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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Oprm1tm1Uhl
targeted mutation 1, George R Uhl
MGI:2159001
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Oprm1tm1Uhl/Oprm1tm1Uhl involves: 129S7/SvEvBrd * C57BL/6J MGI:3623032
ht2
Oprm1tm1Uhl/Oprm1+ either: B6.129S7-Oprm1tm1Uhl or (involves: 129S7/SvEvBrd) MGI:3623099


Genotype
MGI:3623032
hm1
Allelic
Composition
Oprm1tm1Uhl/Oprm1tm1Uhl
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1tm1Uhl mutation (1 available); any Oprm1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at 750 mg/kg morphine, 25% of homozygotes lived while all wild-type littermates died

behavior/neurological
• null mice unlike wild-type show no preference for environments paired with 10 mg/kg morphine
• nulls displayed lower lever-pressing behavior at a dose of 1 mg/kg/injection of morphine than heterozygotes or wild-type
• in naloxone-precipitated withdrawal after 5 days of chronic morphine administration, homozygotes show no withdrawal-related jumping but heterozygotes and wild-type did after pretreatment for 3 days
• null mice show no increase in locomotor activity in response to morphine
• in homozygotes, administration of morphine does not induce analgesia (no increase in latency to respond) in tail flick or hot plate tests
• in homozygotes, administration of morphine does not induce analgesia (no increase in latency to respond) in tail flick or hot plate tests
• homozygotes display shorter latencies in the tail flick test compared to wild-type at water temperatures of 50 and 53 degrees
• at 55 degrees, there is a decrease in time to first paw lick in mutants

homeostasis/metabolism
• at 750 mg/kg morphine, 25% of homozygotes lived while all wild-type littermates died




Genotype
MGI:3623099
ht2
Allelic
Composition
Oprm1tm1Uhl/Oprm1+
Genetic
Background
either: B6.129S7-Oprm1tm1Uhl or (involves: 129S7/SvEvBrd)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1tm1Uhl mutation (1 available); any Oprm1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at 650 mg/kg morphine, heterozygotes show longer latencies before morphine is lethal than do wild-type

behavior/neurological
• heterozygous mice on the mixed background show almost double the preference for compartments paired with 5 or 10 mg/kg morphine compared to wild-type

homeostasis/metabolism
• at 650 mg/kg morphine, heterozygotes show longer latencies before morphine is lethal than do wild-type
• at 650 mg/kg morphine, heterozygotes show longer latencies before morphine is lethal than do wild-type





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory