Phenotypes associated with this allele

• Allele Symbol: Casp1^tm1Flv
• Allele Name: targeted mutation 1, Richard Flavell
• Allele ID: MGI:2158744
• Summary: 10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Casp1^tm1Flv/Casp1^tm1Flv	involves: 129S2/SvPas * C57BL/6N	MGI:6452824
ht2	Casp1^tm1Flv/Casp1^+	involves: 129S2/SvPas * C57BL/6N	MGI:6452825
cx3	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del	B6.129S2-Casp1^tm1Flv	MGI:3711186
cx4	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Slc11a1^s/Slc11a1^s	B6.129S2-Casp1^tm1Flv	MGI:3722759
cx5	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Slc11a1^r/Slc11a1^r	involves: 129S2/SvPas	MGI:3722760
cx6	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del	involves: 129S2/SvPas	MGI:4839914
cx7	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Il1r1^tm1Imx/Il1r1^tm1Imx	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	MGI:2179470
cx8	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del	involves: 129S2/SvPas * C57BL/6	MGI:2179469
cx9	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del	involves: 129S2/SvPas * C57BL/6J	MGI:5467384
cx10	Casp1^tm1Flv/Casp1^tm1Flv St18^tm1c(KOMP)Wtsi/St18^tm1c(KOMP)Wtsi	involves: C57BL/6 * C57BL/6N * DBA/2	MGI:6489911

Genotype
MGI:6452824

hm1

• Allelic Composition: Casp1^tm1Flv/Casp1^tm1Flv
• Genetic Background: involves: 129S2/SvPas * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:293379 )

• normal body weight after inducing persistent hyperglycemia in uninephrectomized mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:293379 )

• no albuminuria after inducing persistent hyperglycemia in uninephrectomized mice

• normal blood glucose level after inducing persistent hyperglycemia in uninephrectomized mice

renal/urinary system

renal/urinary system phenotype ( J:293379 )

N • normal mesangial matrix after inducing persistent hyperglycemia in uninephrectomized mice

Genotype
MGI:6452825

ht2

• Allelic Composition: Casp1^tm1Flv/Casp1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6N

growth/size/body

growth/size/body region phenotype ( J:293379 )

N • normal body weight after inducing persistent hyperglycemia in uninephrectomized mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:293379 )

N • normal blood glucose level after inducing persistent hyperglycemia in uninephrectomized mice

N • no albuminuria after inducing persistent hyperglycemia in uninephrectomized mice

renal/urinary system

renal/urinary system phenotype ( J:293379 )

N • normal mesangial matrix after inducing persistent hyperglycemia in uninephrectomized mice

Genotype
MGI:3711186

cx3

• Allelic Composition: Casp1^tm1Flv/Casp1^tm1Flv; Casp4^del/Casp4^del
• Genetic Background: B6.129S2-Casp1^tm1Flv

renal/urinary system

renal tubular necrosis ( J:97733 )

• reduced compared to controls after LPS induced acute kidney failure but not significantly

decreased renal glomerular filtration rate ( J:97733 )

• reduced after LPS induced acute kidney failure but less than in controls

kidney failure ( J:97733 )

• LPS induced acute kidney failure is also less severe

digestive/alimentary system

abnormal gut flora balance ( J:173245 )

• mice and co-housed wild-type mice exhibit expanded bacterial phylotypes compared with wild-type mice

increased susceptibility to induced colitis ( J:173245 )

• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice

• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice

immune system

increased susceptibility to induced colitis ( J:173245 )

• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice

• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice

decreased interleukin-1 beta secretion ( J:160545 )

• in LPS-primed bone marrow derived macrophages stimulated by S. typhimurium

Genotype
MGI:3722759

cx4

• Allelic Composition: Casp1^tm1Flv/Casp1^tm1Flv; Casp4^del/Casp4^del; Slc11a1^s/Slc11a1^s
• Genetic Background: B6.129S2-Casp1^tm1Flv

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:124378 )

• when infected with 10⁵ Salmonella typhimurium, mice exhibit increased mortality compared to wild-type mice

immune system

cecum inflammation ( J:124378 )

• the ceca of mice infected with Salmonella typhimurium and treated with streptomycin exhibit increased inflammation with more edema, more neutrophil infiltration and epithelial disruption

increased susceptibility to bacterial infection ( J:124378 )

• when infected with 10⁵ Salmonella typhimurium, mice exhibit increased mortality compared to wild-type mice

• when infected with 10⁶ Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased to a greater extent than in either single allele homozygote

• following infection with Salmonella typhimurium, Peyer patches exhibit slightly increased bacterial load compared to in Slc11a1^s homozygotes

digestive/alimentary system

cecum inflammation ( J:124378 )

• the ceca of mice infected with Salmonella typhimurium and treated with streptomycin exhibit increased inflammation with more edema, more neutrophil infiltration and epithelial disruption

Genotype
MGI:3722760

cx5

• Allelic Composition: Casp1^tm1Flv/Casp1^tm1Flv; Casp4^del/Casp4^del; Slc11a1^r/Slc11a1^r
• Genetic Background: involves: 129S2/SvPas

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:124378 )

• when infected with 10⁶ Salmonella typhimurium, mice have a shorter time to death than Slc11a1^r homozygotes

immune system

increased susceptibility to bacterial infection ( J:124378 )

• when infected with 10⁶ Salmonella typhimurium, mice have a shorter time to death than Slc11a1 homozygotes

• when infected with 10⁶ Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased relative to in Slc11a1 homozygotes

• following infection with Salmonella typhimurium, Peyer patches exhibit slightly increased bacterial load compared to in Slc11a1^r homozygotes

Genotype
MGI:4839914

cx6

• Allelic Composition: Casp1^tm1Flv/Casp1^tm1Flv; Casp4^del/Casp4^del
• Genetic Background: involves: 129S2/SvPas

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:59893 )

• only 3 of 16 mice injected with B16M cells die after 12 days compared to all similarly treated wild-type mice

neoplasm

decreased metastatic potential ( J:59893 )

• mice injected with B16 cells exhibit reduced metastasis (by volume and density) in the liver compared with similarly treated wild-type mice

• mice injected with B16 cells exhibit decreased metastasis volume, an indicator of metastatic growth, compared with similarly treated wild-type mice

decreased tumor growth/size ( J:59893 )

• mice injected with B16 cells exhibit decreased metastasis volume, an indicator of metastatic growth, compared with similarly treated wild-type mice

Genotype
MGI:2179470

cx7

• Allelic Composition: Casp1^tm1Flv/Casp1^tm1Flv; Casp4^del/Casp4^del; Il1r1^tm1Imx/Il1r1^tm1Imx
• Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

immune system

decreased susceptibility to endotoxin shock ( J:43088 )

• resistance to endotoxin shock induced by high dose lipopolysaccharide (LPS)

Genotype
MGI:2179469

cx8

• Allelic Composition: Casp1^tm1Flv/Casp1^tm1Flv; Casp4^del/Casp4^del
• Genetic Background: involves: 129S2/SvPas * C57BL/6

immune system

decreased thymocyte apoptosis ( J:24258 )

• Fas mediated apoptosis in thymocytes is suppressed

impaired neutrophil chemotaxis ( J:124226 )

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

decreased circulating interferon-gamma level ( J:115310 )

• serum levels are reduced in mice given Il12 daily

abnormal cytokine secretion ( J:24258 )

decreased interferon-gamma secretion ( J:115310 )

• significantly reduced levels of Ifn gamma are induced by Il12 in splenocytes

decreased interleukin-1 alpha secretion ( J:24258 )

• no Il1 alpha is released by monocytes in response to LPS

decreased interleukin-1 beta secretion ( J:24258 )

• no Il1 beta is released by monocytes in response to LPS

decreased interleukin-18 secretion ( J:115310 )

• significantly lower levels of Il18 are released by cultured splenocytes

• Il12 treatment fails to cause increased Il18 release but liver and spleen levels increase comparable to controls

decreased interleukin-6 secretion ( J:24258 )

• secretion by monocytes in response to LPS is reduced

decreased tumor necrosis factor secretion ( J:24258 )

• secretion by monocytes in response to LPS is reduced

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:57101 )

decreased susceptibility to endotoxin shock ( J:43088 )

• 10 fold increase in survival (from 6% in wild-type to 60%) of mice challenged with a high dose of LPS

increased susceptibility to bacterial infection ( J:117251 )

• macrophages infected with Legionella and cultured for 72 hours show a 200-fold increase in bacterial number

renal/urinary system

renal tubular necrosis ( J:69421 )

• reduced after ischemic reperfusion as compared to controls

kidney failure ( J:69421 )

• ischemic acute renal failure is less severe than in controls

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:115310 )

• serum levels are reduced in mice given Il12 daily

hematopoietic system

decreased thymocyte apoptosis ( J:24258 )

• Fas mediated apoptosis in thymocytes is suppressed

impaired neutrophil chemotaxis ( J:124226 )

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

cellular

decreased thymocyte apoptosis ( J:24258 )

• Fas mediated apoptosis in thymocytes is suppressed

impaired neutrophil chemotaxis ( J:124226 )

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:24258 )

• Fas mediated apoptosis in thymocytes is suppressed

Genotype
MGI:5467384

cx9

• Allelic Composition: Casp1^tm1Flv/Casp1^tm1Flv; Casp4^del/Casp4^del
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

neoplasm

decreased incidence of tumors by chemical induction ( J:191239 )

• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit later onset and a lower incidence of tumors compared with type mice

integument

integument phenotype ( J:191239 )

N • untreated or TPA, TNF or EGF-treated keratinocytes exhibit normal proliferation

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:191239 )

• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit later onset and a lower incidence of tumors compared with type mice

Genotype
MGI:6489911

cx10

• Allelic Composition: Casp1^tm1Flv/Casp1^tm1Flv; St18^{tm1c(KOMP)Wtsi}/St18^{tm1c(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N * DBA/2

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:298828 )

• reduced survival rates after LPS injection