Phenotypes associated with this allele

• Allele Symbol: Vax2^tm1Sba
• Allele Name: targeted mutation 1, Sandro Banfi
• Allele ID: MGI:2159246
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vax2^tm1Sba/Vax2^tm1Sba	either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * CD-1)	MGI:2177021

Genotype
MGI:2177021

hm1

• Allelic Composition: Vax2^tm1Sba/Vax2^tm1Sba
• Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:74241 )

• loss of ipsilateral projections of retinal ganglion cell axons

• reduced number of contralateral projections terminating in the medial region of the colliculus

• increased number of contralateral projections terminating in the lateral region of the colliculus

coloboma ( J:74241 )

• due to non closure of the optic fissure

• variable severity and either bilateral or unilateral

• Background Sensitivity: higher incidence of bilateral coloboma on CD1 background (46%) than on a C57BL/6 background (17%)

• 70% of mice display some degree of coloboma

• retina otherwise normal and normally stratified

nervous system

abnormal retina ganglion cell morphology ( J:74241 )

• loss of ipsilateral projections of retinal ganglion cell axons

• reduced number of contralateral projections terminating in the medial region of the colliculus

• increased number of contralateral projections terminating in the lateral region of the colliculus