Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gli2tm3.1(Gli1)Alj targeted mutation 3.1, Alexandra L Joyner MGI:2158720 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mice are found at weaning
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| N |
• unlike in homozygous null mice, differentiation of floor plate, ventral interneurons and motor neurons is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• gradual loss of hair beginning on the dorsal neck and preceding caudally down the back in mice over 3 weeks of age
• around 5 months of age mice lack hair around the neck
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike in homozygous null mice, at E10.5 the floor plate is present, interneurons are found in the appropriate location, and notochord regression is normal
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| N |
• unlike in homozygous null mice, at E12.5 lung size is normal and the accessory lobe is present
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• gradual loss of hair beginning on the dorsal neck and preceding caudally down the back in mice over 3 weeks of age
• around 5 months of age mice lack hair around the neck
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E10.5
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• in about half of mice development of the diencephalic vesicles is partially rescued with partial separation into 2 vesicles seen at E10.5 or E11.5
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• absent from the spinal cord at E10.5
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• absence of V3 interneurons at E10.5
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• at E10.5
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• head size is increased compared to mice homozygous null for Shh alone
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• females die by 6 weeks of age
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• polydactyl is enhanced compared to mice heterozygous for Gli3Xt-J alone
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• all males are sterile
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• hair loss is more severe compared to mice heterozygous for Gli2tm3.1(Gli2)Alj alone
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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