All Phenotypes Neurog2<tm3(Ascl1)Fgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Neurog2^{tm3(Ascl1)Fgu}
targeted mutation 3, Francois Guillemot
MGI:2159011

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neurog2^{tm3(Ascl1)Fgu}/Neurog2^{tm3(Ascl1)Fgu}	involves: 129S1/Sv * 129X1/SvJ	MGI:4420912
ht2	Neurog2^{tm3(Ascl1)Fgu}/Neurog2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:4420910
ht3	Neurog2^{tm3(Ascl1)Fgu}/Neurog2⁺	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3622998
cx4	Neurog1^tm1And/Neurog1^tm1And Neurog2^{tm3(Ascl1)Fgu}/Neurog2^{tm3(Ascl1)Fgu}	involves: 129S1/Sv * 129X1/SvJ	MGI:3639866

Allelic Composition	Neurog2^{tm3(Ascl1)Fgu}/Neurog2^{tm3(Ascl1)Fgu}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog2^{tm3(Ascl1)Fgu} mutation (1 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dorsal interneuron 2 morphology ( J:98830 )

• in E11.5 embryos decrease in the number of dI2 neurons

abnormal dorsal interneuron 3 morphology ( J:98830 )

• in E11.5 embryos the number of dI3 neurons is elevated

abnormal dorsal interneuron 5 morphology ( J:98830 )

• in E11.5 embryos the number of dI5 neurons is elevated

Allelic Composition	Neurog2^{tm3(Ascl1)Fgu}/Neurog2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog2^{tm3(Ascl1)Fgu} mutation (1 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dorsal interneuron 3 morphology ( J:98830 )

• in E11.5 embryos, increase in dI3 numbers

abnormal dorsal interneuron 5 morphology ( J:98830 )

• in E11.5 embryos, increase in dI5 numbers

Allelic Composition	Neurog2^{tm3(Ascl1)Fgu}/Neurog2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog2^{tm3(Ascl1)Fgu} mutation (1 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal telencephalon development ( J:59428 )

• there is a reduced number of ectopic ventral-type neurons with a lateral rather than dorsal location compared to Neurog2 nulls

• at E12.5, there is an increase in the number of cells expressing a panneuronal marker compared to wild-type

Allelic Composition	Neurog1^tm1And/Neurog1^tm1And Neurog2^{tm3(Ascl1)Fgu}/Neurog2^{tm3(Ascl1)Fgu}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog1^tm1And mutation (1 available); any Neurog1 mutation (19 available)
Neurog2^{tm3(Ascl1)Fgu} mutation (1 available); any Neurog2 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dorsal root ganglion morphology ( J:74525 )

• no differentiation of DRG neurons is seen in double mutants

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