Phenotypes associated with this allele

• Allele Symbol: Neurod6^tm1Kan
• Allele Name: targeted mutation 1, Klaus-Armin Nave
• Allele ID: MGI:2159008
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neurod6^tm1Kan/Neurod6^tm1Kan	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3850033
cx2	Neurod1^tm1Mjts/Neurod1^tm1Mjts Neurod6^tm1Kan/Neurod6^tm1Kan	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J	MGI:3850034

Genotype
MGI:3850033

hm1

• Allelic Composition: Neurod6^tm1Kan/Neurod6^tm1Kan
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:45777 )

N • no obvious behavioral abnormalities

Genotype
MGI:3850034

cx2

• Allelic Composition: Neurod1^tm1Mjts/Neurod1^tm1Mjts; Neurod6^tm1Kan/Neurod6^tm1Kan
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J

mortality/aging

postnatal lethality, complete penetrance ( J:62118 )

• born at the expected ratio but rarely survive to the age of two days

growth/size/body

postnatal growth retardation ( J:62118 )

• overall growth is reduced

nervous system

abnormal nervous system morphology ( J:62118 )

decreased brain size ( J:62118 )

absent dentate gyrus ( J:62118 )

abnormal hippocampus granule cell layer ( J:62118 )

• absence of demarcated granule cell layer

• ectopic aggregation of cells in the hilar region that fail to migrate to the dentate gyrus

• ectopic cells arrest during terminal differentiation

abnormal nervous system physiology ( J:62118 )

impaired ability to fire action potentials ( J:62118 )

• increased number of cells that can fire only single non regenerative action potentials

abnormal neuron physiology ( J:62118 )

• increased number of cells that can fire only single non regenerative action potentials

• ectopic granule cells have small Na+ currents