All Phenotypes Tg(Rarb-cre)1Mrc MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Rarb-cre)1Mrc
transgene insertion 1, Mario R Capecchi
MGI:2159107

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Wnt3^tm1Amc/Wnt3^tm2Amc Tg(Rarb-cre)1Mrc/0	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ	MGI:2450913
cn2	Fgf4^tm1Mrc/Fgf4^tm1.1Mrc Tg(Rarb-cre)1Mrc/0	involves: 129S1/Sv * 129X1/SvJ	MGI:3713885
cn3	Fgf4^tm1Mrc/Fgf4^tm2Mrc Tg(Rarb-cre)1Mrc/0	involves: 129S1/Sv * 129X1/SvJ	MGI:2176789
cn4	Fgf8^tm1Mrc/Fgf8^tm2Mrc Tg(Rarb-cre)1Mrc/0	Not Specified	MGI:2176855
cn5	Aldh1a2^tm1Dll/Aldh1a2^tm1Ipc Tg(Rarb-cre)1Mrc/0	Not Specified	MGI:3575693

Allelic Composition	Wnt3^tm1Amc/Wnt3^tm2Amc Tg(Rarb-cre)1Mrc/0
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Rarb-cre)1Mrc mutation (1 available)
Wnt3^tm1Amc mutation (0 available); any Wnt3 mutation (25 available)
Wnt3^tm2Amc mutation (0 available); any Wnt3 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal apical ectodermal ridge morphology ( J:81795 )

• at E10.5, mutant mice exhibit a reduction in the anterior/posterior length of the AER

abnormal forelimb morphology ( J:81795 )

• mutant mice display variable forelimb defects ranging from three digits (anterior digits 1-3) and normal zeugopod (radius and ulna) to one digit (digit 2 or 3) and also zeugopod defects (missing ulna); in most cases, the humerus appears unaffected

embryo

abnormal apical ectodermal ridge morphology ( J:81795 )

• at E10.5, mutant mice exhibit a reduction in the anterior/posterior length of the AER

Allelic Composition	Fgf4^tm1Mrc/Fgf4^tm1.1Mrc Tg(Rarb-cre)1Mrc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf4^tm1.1Mrc mutation (0 available); any Fgf4 mutation (30 available)
Fgf4^tm1Mrc mutation (0 available); any Fgf4 mutation (30 available)
Tg(Rarb-cre)1Mrc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:60091 )

N	• mutants at E15.5, at birth, and as adults have normal forelimbs

Allelic Composition	Fgf4^tm1Mrc/Fgf4^tm2Mrc Tg(Rarb-cre)1Mrc/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf4^tm1Mrc mutation (0 available); any Fgf4 mutation (30 available)
Fgf4^tm2Mrc mutation (0 available); any Fgf4 mutation (30 available)
Tg(Rarb-cre)1Mrc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

limbs/digits/tail phenotype ( J:60091 )

N	• no abnormal limbs/digits/tail phenotypes detected

skeleton

skeleton phenotype ( J:60091 )

N	• no abnormal skeleton phenotypes detected

Allelic Composition	Fgf8^tm1Mrc/Fgf8^tm2Mrc Tg(Rarb-cre)1Mrc/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8^tm1Mrc mutation (0 available); any Fgf8 mutation (21 available)
Fgf8^tm2Mrc mutation (0 available); any Fgf8 mutation (21 available)
Tg(Rarb-cre)1Mrc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:66265 )

abnormal digit morphology ( J:66265 )

abnormal limb bone morphology ( J:66265 )

skeleton

abnormal limb bone morphology ( J:66265 )

Allelic Composition	Aldh1a2^tm1Dll/Aldh1a2^tm1Ipc Tg(Rarb-cre)1Mrc/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a2^tm1Dll mutation (0 available); any Aldh1a2 mutation (38 available)
Aldh1a2^tm1Ipc mutation (0 available); any Aldh1a2 mutation (38 available)
Tg(Rarb-cre)1Mrc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:97213 )

• abnormal flexure of the forepaw digits, especially of second and third digits

syndactyly ( J:97213 )

• partial syndactyly of the second to forth forelimb digits

muscle

muscle phenotype ( J:97213 )

N	• no defect in the size and topology of distal limb muscle groups and their intersections, except for a slight hypoplasia of the extensor radialis muscles

skeleton

skeleton phenotype ( J:97213 )

N	• no defect in digit skeleton

nervous system

abnormal motor neuron innervation pattern ( J:97213 )

• an early embryonic loss of a subset of Lim1+ brachial motoneurons, a mispositioning of Islet1+ neurons and inappropriate axonal projections of the nerves innervating extensor limb muscles

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