Phenotypes associated with this allele

• Allele Symbol: Cnga2^tm1Gvr
• Allele Name: targeted mutation 1, Gabriele V Ronnett
• Allele ID: MGI:2159208
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cnga2^tm1Gvr/Cnga2^tm1Gvr	involves: 129 * C57BL/6	MGI:3851509
ot2	Cnga2^tm1Gvr/Y	involves: 129 * 129S1/SvImJ * C57BL/6J	MGI:3851516
ot3	Cnga2^tm1Gvr/Y	involves: 129 * C57BL/6	MGI:3851510

Genotype
MGI:3851509

hm1

• Allelic Composition: Cnga2^tm1Gvr/Cnga2^tm1Gvr
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:74854 )

♀ • mice exhibit a high level of neonatal lethality

♀ • however, litter size reduction within the first 24 hours after birth reduces neonatal lethality

nervous system

reduced long-term potentiation ( J:74854 )

♀ • long term potentiation induced by theta-burst stimulation is attenuated compared to in wild-type mice

♀ • however, long term potentiation induced by high-frequency stimulation is normal

decreased post-tetanic potentiation ( J:74854 )

♀ • after theta burst stimulation, the field excitatory postsynaptic potential slope at the first pulse of the third theta-burst set is less than in wild-type mice

Genotype
MGI:3851516

ot2

• Allelic Composition: Cnga2^tm1Gvr/Y
• Genetic Background: involves: 129 * 129S1/SvImJ * C57BL/6J

mortality/aging

neonatal lethality, incomplete penetrance ( J:58158 )

♂ • mice exhibit a high level of neonatal lethality

♂ • however, litter size reduction within the first 24 hours after birth reduces neonatal lethality

nervous system

abnormal olfactory bulb morphology ( J:58158 )

♂ • the external plexiform layer is reduced in thickness by 55% compared to in wild-type mice

♂ • the septal receptor epithelium is 15% thinner than in wild-type mice

♂ • mice exhibit smaller glomerular and granule cell layers and decreased olfactory bulb length compared with wild-type mice

♂ • fibers in the olfactory bulb are more disorganized than in wild-type mice

small olfactory bulb ( J:58158 )

♂ • mice exhibit narrower laminae than in wild-type mice with the biggest difference observed in the external plexiform layer

abnormal olfactory nerve morphology ( J:58158 )

♂ • fewer olfactory receptor cells innervate the olfactory bulb compared to in wild-type mice

♂ • fewer TH+ neurons are found in the olfactory bulb compared to in wild-type mice

♂ • the olfactory bulb contains fewer mature and immature neurons compared to in wild-type mice

Genotype
MGI:3851510

ot3

• Allelic Composition: Cnga2^tm1Gvr/Y
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

neonatal lethality, incomplete penetrance ( J:74854 )

♂ • mice exhibit a high level of neonatal lethality

♂ • however, litter size reduction within the first 24 hours after birth reduces neonatal lethality

nervous system

reduced long-term potentiation ( J:74854 )

♂ • long term potentiation induced by theta-burst stimulation is attenuated compared to in wild-type mice

♂ • however, long term potentiation induced by high-frequency stimulation is normal

decreased post-tetanic potentiation ( J:74854 )

♂ • after theta burst stimulation, the field excitatory postsynaptic potential slope at the first pulse of the third theta-burst set is less than in wild-type mice