmo homozygotes, platelet half-life is normal

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc Cr1l^tm1Hmo/Cr1l^tm1Hmo
Genetic Background	involves: 129/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (103 available)
Cr1l^tm1Hmo mutation (0 available); any Cr1l mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:59432 )

N	• survival of double homozygotes is normal

immune system

abnormal complement pathway ( J:76578 )

• erythrocytes show slightly increased susceptibility to antibody-induced lysis by human, but not by rat, complement compared to wild-type

• antibody-sensitized erythrocytes exhibit increased C3 deposition compared to wild-type cells

• mutant erythrocytes transfused into wild-type mice are more rapidly eliminated than controls indicating increased susceptibility to spontaneous complement attack in vivo, however cells are protected from removal when transfused to C3 deficient mice

reproductive system

reproductive system phenotype ( J:86999 )

N	• when mating double homozygous females to Crry^tm1Hmo heterozygous males the expected number of pups of both possible genotypes are seen unlike in the reverse situation when fewer than expected Crry^tm1Hmo homozygous pups are found

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	involves: 129/Sv * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (103 available)
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:138691 )

N	• following infection with Staphylococcus aureus, bacterial counts are normal

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