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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Anxa6tm1Moss
targeted mutation 1, Stephen E Moss
MGI:2159012
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Anxa6tm1Moss/Anxa6tm1Moss involves: 129P2/OlaHsd * C57BL/6 MGI:2677158
cx2
 		Anxa5tm1Epo/Anxa5tm1Epo
Anxa6tm1Moss/Anxa6tm1Moss
Col10a1tm1Ksec/Col10a1tm1Ksec 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:5696128
cx3
 		Anxa5tm1Epo/Anxa5tm1Epo
Anxa6tm1Moss/Anxa6tm1Moss 		involves: 129P2/OlaHsd * C57BL/6 MGI:5696127


Genotype
MGI:2677158
hm1
Allelic
Composition		 Anxa6tm1Moss/Anxa6tm1Moss
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa6tm1Moss mutation (2 available); any Anxa6 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:58609 )
N
• homozygotes exhibit no significant differences in fertility, lifespan, heart rate, blood pressure, or cardiovascular response to septic shock relative to wild-type mice
increased heart ventricle muscle contractility ( J:75832 )
• isolated ventricular myocytes show amplified contractile properties (higher rates of shortening and relengthening), as well as accelerated diastolic clearance of Ca2+ from the cytoplasm, indicating altered excitation-contraction coupling (J:75832)

muscle
increased heart ventricle muscle contractility ( J:75832 )
• isolated ventricular myocytes show amplified contractile properties (higher rates of shortening and relengthening), as well as accelerated diastolic clearance of Ca2+ from the cytoplasm, indicating altered excitation-contraction coupling (J:75832)

immune system
immune system phenotype ( J:58609 )
N
• homozygotes exhibit no significant differences in thymic, splenic, or bone marrow lymphocyte levels relative to wild-type mice




Genotype
MGI:5696128
cx2
Allelic
Composition		 Anxa5tm1Epo/Anxa5tm1Epo
Anxa6tm1Moss/Anxa6tm1Moss
Col10a1tm1Ksec/Col10a1tm1Ksec
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa5tm1Epo mutation (0 available); any Anxa5 mutation (24 available)
Anxa6tm1Moss mutation (2 available); any Anxa6 mutation (42 available)
Col10a1tm1Ksec mutation (0 available); any Col10a1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased dendritic cell number ( J:193886 )
• decreased CD11c+ dendritic cells at 1 year in female mice
increased B cell number ( J:193886 )
• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
increased T-helper cell number ( J:193886 )
• CD4+/CD8- T-helper cells at 1 year in the spleen

skeleton
abnormal femur morphology ( J:193886 )
• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice
increased width of hypertrophic chondrocyte zone ( J:193886 )
• with increased cell numbers

limbs/digits/tail
abnormal femur morphology ( J:193886 )
• at 1 month and 1 year, female mice exhibit decreased periosteal and endosteal circumference of the femora compared with wild-type mice

hematopoietic system
decreased dendritic cell number ( J:193886 )
• decreased CD11c+ dendritic cells at 1 year in female mice
increased B cell number ( J:193886 )
• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age
increased T-helper cell number ( J:193886 )
• CD4+/CD8- T-helper cells at 1 year in the spleen




Genotype
MGI:5696127
cx3
Allelic
Composition		 Anxa5tm1Epo/Anxa5tm1Epo
Anxa6tm1Moss/Anxa6tm1Moss
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Anxa5tm1Epo mutation (0 available); any Anxa5 mutation (24 available)
Anxa6tm1Moss mutation (2 available); any Anxa6 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased dendritic cell number ( J:193886 )
• decreased CD11c+ dendritic cells at 1 year in female mice
increased B cell number ( J:193886 )
• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age

hematopoietic system
decreased dendritic cell number ( J:193886 )
• decreased CD11c+ dendritic cells at 1 year in female mice
increased B cell number ( J:193886 )
• increased percent of CD19+ B cells in the bone marrow at 1 year of age
• increased IgM+/IgD+ naive B cells at 1 year of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory