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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(B2M)55Hpl
transgene insertion 55, Hidde Ploegh
MGI:2159101
Summary 5 genotypes


Genotype
MGI:3835121
cx1
Allelic
Composition		 Tg(B2M)55Hpl/?
Tg(CD8aCD8b)57Scr/?
Tg(HLA-B)22Hpl/?
Genetic
Background		 involves: C57BL/6 * C57BL/LiA * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(B2M)55Hpl mutation (6 available)
Tg(CD8aCD8b)57Scr mutation (1 available)
Tg(HLA-B)22Hpl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytotoxic T cell physiology ( J:127813 )
• infection with measles virus (MV) generates a large cytotoxic T cell population that can target human cells presenting MV antigens in the context of HLA-B27
• these HLA-B27-restricted CTLs have high affinity for MV antigens with half maximal CTL-mediated lysis of target cells occurring at low (3x10 M-8) peptide concentrations
• these CTLs fail to generate a cytotoxic response against target cells with HLA-A2 haplotype

hematopoietic system
abnormal cytotoxic T cell physiology ( J:127813 )
• infection with measles virus (MV) generates a large cytotoxic T cell population that can target human cells presenting MV antigens in the context of HLA-B27
• these HLA-B27-restricted CTLs have high affinity for MV antigens with half maximal CTL-mediated lysis of target cells occurring at low (3x10 M-8) peptide concentrations
• these CTLs fail to generate a cytotoxic response against target cells with HLA-A2 haplotype




Genotype
MGI:5707036
cx2
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Emv30b/Emv30b
Prkdcscid/Prkdcscid
Tg(B2M)55Hpl/?
Mcph1Tg(HLA-A2.1)1Enge/?
Genetic
Background		 NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Emv30b Prkdcscid Tg(B2M)55Hpl/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Emv30b mutation (3 available); any Emv30 mutation (3 available)
Mcph1Tg(HLA-A2.1)1Enge mutation (7 available); any Mcph1 mutation (58 available)
Prkdcscid mutation (178 available); any Prkdc mutation (417 available)
Tg(B2M)55Hpl mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:109851 )
• these mice do not develop diabetes and they provide a host in cell transfer studies for assessing HLA-A2.1 selected T cell pathogenicity




Genotype
MGI:3723607
cx3
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Tg(B2M)55Hpl/Tg(B2M)55Hpl
Mcph1Tg(HLA-A2.1)1Enge/Mcph1Tg(HLA-A2.1)1Enge
Genetic
Background		 NOD.Cg-B2mtm1Unc Mcph1Tg(HLA-A2.1)1Enge Tg(B2M)55Hpl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Mcph1Tg(HLA-A2.1)1Enge mutation (7 available); any Mcph1 mutation (58 available)
Tg(B2M)55Hpl mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:109851 )
• mice develop diabetes at a rate similar to NOD control females, whereas transgenic animals not expressing Tg(HLA-A2.1)1Enge are normally diabetes-resistant




Genotype
MGI:3844912
cx4
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Tg(B2M)55Hpl/0
Genetic
Background		 NOD.Cg-B2mtm1Unc Tg(B2M)55Hpl/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Tg(B2M)55Hpl mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:71837 )
N
• mice exhibit normal class I disparate skin graft rejection and viral infection clearance

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:71837 )
N
• mice fail to develop insulitis unlike NOD mice




Genotype
MGI:3844698
cx5
Allelic
Composition		 Prkdcscid/Prkdcscid
Tg(B2M)55Hpl/0
Mcph1Tg(HLA-A2.1)1Enge/Mcph1+
Genetic
Background		 NOD.Cg-Mcph1Tg(HLA-A2.1)1Enge Prkdcscid Tg(B2M)55Hpl/Sz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcph1Tg(HLA-A2.1)1Enge mutation (7 available); any Mcph1 mutation (58 available)
Prkdcscid mutation (178 available); any Prkdc mutation (417 available)
Tg(B2M)55Hpl mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating glucose level ( J:91764 )
• when islet and HLA-A2 negative human peripheral blood mononuclear cells are transplanted into streptozotocin-treated Rag1tm1Mom Prf1tm1Sdz homozygotes serum glucose remains high
• however, when islet and HLA-A2 positive human peripheral blood mononuclear cells are transplanted into streptozotocin-treated Rag1tm1Mom Prf1tm1Sdz homozygotes euglycemia is achieved

immune system
abnormal response to transplant ( J:91764 )
• when islet and HLA-A2 negative human peripheral blood mononuclear cells are transplanted into streptozotocin-treated Rag1tm1Mom Prf1tm1Sdz homozygotes engrafted islet cells are destroyed




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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory