Phenotypes associated with this allele

• Allele Symbol: Camk2a^tm2Sva
• Allele Name: targeted mutation 2, Alcino Silva
• Allele ID: MGI:2158733
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk2a^tm2Sva/Camk2a^tm2Sva	B6.129P2-Camk2a^tm2Sva	MGI:3764508
hm2	Camk2a^tm2Sva/Camk2a^tm2Sva	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3764491

Genotype
MGI:3764508

hm1

• Allelic Composition: Camk2a^tm2Sva/Camk2a^tm2Sva
• Genetic Background: B6.129P2-Camk2a^tm2Sva

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dendrite morphology ( J:116531 )

• the number of dendritic branches is increased (26.3+/-4 compared to 16.7+/-2 in wild-type mice)

• dendritic length is increased (1599+/-174 um compared to 1132+/-100 um in wild-type mice)

• however, the diameter of the cell body, the number of primary dendrites emanating from the soma and total dorsoventral and rostrocaudal extents are normal

abnormal cutaneous/subcutaneous mechanoreceptor morphology ( J:116531 )

• cutaneous receptive field size is increased (3593+/-615 compared to 2215+/-223 in wild-type mice)

abnormal excitatory postsynaptic currents ( J:116531 )

• LT cells of the dorsal root require increased stimulation to produce an excitatory postsynaptic current (300+/-26 uA, 50 us compared to 217+/-17 uA, 50 us for wild-type mice)

integument

abnormal skin condition ( J:116531 )

• mice exhibit a decrease in sensitivity to mechanical skin stimulation (0.76+/-0.1 g compared to 0.42+/-0.1 g in wild-type mice)

Genotype
MGI:3764491

hm2

• Allelic Composition: Camk2a^tm2Sva/Camk2a^tm2Sva
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

nervous system phenotype ( J:127397 )

N • unlike in Camk2a^tm2Sva homozygotes, field excitatory postsynaptic potential and synaptic plasticity are normal

reduced long-term potentiation ( J:127397 )

• long term potentiation is absent

absent long-term depression ( J:208776 )

• no significant low-frequency stimulation-induced LTD