All Phenotypes Neurog3<tm1Fgu> MGI Mouse

postnatal lethality, incomplete penetrance ( J:161480 )

• 50% of mice die within the first 8 days of life

abnormal intestinal goblet cell morphology ( J:161480 )

• goblet cells in the large intestine are larger than in wild-type mice and mostly devoid of mucus

• however, goblet cell numbers are normal in the small intestine

abnormal small intestinal crypt cell proliferation ( J:161480 )

• at E19.5, crypt cell proliferation is increased compared to in wild-type mice

• in adult mice, crypt cell proliferation is increased with an up to 1.6-fold increase in cell turnover compared to in wild-type mice

abnormal intestine development ( J:161480 )

• as early as embryogenesis, mice lack enteroendocrine progenitors along the proximal-distal axis of the intestine unlike in wild-type mice

• however, intestinal epithelial cell proliferation is normal

abnormal intestinal enteroendocrine cell morphology ( J:161480 )

• as early as embryogenesis, mice lack enteroendocrine progenitors along the proximal-distal axis of the intestine unlike in wild-type mice

steatorrhea ( J:161480 )

• mice excrete yellowish stool unlike wild-type mice

diarrhea ( J:161480 )

• surviving mice exhibit soft stool that does not cease with age unlike in wild-type mice

abnormal small intestine crypts of Lieberkuhn morphology ( J:161480 )

• small intestine crypts are disorganized, larger, and more abundant than in wild-type mice

abnormal large intestine morphology ( J:161480 )

• the large intestine exhibits a reduction in the length of glands of up to 1.5 times compared with wild-type mice

abnormal small intestinal villus morphology ( J:161480 )

• villi are blunted or club shaped with frequent dilation and strong detachment of the epithelium from the basement membrane unlike in wild-type mice

abnormal small intestinal microvillus morphology ( J:161480 )

• microvilli on absorptive cells are sparser, 60% shorter, but twice as large as on wild-type cells

• the brush border of absorptive cells in the small intestine is reduced 44% compared to in wild-type mice

• however, expression of brush border enzymes and glucose transporters is normal

decreased small intestinal microvillus size ( J:161480 )

• 60% shorter than in wild-type mice

increased defecation amount ( J:161480 )

• mice produce more feces compared with wild-type mice

abnormal intestinal lipid absorption ( J:161480 )

• impaired

abnormal intestinal transit time ( J:161480 )

• intestinal transit time is increased 2.3-fold compared to in wild-type mice

steatorrhea ( J:161480 )

• mice excrete yellowish stool unlike wild-type mice

abnormal intestinal lipid absorption ( J:161480 )

• impaired

increased blood urea nitrogen level ( J:161480 )

• slightly

increased circulating bicarbonate level ( J:161480 )

• slightly

decreased circulating glucose level ( J:161480 )

• in an intraperitoneal glucose tolerance test, mice exhibit lower serum glucose levels than in similarly treated wild-type mice

• fasting mice exhibit decreased blood glucose compared with similarly treated wild-type mice

decreased circulating cholesterol level ( J:161480 )

decreased circulating HDL cholesterol level ( J:161480 )

decreased circulating triglyceride level ( J:161480 )

decreased circulating serum albumin level ( J:161480 )

improved glucose tolerance ( J:161480 )

• in an oral glucose tolerance test, mice exhibit improved glucose clearance compared with similarly treated wild-type mice

• in an intraperitoneal glucose tolerance test, mice exhibit lower serum glucose levels than in similarly treated wild-type mice

increased insulin sensitivity ( J:161480 )

• slightly at 14 and 17 weeks

• insulin-mediated hypoglycemic response is blunted compared to in wild-type mice

decreased birth weight ( J:161480 )

decreased body mass index ( J:161480 )

increased lean body mass ( J:161480 )

decreased body size ( J:161480 )

postnatal growth retardation ( J:161480 )

decreased total body fat amount ( J:161480 )

abnormal abdominal fat pad morphology ( J:161480 )

• mice exhibit reduced abdominal fat compared with wild-type mice

abnormal small intestine crypts of Lieberkuhn morphology ( J:161480 )

• small intestine crypts are disorganized, larger, and more abundant than in wild-type mice

abnormal pancreatic islet morphology ( J:161480 )

• mice exhibit more medium and large islets with centrally located alpha cells than in wild-type mice

small pancreatic islets ( J:161480 )

• mice exhibit a shift from large to single islets compared with wild-type mice