All Phenotypes Neurog2<tm1Fgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Neurog2^tm1Fgu
targeted mutation 1, Francois Guillemot
MGI:2159009

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neurog2^tm1Fgu/Neurog2^tm1Fgu	involves: 129S1/Sv * 129X1/SvJ	MGI:3639857
cx2	Ascl1^tm1And/Ascl1^tm1And Neurog2^tm1Fgu/Neurog2^tm1Fgu	involves: 129 * 129S1/Sv * 129X1/SvJ	MGI:4420907
cx3	Neurod1^tm1Jle/Neurod1^tm1Jle Neurog2^tm1Fgu/Neurog2^tm1Fgu	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ	MGI:4420922
cx4	Ascl1^tm1And/Ascl1^tm1And Neurog2^tm1Fgu/Neurog2^tm1Fgu	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * ICR	MGI:4420918
cx5	Neurod4^tm1Kag/Neurod4^tm1Kag Neurog2^tm1Fgu/Neurog2^tm1Fgu	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR	MGI:4420921
cx6	Ascl1^tm1And/Ascl1^tm1And Neurod4^tm1Kag/Neurod4^tm1Kag Neurog2^tm1Fgu/Neurog2^tm1Fgu	involves: 129/Sv * C57BL/6 * CBA * ICR	MGI:4420915
cx7	Neurod1^tm1Jle/Neurod1^tm1Jle Neurod4^tm1Kag/Neurod4^tm1Kag Neurog2^tm1Fgu/Neurog2^tm1Fgu	involves: 129/Sv * C57BL/6 * CBA * ICR	MGI:4420913

Allelic Composition	Neurog2^tm1Fgu/Neurog2^tm1Fgu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog2^tm1Fgu mutation (0 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:46667 )

• mutants surviving past the first day die between 4 and 25 days of age

neonatal lethality, incomplete penetrance ( J:46667 )

• most mutants die during the first postnatal day

growth/size/body

decreased body size ( J:46667 )

• homozygotes are smaller in size than littermates

postnatal growth retardation ( J:46667 )

• mutants surviving past the first day exhibit progressive growth retardation until time of death

behavior/neurological

abnormal suckling behavior ( J:46667 )

• mutants are unable to feed normally, as their stomachs lacked milk and were filled with air

abnormal limb posture ( J:46667 )

• mutants exhibit abnormal limb posturing

decreased locomotor activity ( J:46667 )

• mutants exhibit a low level of activity after birth

• surviving mutants exhibit decreased motor activity with time until death between 4 and 25 days of age

nervous system

abnormal autonomic nervous system morphology ( J:157532 )

abnormal parasympathetic ganglion morphology ( J:157532 )

• at 13.5 all parasympathetic ganglia of the head are missing

abnormal motor neuron morphology ( J:157532 )

• visceromotor neurons project abnormally in the facial nerve

abnormal dorsal interneuron morphology ( J:98830 )

• in E10.5 embryos a subtle increase in the number of dI3 and dI5 neurons is seen

• but, no significant changes in the number of dI2 and dI4/6 neurons is detected

abnormal somatic nervous system morphology ( J:157532 )

abnormal geniculate ganglion morphology ( J:46667 )

• neuronal differentiation is absent or abnormal in this ganglion

abnormal petrosal ganglion morphology ( J:46667 )

• neuronal differentiation is absent or abnormal in this ganglion

abnormal facial nerve morphology ( J:157532 )

• neither the corda tympani nor the greater superficial petrosal nerve have formed at E11.5

abnormal dorsal root ganglion morphology ( J:74525 )

• mice show a transient defect in neurogenesis in populations of sensory neurons in the DRGs

Allelic Composition	Ascl1^tm1And/Ascl1^tm1And Neurog2^tm1Fgu/Neurog2^tm1Fgu
Genetic Background	involves: 129 * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl1^tm1And mutation (1 available); any Ascl1 mutation (28 available)
Neurog2^tm1Fgu mutation (0 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dorsal interneuron morphology ( J:98830 )

abnormal dorsal interneuron 2 morphology ( J:98830 )

• in E10.5 embryos a dramatic increase in dI2 interneuron number is seen

abnormal dorsal interneuron 3 morphology ( J:98830 )

• at E10.5 embryos show 70% loss of dI3

abnormal dorsal interneuron 4 morphology ( J:98830 )

• at E10.5 embryos show apparent loss of dI4 neurons

abnormal dorsal interneuron 5 morphology ( J:98830 )

• at E10.5 embryos show complete loss of dI5 neurons

Allelic Composition	Neurod1^tm1Jle/Neurod1^tm1Jle Neurog2^tm1Fgu/Neurog2^tm1Fgu
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod1^tm1Jle mutation (1 available); any Neurod1 mutation (29 available)
Neurog2^tm1Fgu mutation (0 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:121047 )

vision/eye

vision/eye phenotype ( J:121047 )

N	• normal number of horizontal cells

decreased retina photoreceptor cell number ( J:121047 )

• decrease is not greater than that in Neurod1^tm1Jle single homozygotes

nervous system

decreased retina photoreceptor cell number ( J:121047 )

• decrease is not greater than that in Neurod1^tm1Jle single homozygotes

Allelic Composition	Ascl1^tm1And/Ascl1^tm1And Neurog2^tm1Fgu/Neurog2^tm1Fgu
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * ICR

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:121047 )

vision/eye

vision/eye phenotype ( J:121047 )

N	• normal number of horizontal cells

Allelic Composition	Neurod4^tm1Kag/Neurod4^tm1Kag Neurog2^tm1Fgu/Neurog2^tm1Fgu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod4^tm1Kag mutation (1 available); any Neurod4 mutation (24 available)
Neurog2^tm1Fgu mutation (0 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:121047 )

nervous system

decreased retina photoreceptor cell number ( J:121047 )

• normal number of horizontal cells

vision/eye

decreased retina photoreceptor cell number ( J:121047 )

• normal number of horizontal cells

Allelic Composition	Ascl1^tm1And/Ascl1^tm1And Neurod4^tm1Kag/Neurod4^tm1Kag Neurog2^tm1Fgu/Neurog2^tm1Fgu
Genetic Background	involves: 129/Sv * C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ascl1^tm1And mutation (1 available); any Ascl1 mutation (28 available)
Neurod4^tm1Kag mutation (1 available); any Neurod4 mutation (24 available)
Neurog2^tm1Fgu mutation (0 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:121047 )

• most die around birth

nervous system

abnormal Muller cell morphology ( J:121047 )

• increase in the number of Muller cells in the inner nuclear layer

decreased amacrine cell number ( J:121047 )

• in the inner nuclear layer

increased retina ganglion cell number ( J:121047 )

abnormal retina bipolar cell morphology ( J:121047 )

• fewer bipolar cells in the inner nuclear layer

abnormal retina horizontal cell morphology ( J:121047 )

• fewer horizontal cells in the inner nuclear layer

vision/eye

abnormal Muller cell morphology ( J:121047 )

• increase in the number of Muller cells in the inner nuclear layer

decreased amacrine cell number ( J:121047 )

• in the inner nuclear layer

abnormal retina bipolar cell morphology ( J:121047 )

• fewer bipolar cells in the inner nuclear layer

abnormal retina horizontal cell morphology ( J:121047 )

• fewer horizontal cells in the inner nuclear layer

abnormal retina layer morphology ( J:121047 )

increased retina ganglion cell number ( J:121047 )

abnormal retina inner nuclear layer morphology ( J:121047 )

• fewer amacrine, horizontal and bipolar cells

• increase in Muller glial cells

Allelic Composition	Neurod1^tm1Jle/Neurod1^tm1Jle Neurod4^tm1Kag/Neurod4^tm1Kag Neurog2^tm1Fgu/Neurog2^tm1Fgu
Genetic Background	involves: 129/Sv * C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurod1^tm1Jle mutation (1 available); any Neurod1 mutation (29 available)
Neurod4^tm1Kag mutation (1 available); any Neurod4 mutation (24 available)
Neurog2^tm1Fgu mutation (0 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:121047 )

• most die around birth

nervous system

abnormal Muller cell morphology ( J:121047 )

• increase in the number cells and the cell bodies are scattered throughout the outer layer indicating an impairment in cell migration

decreased amacrine cell number ( J:121047 )

decreased retina ganglion cell number ( J:121047 )

decreased retina photoreceptor cell number ( J:121047 )

decreased retina cone cell number ( J:121047 )

abnormal retina bipolar cell morphology ( J:121047 )

• virtually no bipolar cells

abnormal retina horizontal cell morphology ( J:121047 )

• virtually no horizontal cells

vision/eye

increased retina apoptosis ( J:121047 )

• TUNEL+ cells are increased in the photoreceptor layer after more than 4 days in culture

abnormal Muller cell morphology ( J:121047 )

• increase in the number cells and the cell bodies are scattered throughout the outer layer indicating an impairment in cell migration

decreased amacrine cell number ( J:121047 )

abnormal retina bipolar cell morphology ( J:121047 )

• virtually no bipolar cells

abnormal retina horizontal cell morphology ( J:121047 )

• virtually no horizontal cells

abnormal retina layer morphology ( J:121047 )

• at E17.5, the retina consists of only 2 cellular layers rather than the normal 3 layers

abnormal retina neuronal layer morphology ( J:121047 )

• fusion of the inner nuclear layer and outer nuclear layer

decreased retina ganglion cell number ( J:121047 )

abnormal retina inner nuclear layer morphology ( J:121047 )

thin retina inner nuclear layer ( J:121047 )

abnormal retina outer nuclear layer morphology ( J:121047 )

• most cells are rods with some amacrine and Mueller cells also present

• Muller glial cell bodies are scattered throughout the outer layer indicating an impairment in cell migration

disorganized retina outer nuclear layer ( J:121047 )

• the inner boundary of the photoreceptor layer is irregular, indicating that the arrangement of photoreceptors is disorganized the inner boundary of the photoreceptor layer is irregular, indicating that the arrangement of photoreceptors is disorganized

abnormal retina photoreceptor layer morphology ( J:121047 )

• the inner boundary of the photoreceptor layer is irregular, indicating that the arrangement of photoreceptors is disorganized

decreased retina photoreceptor cell number ( J:121047 )

decreased retina cone cell number ( J:121047 )

cellular

increased retina apoptosis ( J:121047 )

• TUNEL+ cells are increased in the photoreceptor layer after more than 4 days in culture

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