All Phenotypes Atoh7<tm1Gla> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atoh7^tm1Gla
targeted mutation 1, Tom Glaser
MGI:2159015

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atoh7^tm1Gla/Atoh7^tm1Gla	B6.129-Atoh7^tm1Gla	MGI:3641415
hm2	Atoh7^tm1Gla/Atoh7^tm1Gla	either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	MGI:3641416
hm3	Atoh7^tm1Gla/Atoh7^tm1Gla	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J	MGI:3641413
hm4	Atoh7^tm1Gla/Atoh7^tm1Gla	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5433340
hm5	Atoh7^tm1Gla/Atoh7^tm1Gla	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1	MGI:3641414
cn6	Atoh7^tm1Gla/Atoh7^tm1Gla Tg(Crx-Atoh7,-cre)60Gla/0 Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL	MGI:5433338
cn7	Atoh7^tm1Gla/Atoh7^tm1Gla Tg(Crx-Atoh7,-cre)251Gla/0 Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL	MGI:5433335

Allelic Composition	Atoh7^tm1Gla/Atoh7^tm1Gla
Genetic Background	B6.129-Atoh7^tm1Gla

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm1Gla mutation (1 available); any Atoh7 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

decreased retina rod cell number ( J:99410 )

• 28% fewer rods

abnormal retina bipolar cell morphology ( J:99410 )

• about 40% fewer Gnao1 positive cells

abnormal retina cone bipolar cell morphology ( J:99410 )

• about 60% fewer recoverin-positive cone OFF bipolar cells and these cells have shorter, more compact presynaptic arbors

abnormal retina rod bipolar cell morphology ( J:99410 )

• about 30% fewer protein kinase C positive rod bipolar cells and these cells have shorter axons

thin retina inner nuclear layer ( J:99410 )

• 45% thinner and the planimetric density is reduced by 38%

thin retina inner plexiform layer ( J:99410 )

• 40% thinner

thin retina outer nuclear layer ( J:99410 )

• 14% thinner and the planimetric density is reduced by 15%

thin retina outer plexiform layer ( J:99410 )

• 12% thinner

abnormal eye electrophysiology ( J:99410 )

• scotopic a- and b-wave and photopic b-wave amplitudes are decreased and a 30-fold brighter stimulus is needed for mutants to achieve the same amplitude as wild-type mice

• the scotopic b-wave is more severely affected than the a-wave

behavior/neurological

abnormal circardian behavior entrainment ( J:99410 )

• activity patterns do not photoentrain indicating the suprachiasmatic nuclei do not entrain; however free-running patterns are similar to wild-type

nervous system

absent optic tract ( J:99410 )

• absent retinohypothalmic tract

decreased retina rod cell number ( J:99410 )

• 28% fewer rods

abnormal retina bipolar cell morphology ( J:99410 )

• about 40% fewer Gnao1 positive cells

abnormal retina cone bipolar cell morphology ( J:99410 )

• about 60% fewer recoverin-positive cone OFF bipolar cells and these cells have shorter, more compact presynaptic arbors

abnormal retina rod bipolar cell morphology ( J:99410 )

• about 30% fewer protein kinase C positive rod bipolar cells and these cells have shorter axons

Allelic Composition	Atoh7^tm1Gla/Atoh7^tm1Gla
Genetic Background	either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm1Gla mutation (1 available); any Atoh7 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina cone cell morphology ( J:110600 )

• at E15.5 the number of RXRG -positive cones is increased and these cells are abnormally arranged

abnormal eye development ( J:110600 )

• retinal birthdating indicates an 80%, 70%, and 78% loss of E11.5 birthdated neurons in the ganglion cell, inner nuclear, and outer nuclear layers, respectively

• an 89% and 90% increase in the number of E13.5 and E15.5 birthdated outer nuclear layer neurons is also seen

• unlike in wild-type eyes E11.5 birthdated Muller glial cells are detected

• expression studies indicate that retinal cells are fail to become fully postmitotic from at least E11.5 to E14.5

cellular

abnormal cell cycle ( J:110600 )

• expression studies indicate that retinal cells are fail to become fully postmitotic from at least E11.5 to E14.5

• at E11.5 in the retina the number of G1/S phase, S phase, and M phase retinal progenitor cells is decreased by 48%, 20% and 37%, respectively, while at E14.5 the number of S phase cells is increased by 34%

nervous system

abnormal retina cone cell morphology ( J:110600 )

• at E15.5 the number of RXRG -positive cones is increased and these cells are abnormally arranged

Allelic Composition	Atoh7^tm1Gla/Atoh7^tm1Gla
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm1Gla mutation (1 available); any Atoh7 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

absent optic nerve ( J:70746 )

• absent optic nerve and chiasma in adults

• at E13.5 and E15.5 no signs of even a rudimentary optic nerve are detected

abnormal eye development ( J:70746 )

• at E13.5 a small number of poorly organized nascent retinal ganglion cells are seen

• at P0.5 increased density of differentiating cones is seen

abnormal optic vesicle formation ( J:70746 )

• no optic stalk remnant is seen in adults

abnormal retina morphology ( J:70746 )

• most eyes have areas of disrupted layering which may include rosettes

abnormal retina vasculature morphology ( J:70746 )

• ectopic blood vessels are seen in the posterior chamber and occasionally in the ganglion cell and the inner plexiform layers

absent retina ganglion layer ( J:70746 )

• at E13.5, no well formed layer is seen and the few axons that are present are not bundled into nerve fibers

thin retina inner nuclear layer ( J:70746 )

• thinner

thin retina inner plexiform layer ( J:70746 )

• thinner

decreased total retina thickness ( J:70746 )

• 20-25% thinner, primarily the result of decreased width of the inner plexiform and inner nuclear layers

cardiovascular system

abnormal blood vessel morphology ( J:70746 )

• the central artery and vein which enter the eye via the optic nerve are absent

abnormal retina vasculature morphology ( J:70746 )

• ectopic blood vessels are seen in the posterior chamber and occasionally in the ganglion cell and the inner plexiform layers

nervous system

absent optic nerve ( J:70746 )

• absent optic nerve and chiasma in adults

• at E13.5 and E15.5 no signs of even a rudimentary optic nerve are detected

Allelic Composition	Atoh7^tm1Gla/Atoh7^tm1Gla
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm1Gla mutation (1 available); any Atoh7 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

absent optic nerve ( J:186563 )

• no optic nerve develops

abnormal retina morphology ( J:186563 )

• cell death is significantly increased relative to controls

abnormal retina nerve fiber layer morphology ( J:186563 )

nervous system

absent optic nerve ( J:186563 )

• no optic nerve develops

Allelic Composition	Atoh7^tm1Gla/Atoh7^tm1Gla
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm1Gla mutation (1 available); any Atoh7 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

increased retina cone cell number ( J:70746 )

• cone abundance is increased by about 75% and cells are found in clusters or ectopically in the outer segment layer

abnormal amacrine cell morphology ( J:70746 )

• A2 amacrines are decreased and dopaminergic amacrines appear to be absent; however the overall number of amacrine cells is similar to wild-type

abnormal retina ganglion layer morphology ( J:70746 )

• decreased cell number in layer resulting from absence of ganglion cells and axon bundles

• most or all of the cells in the remaining in the ganglion cell layer are amacrine cells

absent retina ganglion cell ( J:70746 )

• absence of ganglion cells and axon bundles

nervous system

absent retina ganglion cell ( J:70746 )

• absence of ganglion cells and axon bundles

increased retina cone cell number ( J:70746 )

• cone abundance is increased by about 75% and cells are found in clusters or ectopically in the outer segment layer

abnormal amacrine cell morphology ( J:70746 )

• A2 amacrines are decreased and dopaminergic amacrines appear to be absent; however the overall number of amacrine cells is similar to wild-type

Allelic Composition	Atoh7^tm1Gla/Atoh7^tm1Gla Tg(Crx-Atoh7,-cre)60Gla/0 Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atoh7^tm1Gla mutation (1 available); any Atoh7 mutation (9 available)
Gt(ROSA)26Sor^tm1Sho mutation (4 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Crx-Atoh7,-cre)60Gla mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal optic nerve innervation ( J:186563 )

• knots of retinal ganglion cell axons are observed, consistent with the small degree of rescue

abnormal retina nerve fiber layer morphology ( J:186563 )

• the BAC Crx-Atoh7 (Crx-Math5) construct shows some rescue of retinal axons and prevention of fasciculation defects in double mutants compared to Atoh7 homozygotes; level of rescue is lower than that seen in Atoh7-null homozygotes crossed to the conventional transgenic Atoh7 mice (Tg(Crx-Atoh7,-cre)251Gla)

• rescue is less pronounced with successive generations

nervous system

abnormal optic nerve innervation ( J:186563 )

• knots of retinal ganglion cell axons are observed, consistent with the small degree of rescue

Allelic Composition	Atoh7^tm1Gla/Atoh7^tm1Gla Tg(Crx-Atoh7,-cre)251Gla/0 Gt(ROSA)26Sor^tm1Sho/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal optic nerve morphology ( J:186563 )

• animals much thinner optic nerves relative to controls

abnormal optic nerve innervation ( J:186563 )

• in some animals, severe pathfinding defects are observed as the optic nerve exits the retina, forming a knot-like structure

abnormal retina ganglion layer morphology ( J:186563 )

• cell death is increased relative to Atoh7-null homozygotes with most dying cells observed in the ganglion cell layer (GCL)

abnormal retina nerve fiber layer morphology ( J:186563 )

• the transgenic Crx-Atoh7 (Math5) construct shows variable rescue of retinal axons and prevention of fasciculation defects in double mutants compared to Atoh7-null homozygotes

• rescue is less pronounced with successive generations

nervous system

abnormal optic nerve morphology ( J:186563 )

• animals much thinner optic nerves relative to controls

abnormal optic nerve innervation ( J:186563 )

• in some animals, severe pathfinding defects are observed as the optic nerve exits the retina, forming a knot-like structure

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