Analysis Tools|
Allele Symbol Allele Name Allele ID |
Chrnb4tm1Mdb targeted mutation 1, Mariella De Biasi MGI:2158716 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• less sensitivity to nicotine-induced seizures than wild-type controls or Chrna5tm1Mdb/tm1Mdb mice
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• less sensitivity to nicotine-induced seizures than wild-type controls or Chrna5tm1Mdb/tm1Mdb mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• focal hyperplasia or dysplasia is noted in 3 of 4 animals and mitotic activity in 2 of 4 animals
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• in response to nicotine, contraction in bladder strips was greatly reduced whereas contraction was easily induced in controls
(J:73590)
• contractile responses to nicotine in bladder strips from 2- to 5-day-old mutant mice are severely attenuated, despite the absence of bladder distension and
urine retention phenotype seen in Chrna3 mutant mice
(J:102601)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• less sensitive to nicotine-induced seizures than wild-type controls or single homozygous mutant mice
• latency time to seizure is significantly shorter than in wild-type
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• less sensitive to nicotine-induced seizures than wild-type controls or single homozygous mutant mice
• latency time to seizure is significantly shorter than in wild-type
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most homozygous animals die within 10 days of birth and the remainder die by 3 weeks of age
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• delayed opening and flattening of the ears after birth
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• growth is significantly impaired compared to controls
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| N |
• blood chemistry measurments for glucose, electrolytes, phosphate, calcium, magnesium, urea nitrogen, creatinine, alanine aminotransferase, aspartate aminotransferase, and bilirubin are similar to controls
• urine chemistry measurments for glucose, electrolytes, phosphate, calcium, magnesium, and creatinine are similar to controls
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• inflamed urinary bladder
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• urine is sometimes cloudy with a dense accumulation of bacteria and white blood cells
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• no contraction in response to light
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| N |
• smooth muscle contraction in the urinary bladder can be induced with the muscarinic agonist CCH suggesting normal muscle function
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• reduced intestinal motility
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• profiles of current recordings from nicotine-elicited superior cervial ganglion neurons show no that nicotine does not elicit inward currents at any concentration tested, wheras robust inward currents are seen in controls
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• profiles of current recordings from nicotine-elicited superior cervial ganglion neurons show no that nicotine does not elicit inward currents at any concentration tested, wheras robust inward currents are seen in controls
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• necrotic mucosa observed in 3 of 4 mice examined
• bladder mucosa was dysplastic with malignant characteristics in 2 of 4 mice examined
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• in older animals, the bladder often contains numerous urinary stones
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• distended bladders are seen in 3 of 7 mice
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• nicotine failed to elicit contraction in bladder strips whereas contraction was easily induced in controls
(J:73590)
• contractile responses to nicotine in bladder strips from 2- to 5-day-old mutant mice are severely attenuated
(J:102601)
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• inflamed urinary bladder
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• wetness of the genital area is noted; chronic urinary dribbling is observed throughout life
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• no contraction in response to light
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• small palpebral fissures
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• eyes remain closed after postnatal day 15
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• delayed opening and flattening of the ears after birth
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• delayed opening and flattening of the ears after birth
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• reduced intestinal motility
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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