Phenotypes associated with this allele

• Allele Symbol: Nos3^tm1Gdk
• Allele Name: targeted mutation 1, Axel Godecke
• Allele ID: MGI:2159003
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nos3^tm1Gdk/Nos3^tm1Gdk	B6.129P2-Nos3^tm1Gdk	MGI:3618747
hm2	Nos3^tm1Gdk/Nos3^tm1Gdk	involves: 129P2/OlaHsd * C57BL/6	MGI:3618724

Genotype
MGI:3618747

hm1

• Allelic Composition: Nos3^tm1Gdk/Nos3^tm1Gdk
• Genetic Background: B6.129P2-Nos3^tm1Gdk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:64214 )

enhanced long-term object recognition memory ( J:64214 )

• exhibit improved performance during long-term retention and reversal learning

abnormal spatial learning ( J:64214 )

• exhibit improved performance on a water maze, finding the platform faster than controls

increased anxiety-related response ( J:64214 )

• in the elevated plus-maze test, spend less time on the open and more time on the walled arms of the apparatus, indicating an increase in anxiety-related behavior

• in the open field test, spend more time in the corners than the center, indicating an increase in anxiety-related avoidance of open space

decreased locomotor activity ( J:64214 )

• in the open field test, are less active than wild-type but show unimpaired habituation

homeostasis/metabolism

abnormal dopamine level ( J:64214 )

• dopamine is increased in the cerebellum of water maze-trained mutants and the turnover rates for dopamine are decreased in the cerebellum but are increased in the ventral striatum compared to wild-type

abnormal serotonin level ( J:64214 )

• 5-HIAA is increased in the cerebellum of water maze-trained mutants compared to wild-type and the turnover rates for serotonin are increased in the frontal cortex and ventral straitum

Genotype
MGI:3618724

hm2

• Allelic Composition: Nos3^tm1Gdk/Nos3^tm1Gdk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

cardiovascular system

decreased heart rate ( J:46061 )

hypertension ( J:46061 )

• mean arterial blood pressure measured under urethane anesthesia is increased by 28 mm Hg, however do not observe cardiac hypertrophy

increased vasoconstriction ( J:46061 )

• intracoronary infusion of acetylcholine results in even more pronounced vasoconstriction than seen in wild-type, resulting in a flow decrease by 71%, however vasodilation was unaffected

muscle

increased vasoconstriction ( J:46061 )

• intracoronary infusion of acetylcholine results in even more pronounced vasoconstriction than seen in wild-type, resulting in a flow decrease by 71%, however vasodilation was unaffected

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
essential hypertension		DOID:10825	OMIM:145500 OMIM:603918 OMIM:604329 OMIM:607329 OMIM:608742 OMIM:610261 OMIM:610262 OMIM:610948 OMIM:611014	J:46061