All Phenotypes Chrm1<tm1Stl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Chrm1^tm1Stl
targeted mutation 1, Susumu Tonegawa
MGI:2158743

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrm1^tm1Stl/Chrm1^tm1Stl	C57BL/6-Chrm1^tm1Stl	MGI:3785159
hm2	Chrm1^tm1Stl/Chrm1^tm1Stl	involves: C57BL/6	MGI:3785167
ht3	Chrm1^tm1Stl/Chrm1⁺	C57BL/6-Chrm1^tm1Stl	MGI:3785160

Allelic Composition	Chrm1^tm1Stl/Chrm1^tm1Stl
Genetic Background	C57BL/6-Chrm1^tm1Stl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm1^tm1Stl mutation (1 available); any Chrm1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased locomotor activity ( J:73448 )

• mice travel 1.5-fold greater distance in a novel environment than wild-type mice

• however, hyperactivity could be attenuated with administration of haloperidol (a dopamine D2 antagonist)

• mice exhibit a greater increase in locomotor activity (1.5-fold higher when treated with amphetamines or cocaine compared to similarly treated wild-type mice

homeostasis/metabolism

increased dopamine level ( J:73448 )

• striatal extracellular dopamine levels are 2-fold higher than in wild-type mice

• mice exhibit a greater increase in extracellular dopamine levels when treated with amphetamines or cocaine compared to similarly treated wild-type mice

Allelic Composition	Chrm1^tm1Stl/Chrm1^tm1Stl
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm1^tm1Stl mutation (1 available); any Chrm1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal excitatory postsynaptic potential ( J:112782 )

• mice exhibit a greater increase in excitatory postsynaptic potential amplitude following treatment with MCN-A-343, a selective Chrm1 inhibitor, compared to in wild-type mice

• however, responses to GABAB and Chrm1 antagonist are normal

reduced long-term depression ( J:112782 )

• long term depression of field excitatory postsynaptic potential induced by muscarine treatment is reduced compared to in similarly treated wild-type mice

decreased paired-pulse facilitation ( J:112782 )

• when treated with muscarine

Allelic Composition	Chrm1^tm1Stl/Chrm1⁺
Genetic Background	C57BL/6-Chrm1^tm1Stl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrm1^tm1Stl mutation (1 available); any Chrm1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased locomotor activity ( J:73448 )

• mice travel 1.3-fold greater distance in a novel environment than wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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