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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cnga2tm1Mom
targeted mutation 1, Peter Mombaerts
MGI:2159016
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cnga2tm1Mom/Cnga2tm1Mom involves: 129P2/OlaHsd * C57BL/6J MGI:3718343
cx2
 		Cnga2tm1Mom/Cnga2tm1Mom
Or8a1tm2Mom/Or8a1tm4Mom 		involves: 129P2/OlaHsd * C57BL/6 MGI:3694207
cx3
 		Cnga2tm1Mom/Cnga2tm1Mom
Or8a1btm4Mom/Or8a1b+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:3718347
cx4
 		Cnga2tm1Mom/Y
Or8a1btm4Mom/Or8a1b+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:3718349
cx5
 		Cnga2tm1Mom/Cnga2tm1Mom
Trpc2tm2Mom/Trpc2tm2Mom 		involves: 129P2/OlaHsd * C57BL/6J MGI:5804192
cx6
 		Cnga2tm1Mom/Y
Trpc2tm2Mom/Trpc2tm2Mom 		involves: 129P2/OlaHsd * C57BL/6J MGI:5804197
cx7
 		Cnga2tm1Mom/Cnga2tm1Mom
Or8a1btm5(Cnga2)Mom/Or8a1b+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:3718345
cx8
 		Cnga2tm1Mom/Y
Or8a1btm5(Cnga2)Mom/Or8a1b+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:3718346
cx9
 		Cnga2tm1Mom/Cnga2tm1Mom
S100a5tm1.1Mom/? 		involves: 129P2/OlaHsd * C57BL/6J * FVB/N MGI:5605395
ot10
 		Cnga2tm1Mom/Y involves: 129P2/OlaHsd * C57BL/6J MGI:3718342


Genotype
MGI:3718343
hm1
Allelic
Composition		 Cnga2tm1Mom/Cnga2tm1Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation (2 available); any Cnga2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:67661 )
• mice die within 2 days of birth unless normal littermates are removed thereby reducing competition for milk
• however, if normal littermates are removed mice survive into adulthood

taste/olfaction
abnormal olfactory system physiology ( J:67661 )
• olfactory neurons are not responsive to forskolin

growth/size/body
postnatal growth retardation ( J:67661 )
• mice fail to thrive after birth

nervous system
abnormal neuron physiology ( J:67661 )
• olfactory neurons are not responsive to forskolin




Genotype
MGI:3694207
cx2
Allelic
Composition		 Cnga2tm1Mom/Cnga2tm1Mom
Or8a1tm2Mom/Or8a1tm4Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation (2 available); any Cnga2 mutation (17 available)
Or8a1tm2Mom mutation (1 available); any Or8a1 mutation (69 available)
Or8a1tm4Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory neuron innervation pattern ( J:90716 )
• Hyb B and Hyb D axons segregate into separate into separate compartments within the same glomeruli




Genotype
MGI:3718347
cx3
Allelic
Composition		 Cnga2tm1Mom/Cnga2tm1Mom
Or8a1btm4Mom/Or8a1b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation (2 available); any Cnga2 mutation (17 available)
Or8a1btm4Mom mutation (1 available); any Or8a1b mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
abnormal olfactory bulb morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• Olfr160+ glomeruli are localized more ventrally than in wild-type mice
• at day 7, extra minor glomeruli are observed
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or to continue to grow past the glomerulus layer into the deep layers of the bulb

craniofacial
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb

respiratory system
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb

growth/size/body
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb




Genotype
MGI:3718349
cx4
Allelic
Composition		 Cnga2tm1Mom/Y
Or8a1btm4Mom/Or8a1b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation (2 available); any Cnga2 mutation (17 available)
Or8a1btm4Mom mutation (1 available); any Or8a1b mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
abnormal olfactory bulb morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• Olfr160+ glomeruli are localized more ventrally than in wild-type mice
• at day 7, extra minor glomeruli are observed
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or to continue to grow past the glomerulus layer into the deep layers of the bulb

craniofacial
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb

respiratory system
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb

growth/size/body
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb




Genotype
MGI:5804192
cx5
Allelic
Composition		 Cnga2tm1Mom/Cnga2tm1Mom
Trpc2tm2Mom/Trpc2tm2Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation (2 available); any Cnga2 mutation (17 available)
Trpc2tm2Mom mutation (1 available); any Trpc2 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron physiology ( J:235858 )
• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent

taste/olfaction
abnormal olfactory sensory neuron physiology ( J:235858 )
• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent

respiratory system
abnormal olfactory sensory neuron physiology ( J:235858 )
• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent




Genotype
MGI:5804197
cx6
Allelic
Composition		 Cnga2tm1Mom/Y
Trpc2tm2Mom/Trpc2tm2Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation (2 available); any Cnga2 mutation (17 available)
Trpc2tm2Mom mutation (1 available); any Trpc2 mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron physiology ( J:235858 )
• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent

taste/olfaction
abnormal olfactory sensory neuron physiology ( J:235858 )
• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent

respiratory system
abnormal olfactory sensory neuron physiology ( J:235858 )
• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent




Genotype
MGI:3718345
cx7
Allelic
Composition		 Cnga2tm1Mom/Cnga2tm1Mom
Or8a1btm5(Cnga2)Mom/Or8a1b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation (2 available); any Cnga2 mutation (17 available)
Or8a1btm5(Cnga2)Mom mutation (1 available); any Or8a1b mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal olfactory system physiology ( J:67661 )
• olfactory neurons are not responsive to forskolin

nervous system
abnormal neuron physiology ( J:67661 )
• olfactory neurons are not responsive to forskolin




Genotype
MGI:3718346
cx8
Allelic
Composition		 Cnga2tm1Mom/Y
Or8a1btm5(Cnga2)Mom/Or8a1b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation (2 available); any Cnga2 mutation (17 available)
Or8a1btm5(Cnga2)Mom mutation (1 available); any Or8a1b mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal olfactory system physiology ( J:67661 )
• olfactory neurons are not responsive to forskolin

nervous system
abnormal neuron physiology ( J:67661 )
• olfactory neurons are not responsive to forskolin




Genotype
MGI:5605395
cx9
Allelic
Composition		 Cnga2tm1Mom/Cnga2tm1Mom
S100a5tm1.1Mom/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation (2 available); any Cnga2 mutation (17 available)
S100a5tm1.1Mom mutation (1 available); any S100a5 mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron physiology ( J:215302 )
• S100A5 driven GFP fluorescence is nearly undetectable in odorant stimulated olfactory sensory neurons null for CNGA2 indicating that CNGA2 is required for activation of S100A5

taste/olfaction
abnormal olfactory sensory neuron physiology ( J:215302 )
• S100A5 driven GFP fluorescence is nearly undetectable in odorant stimulated olfactory sensory neurons null for CNGA2 indicating that CNGA2 is required for activation of S100A5

respiratory system
abnormal olfactory sensory neuron physiology ( J:215302 )
• S100A5 driven GFP fluorescence is nearly undetectable in odorant stimulated olfactory sensory neurons null for CNGA2 indicating that CNGA2 is required for activation of S100A5




Genotype
MGI:3718342
ot10
Allelic
Composition		 Cnga2tm1Mom/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation (2 available); any Cnga2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:67661 )
• mice die within 2 days of birth unless normal littermates are removed thereby reducing competition for milk
• however, if normal littermates are removed mice survive into adulthood

taste/olfaction
abnormal olfactory system physiology ( J:67661 )
• olfactory neurons are not responsive to forskolin

growth/size/body
postnatal growth retardation ( J:67661 )
• mice fail to thrive after birth

nervous system
abnormal neuron physiology ( J:67661 )
• olfactory neurons are not responsive to forskolin




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory