Phenotypes associated with this allele

• Allele Symbol: Oprm1^tm1Kff
• Allele Name: targeted mutation 1, Brigitte L Kieffer
• Allele ID: MGI:2159000
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprm1^tm1Kff/Oprm1^tm1Kff	involves: 129S2/SvPas	MGI:3054841
hm2	Oprm1^tm1Kff/Oprm1^tm1Kff	involves: 129S2/SvPas * C57BL/6J	MGI:5538574
cx3	Oprm1^tm1Kff/Oprm1^+ Tg(MECP2)1Hzo/0	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:5314413

Genotype
MGI:3054841

hm1

• Allelic Composition: Oprm1^tm1Kff/Oprm1^tm1Kff
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to morphine ( J:36241 , J:52952 , J:207536 )

• no effect on conditioned place preference induced by morphine (J:36241)

• prolonged morphine administration does not create symptoms of dependence or withdrawal (J:36241)

• in a tail flick assay, mice treated with morphine-6beta-glucuronide (M6G) or 6-acetyl-morphine exhibit no analgesic response unlike similarly treated wild-type mice (J:52952)

• morphine-induced analgesia is abolished (J:207536)

• however, loperamine-induced analgesia is maintained (J:207536)

decreased behavioral withdrawal response ( J:62551 )

• prolonged morphine administration does not create symptoms of dependence or withdrawal

impaired behavioral response to anesthetic ( J:52952 )

• in a tail flick assay, mice treated with morphine-6beta-glucuronide (M6G) or 6-acetyl-morphine exhibit no analgesic response unlike similarly treated wild-type mice

increased coping response ( J:62551 )

• slightly decreased immobility time in forced-swim test

decreased locomotor activity ( J:36241 )

• mild change

abnormal pain threshold ( J:36241 , J:62551 )

• administration of morphine does not affect threshold response in tail immersion and hot plate tests (J:36241)

• attenuated response after foot-shock exposure (J:62551)

Genotype
MGI:5538574

hm2

• Allelic Composition: Oprm1^tm1Kff/Oprm1^tm1Kff
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

behavior/neurological

abnormal social investigation ( J:204731 )

♂ • males do not show a change in social exploratory activity when exposed to playback of female ultrasonic vocalizations unlike wild-type males that exhibit an increase of exploratory activity

♂ • males however, exhibit normal behavior in the auditory cued-fear conditioning task

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:204731

Genotype
MGI:5314413

cx3

• Allelic Composition: Oprm1^tm1Kff/Oprm1⁺; Tg(MECP2)1Hzo/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB/N

behavior/neurological

increased anxiety-related response ( J:181213 )

• double mutants exhibit a similar level of anxiety-like behavior in the elevated plus maze and light/dark box as single Tg(MECP2)1Hzo hemizygous mice

• however, double mutants exhibit improved social behavior deficits compared to single Tg(MECP2)1Hzo mice, spending more time investigating both familiar and novel partners