All Phenotypes Atoh7<tm1Gan> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atoh7^tm1Gan
targeted mutation 1, Lin Gan
MGI:2159013

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atoh7^tm1Gan/Atoh7^tm1Gan	B6.Cg-Atoh7^tm1Gan	MGI:3842517
hm2	Atoh7^tm1Gan/Atoh7^tm1Gan	involves: 129S/SvEv * C57BL/6J	MGI:3707982
hm3	Atoh7^tm1Gan/Atoh7^tm1Gan	Not Specified	MGI:3707543
ht4	Atoh7^tm1Gan/Atoh7^{tm1(Neurod1)Whk}	involves: 129S6/SvEvTac * C57BL/6	MGI:3817915
ht5	Atoh7^tm1Gan/Atoh7^{tm2(Neurod4)Whk}	involves: 129S6/SvEvTac * C57BL/6	MGI:3817914
ht6	Atoh7^tm1Gan/Atoh7^tm2Gan	involves: 129S/SvEv * C57BL/6J	MGI:3707983
cx7	Atoh7^tm1Gan/Atoh7^tm1Gan Pou4f2^tm1Nat/Pou4f2^tm1Nat	B6.Cg-Pou4f2^tm1Nat Atoh7^tm1Gan	MGI:3842519

Allelic Composition	Atoh7^tm1Gan/Atoh7^tm1Gan
Genetic Background	B6.Cg-Atoh7^tm1Gan

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm1Gan mutation (0 available); any Atoh7 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

increased retina apoptosis ( J:135827 )

• at E16.5, there is a 65% increase in the number of apoptotic cells compared to controls

optic nerve hypoplasia ( J:135827 )

• a thin optic nerve is observed

abnormal retina morphology ( J:135827 )

• higher number of retinal cells are actively proliferating at E16.5

abnormal Muller cell morphology ( J:135827 )

• Muller cells are mislocalized to the ganglion cell layer and the outer nuclear layer

abnormal retina ganglion cell morphology ( J:135827 )

• projections of ganglions are often disorganized though a few do project into the optic disc

decreased retina ganglion cell number ( J:135827 )

• retinal ganglion cells are decreased by about 95%

abnormal eye electrophysiology ( J:135827 )

• the amplitudes of b waves for both scotopic and phototopic ERG are significantly reduced

• there is also a loss of positive scotopic threshold response

nervous system

abnormal Muller cell morphology ( J:135827 )

• Muller cells are mislocalized to the ganglion cell layer and the outer nuclear layer

abnormal retina ganglion cell morphology ( J:135827 )

• projections of ganglions are often disorganized though a few do project into the optic disc

decreased retina ganglion cell number ( J:135827 )

• retinal ganglion cells are decreased by about 95%

optic nerve hypoplasia ( J:135827 )

• a thin optic nerve is observed

cellular

increased retina apoptosis ( J:135827 )

• at E16.5, there is a 65% increase in the number of apoptotic cells compared to controls

Allelic Composition	Atoh7^tm1Gan/Atoh7^tm1Gan
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm1Gan mutation (0 available); any Atoh7 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:67382 )

N	• mice are fertile

vision/eye

increased amacrine cell number ( J:67382 )

• 7.5-fold increase in the number of ON-starburst (ChAT+) cells most of which are displaced to the ganglion cell layer

• however, bipolar cells are normal in number

nervous system

increased amacrine cell number ( J:67382 )

• 7.5-fold increase in the number of ON-starburst (ChAT+) cells most of which are displaced to the ganglion cell layer

• however, bipolar cells are normal in number

Allelic Composition	Atoh7^tm1Gan/Atoh7^tm1Gan
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm1Gan mutation (0 available); any Atoh7 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

absent retina ganglion cell ( J:141248 )

• at E14.5

increased amacrine cell number ( J:119663 )

• the number of Bhlhb5+ displaced amacrine cells in increased 7-fold at P21

abnormal retina cone bipolar cell morphology ( J:119663 )

• the number of cone bipolar cells is reduced

absent optic nerve ( J:141248 )

nervous system

absent retina ganglion cell ( J:141248 )

• at E14.5

increased amacrine cell number ( J:119663 )

• the number of Bhlhb5+ displaced amacrine cells in increased 7-fold at P21

abnormal retina cone bipolar cell morphology ( J:119663 )

• the number of cone bipolar cells is reduced

absent optic nerve ( J:141248 )

Allelic Composition	Atoh7^tm1Gan/Atoh7^{tm1(Neurod1)Whk}
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm1Gan mutation (0 available); any Atoh7 mutation (9 available)
Atoh7^{tm1(Neurod1)Whk} mutation (0 available); any Atoh7 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

increased retina apoptosis ( J:141248 )

• from E11.5 to E16.5, retinal apoptosis is increased compared to in wild-type mice

decreased retina ganglion cell number ( J:141248 )

• based of expression of retinal ganglion cell (RGC) markers at E13.5, the number of RGCs is 40% of wild-type but increases by E14.5 likely due to delayed RGC differentiation

abnormal optic nerve morphology ( J:141248 )

• at P30 to P40, two-thirds of retinas exhibit greater numbers and higher density of retinal ganglion cell axon bundles compared to in Atoh7^tm1Gan homozygotes with the majority correctly orientated towards the optic disk

optic nerve hypoplasia ( J:141248 )

• mice exhibit severe optic nerve hypoplasia

• at 4 to 5 weeks of age, optic nerve diameters are 50% to 60% of wild-type with substantial restoration of optic nerves

nervous system

decreased retina ganglion cell number ( J:141248 )

• based of expression of retinal ganglion cell (RGC) markers at E13.5, the number of RGCs is 40% of wild-type but increases by E14.5 likely due to delayed RGC differentiation

abnormal optic nerve morphology ( J:141248 )

optic nerve hypoplasia ( J:141248 )

• mice exhibit severe optic nerve hypoplasia

• at 4 to 5 weeks of age, optic nerve diameters are 50% to 60% of wild-type with substantial restoration of optic nerves

cellular

increased retina apoptosis ( J:141248 )

• from E11.5 to E16.5, retinal apoptosis is increased compared to in wild-type mice

Allelic Composition	Atoh7^tm1Gan/Atoh7^{tm2(Neurod4)Whk}
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm1Gan mutation (0 available); any Atoh7 mutation (9 available)
Atoh7^{tm2(Neurod4)Whk} mutation (0 available); any Atoh7 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

decreased retina ganglion cell number ( J:141248 )

• based of expression of retinal ganglion cell (RGC) markers at E13.5, the number of RGCs is 10% of wild-type but increases by E14.5 likely due to delayed RGC differentiation

absent optic nerve ( J:141248 )

nervous system

decreased retina ganglion cell number ( J:141248 )

• based of expression of retinal ganglion cell (RGC) markers at E13.5, the number of RGCs is 10% of wild-type but increases by E14.5 likely due to delayed RGC differentiation

absent optic nerve ( J:141248 )

Allelic Composition	Atoh7^tm1Gan/Atoh7^tm2Gan
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm1Gan mutation (0 available); any Atoh7 mutation (9 available)
Atoh7^tm2Gan mutation (0 available); any Atoh7 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:67382 )

• at E15.5, the ganglion cell layer contains very few differentiated ganglion cells

• however, at E11 and E15.5 the number of progenitor retinal ganglion cells are similar to that in heterozygotes and there is no evidence of increased apoptosis at E12.5 to E19

abnormal retina nerve fiber layer morphology ( J:67382 )

• absence of nerve fiber layer

nervous system

abnormal retina ganglion cell morphology ( J:67382 )

• at E15.5, the ganglion cell layer contains very few differentiated ganglion cells

• however, at E11 and E15.5 the number of progenitor retinal ganglion cells are similar to that in heterozygotes and there is no evidence of increased apoptosis at E12.5 to E19

Allelic Composition	Atoh7^tm1Gan/Atoh7^tm1Gan Pou4f2^tm1Nat/Pou4f2^tm1Nat
Genetic Background	B6.Cg-Pou4f2^tm1Nat Atoh7^tm1Gan

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm1Gan mutation (0 available); any Atoh7 mutation (9 available)
Pou4f2^tm1Nat mutation (0 available); any Pou4f2 mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

increased retina apoptosis ( J:135827 )

• at E16.5, there is a 65% increase in the number of apoptotic cells compared to controls

• at day of birth, apoptotic numbers are 500% greater than in controls

abnormal retina morphology ( J:135827 )

• a higher number of retinal cells are actively proliferating at E16.5

abnormal Muller cell morphology ( J:135827 )

• Muller cells are reduced by about 30%

decreased amacrine cell number ( J:135827 )

• there is a 70% reduction of amacrine cells

abnormal retina rod bipolar cell morphology ( J:135827 )

• rod bipolar cells are reduced by 45% and are found in patches instead of being evenly distributed

abnormal retina ganglion cell morphology ( J:135827 )

• the small number of retinal ganglion cells have small and underdeveloped axons

decreased retina ganglion cell number ( J:135827 )

• retinal ganglion cells are virtually absent with less than 1% of the normal number present

• cells are absent at birth suggesting an early developmental defect

thin retina ganglion layer ( J:135827 )

• the virtual absent of retinal ganglion cells leads to a decrease in layer thickness

thin retina inner nuclear layer ( J:135827 )

• there is a 65% reduction in the number of cells found in the inner nuclear layer including a 70% reduction of amacrine cells

thin retina outer nuclear layer ( J:135827 )

• there is a 50% reduction in the number of cells found in the outer nuclear layer

retina hypoplasia ( J:135827 )

• retinal thickness at the day of birth is reduced by about 50% compared to controls

abnormal eye electrophysiology ( J:135827 )

• b waves are significantly reduced under scotopic conditions and are absent under photopic conditions

nervous system

abnormal Muller cell morphology ( J:135827 )

• Muller cells are reduced by about 30%

decreased amacrine cell number ( J:135827 )

• there is a 70% reduction of amacrine cells

abnormal retina rod bipolar cell morphology ( J:135827 )

• rod bipolar cells are reduced by 45% and are found in patches instead of being evenly distributed

abnormal retina ganglion cell morphology ( J:135827 )

• the small number of retinal ganglion cells have small and underdeveloped axons

decreased retina ganglion cell number ( J:135827 )

• retinal ganglion cells are virtually absent with less than 1% of the normal number present

• cells are absent at birth suggesting an early developmental defect

cellular

increased retina apoptosis ( J:135827 )

• at E16.5, there is a 65% increase in the number of apoptotic cells compared to controls

• at day of birth, apoptotic numbers are 500% greater than in controls

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