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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Man2a2tm1Mfu
targeted mutation 1, Michiko N Fukuda
MGI:2158829
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Man2a2tm1Mfu/Man2a2tm1Mfu involves: 129S1/Sv * 129X1/SvJ MGI:2663843
cx2
 		Man2a1tm1Jxm/Man2a1tm1Jxm
Man2a2tm1Mfu/Man2a2tm1Mfu 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3850629


Genotype
MGI:2663843
hm1
Allelic
Composition		 Man2a2tm1Mfu/Man2a2tm1Mfu
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Man2a2tm1Mfu mutation (0 available); any Man2a2 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
small testis ( J:73658 , J:80105 )
(J:73658)
(J:80105)
abnormal spermatogenesis ( J:73658 , J:80105 )
• premature release of immature spermatocytes from Sertoli cells and into the epididymis (J:73658)
• in vitro analysis showed the failed adhesion to be due to a defect in the germ cells, not in the Sertoli cells (J:73658)
(J:80105)
oligozoospermia ( J:73658 , J:80105 )
• reduced number of spermatozoa in the caudal epididymis (J:73658)
(J:80105)
male infertility ( J:73658 , J:80105 )
• males were largely infertile, though some impregnated wild-type females after a 3 month mating period, resulting in litters of 1 to 3 pups (J:73658)
(J:80105)

endocrine/exocrine glands
small testis ( J:73658 , J:80105 )
(J:73658)
(J:80105)

cellular
oligozoospermia ( J:73658 , J:80105 )
• reduced number of spermatozoa in the caudal epididymis (J:73658)
(J:80105)




Genotype
MGI:3850629
cx2
Allelic
Composition		 Man2a1tm1Jxm/Man2a1tm1Jxm
Man2a2tm1Mfu/Man2a2tm1Mfu
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Man2a1tm1Jxm mutation (1 available); any Man2a1 mutation (62 available)
Man2a2tm1Mfu mutation (0 available); any Man2a2 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:111055 )
• most die shortly after birth
postnatal lethality, incomplete penetrance ( J:111055 )
• very few survive to 3 weeks

respiratory system
abnormal pulmonary alveolus morphology ( J:111055 )
• reduced alveolar air space
abnormal pulmonary alveolus epithelial cell morphology ( J:111055 )
• thicker pulmonary epithelium layer
abnormal breathing pattern ( J:111055 )
• newborns actively gasp for air
• fail to breath properly

liver/biliary system
abnormal liver morphology ( J:111055 )
• frequently show liver damage
• E15 liver cells with abnormal vacuoles and enlarged mitochondria

renal/urinary system
abnormal proximal convoluted tubule morphology ( J:111055 )
• E15 cells with abnormal vacuoles and enlarged mitochondria




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory