Analysis Tools
mortality/aging
|
• although present in Mendelian ratios at E10.5, mice die by E11.5
|
embryo
|
• at E9.5, mice exhibit massive spillage of embryonic red cells into the yolk sac cavity due to loss of vascular integrity unlike in wild-type mice
• at E10.5, yolk sac vascular is empty unlike in wild-type mice
|
|
• at E9.5, variable degrees of necrosis are observed unlike in wild-type mice
• at E10.5, necrosis is severe in all mice unlike in wild-type mice
|
pale yolk sac
(
J:33831
)
|
• at E10.5
|
cardiovascular system
|
• at E9.5, mice exhibit massive spillage of embryonic red cells into the yolk sac cavity due to loss of vascular integrity unlike in wild-type mice
• at E10.5, yolk sac vascular is empty unlike in wild-type mice
|
|
• the heart is distended
|
hemorrhage
(
J:33831
)
|
• at E9.5, mice exhibit hemorrhage in extraembryonic and embryonic tissues unlike wild-type mice
• at E10.5, mice exhibit macroscopic nucleated embryonic red cells in the yolk sac cavities
|
|
• at E9.5, mice exhibit loss of vascular integrity in the pericardial sac despite grossly normal vascular morphology
|
nervous system
|
• at E9.5, 13 of 16 mice exhibit poorly developed forebrain structures and aplasia unlike wild-type mice
|
growth/size/body
|
• the heart is distended
|
hematopoietic system
|
• at E9.5, mice have very few embryonic (nucleated) red cells within the yolk sac, embryonic, and placental vasculatures unlike wild-type mice
|
integument
