All Phenotypes Gli2<tm3(Gli1)Alj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gli2^tm3(Gli1)Alj
targeted mutation 3, Alexandra L Joyner
MGI:2158719

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gli2^tm3(Gli1)Alj/Gli2^tm3(Gli1)Alj	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:3846350
hm2	Gli2^tm3(Gli1)Alj/Gli2^tm3(Gli1)Alj	involves: 129S6/SvEvTac * Black Swiss * Swiss Webster	MGI:3795686
ht3	Gli2^tm2.1Alj/Gli2^tm3(Gli1)Alj	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:3846348
cx4	Gli2^tm3(Gli1)Alj/Gli2^tm3(Gli1)Alj Gli3^Xt-J/Gli3⁺	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster	MGI:3795687

Allelic Composition	Gli2^tm3(Gli1)Alj/Gli2^tm3(Gli1)Alj
Genetic Background	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm3(Gli1)Alj mutation (0 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:73074 )

• most mice that survive past weaning die by 3 months of age

postnatal lethality, incomplete penetrance ( J:73074 )

• fewer than expected mice are found at weaning

growth/size/body

decreased body size ( J:73074 )

• about 40% smaller than controls by 3 months of age

behavior/neurological

impaired limb coordination ( J:73074 )

• impaired hindlimb coordination is seen at 3 months of age

bradykinesia ( J:73074 )

• stiffness in the hindlimbs is seen at 3 months of age

integument

progressive hair loss ( J:73074 )

• loss of hair beginning on the dorsal neck

• hair loss is more severe than in mice carrying Gli2^{tm3.1(Gli2)Alj} and Gli2^tm2.1Alj

Allelic Composition	Gli2^tm3(Gli1)Alj/Gli2^tm3(Gli1)Alj
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm3(Gli1)Alj mutation (0 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:112460 )

N	• embryos show normal mammary gland development

Allelic Composition	Gli2^tm2.1Alj/Gli2^tm3(Gli1)Alj
Genetic Background	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm2.1Alj mutation (1 available); any Gli2 mutation (169 available)
Gli2^tm3(Gli1)Alj mutation (0 available); any Gli2 mutation (169 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:73074 )

• viable with no gross abnormalities

• unlike in homozygous null mice, at E10.5 the floor plate is present, interneurons are found in the appropriate location, and notochord regression is normal

• unlike in homozygous null mice, at E12.5 lung size is normal and the accessory lobe is present

Allelic Composition	Gli2^tm3(Gli1)Alj/Gli2^tm3(Gli1)Alj Gli3^Xt-J/Gli3⁺
Genetic Background	involves: 129S6/SvEvTac * Black Swiss * C3H/HeJ * C57BL/6 * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli2^tm3(Gli1)Alj mutation (0 available); any Gli2 mutation (169 available)
Gli3^Xt-J mutation (3 available); any Gli3 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland bud morphology ( J:112460 )

• most embryos lack mammary bud pair number 3 and number 5

integument

abnormal mammary gland bud morphology ( J:112460 )

• most embryos lack mammary bud pair number 3 and number 5

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