Analysis Tools
mortality/aging
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• LPS-treated mice exhibit increased mortality compared with similarly treated wild-type mice
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homeostasis/metabolism
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• plasma D-dimer levels are increased compared to in wild-type mice
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• LPS-treated mice exhibit increased IL1beta serum levels compared with similarly treated wild-type mice
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• LPS-treated mice exhibit increased IL6 serum levels compared with similarly treated wild-type mice
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• LPS-treated mice exhibit a 2-fold reduction in serum TNFalpha levels compared with similarly treated wild-type mice
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• plasma thrombin-antithrombin (TAT), D-dimer, fibrinopeptide A (FPA), and plasmin-antiplasmin (PAP) are increased compared to in wild-type mice
• however, mice control bleeding normally after an initial period of increased blood loss
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• after FeCl3-induced injury mice exhibit accelerated arterial thrombus growth compared with wild-type mice
• following ligation near the carotid bifurcation, mice exhibit more extensive thrombotic lesions with increased neointimal mass over the entire length of the artery, halfway towards the aortic arch, or over the distal third of the ligated vessel compared with similarly treated wild-type mice that develop thrombic lesions within 1 mm of the ligation site
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immune system
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• LPS-induced fibrin deposits are more pronounced than in similarly treated wild-type mice
• however, no abnormal fibrin deposits are observed in un-induced mice
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• LPS-treated mice exhibit increased IL1beta serum levels compared with similarly treated wild-type mice
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• LPS-treated mice exhibit increased IL6 serum levels compared with similarly treated wild-type mice
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• LPS-treated mice exhibit a 2-fold reduction in serum TNFalpha levels compared with similarly treated wild-type mice
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• LPS-treated mice exhibit increased mortality, elevated IL6 and IL1beta serum levels, decreased TNFalpha serum levels, and increased fibrin deposits in the kidney, heart, spleen, and lung compared with similarly treated wild-type mice
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hematopoietic system
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• LPS-induced fibrin deposits are more pronounced than in similarly treated wild-type mice
• however, no abnormal fibrin deposits are observed in un-induced mice
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cardiovascular system
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• LPS-induced fibrin deposits are more pronounced than in similarly treated wild-type mice
• however, no abnormal fibrin deposits are observed in un-induced mice
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renal/urinary system
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• LPS-induced fibrin deposits are more pronounced than in similarly treated wild-type mice
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respiratory system
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• LPS-induced fibrin deposits are more pronounced than in similarly treated wild-type mice
• however, no abnormal fibrin deposits are observed in un-induced mice
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