Phenotypes associated with this allele

• Allele Symbol: Oprm1^tm1Lyu
• Allele Name: targeted mutation 1, Lei Yu
• Allele ID: MGI:2159002
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprm1^tm1Lyu/Oprm1^tm1Lyu	involves: Black Swiss	MGI:3845908
ht2	Oprm1^tm1Lyu/Oprm1^+	involves: Black Swiss	MGI:3845909

Genotype
MGI:3845908

hm1

• Allelic Composition: Oprm1^tm1Lyu/Oprm1^tm1Lyu
• Genetic Background: involves: Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:39864 )

♂

asthenozoospermia ( J:39864 )

♂

decreased litter size ( J:39864 )

• males sire smaller litters

reduced male fertility ( J:39864 )

♂ • sire smaller litters and the time needed to produce a pregnancy is longer

behavior/neurological

impaired behavioral response to morphine ( J:39864 )

• morphine fails to induce increased horizontal activity levels or reduced vertical activity levels

increased vertical activity ( J:39864 )

• morphine fails to induced reduced vertical activity levels unlike in wild-type mice

• however, untreated vertical activity levels are similar to wild-type controls

decreased locomotor activity ( J:39864 )

• reduced spontaneous locomotor activity

• morphine fails to induced increased horizontal activity levels

decreased chemically-elicited antinociception ( J:39864 )

• fail to show a morphine induced increase in tail flick latency

abnormal copulatory plug deposition ( J:39864 )

♂ • in a 2 hr test males fail to produce seminal plugs however, males can produce seminal plugs when left overnight with a female

decreased copulatory plug deposition ( J:39864 )

♂ • the percentage of overnight seminal plugs is significantly reduced compared with that of wild-type males

abnormal intromission ( J:39864 )

♂ • the number of intromissions during each test session is significantly reduced

decreased mounting behavior ( J:39864 )

♂ • latency to mounting is significantly increased while the number of appropriate mounts is significantly decreased

♂ • however, total contact time with the female (cumulative time when the male is investigating the female mouse, including mounting and sniffing of body and genital areas) is not reduced

hematopoietic system

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen

abnormal common myeloid progenitor cell morphology ( J:39864 )

• increase in the number of granulocyte-macrophage (CFU-GM) and multipotential (CFU-GEMM) progenitors in the femoral bone marrow

increased erythroid progenitor cell number ( J:39864 )

• increase in the number of erythroid progenitors in the femoral bone marrow

abnormal bone marrow cell physiology ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the femoral bone marrow

immune system

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen

cellular

oligozoospermia ( J:39864 )

♂

asthenozoospermia ( J:39864 )

♂

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen

Genotype
MGI:3845909

ht2

• Allelic Composition: Oprm1^tm1Lyu/Oprm1⁺
• Genetic Background: involves: Black Swiss

behavior/neurological

impaired behavioral response to morphine ( J:39864 )

• morphine fails to induce increased horizontal activity levels or reduced vertical activity levels

increased vertical activity ( J:39864 )

• morphine fails to induced reduced vertical activity levels unlike in wild-type mice

• however, untreated vertical activity levels are similar to wild-type controls

decreased locomotor activity ( J:39864 )

• reduced spontaneous locomotor activity compared to wild-type controls but activity levels are higher than in homozygous null mice

• morphine fails to induced increased activity levels

abnormal copulatory plug deposition ( J:39864 )

♂ • in a 2 hr test males fail to produce seminal plugs however, males can produce seminal plugs when left overnight with a female

hematopoietic system

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen

abnormal bone marrow cell physiology ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the femoral bone marrow

immune system

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen

cellular

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen