All Phenotypes Nr0b1<tm1Lja> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nr0b1^tm1Lja
targeted mutation 1, J Larry Jameson
MGI:2159305

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cyp11b2^{tm1.1(cre)Brlt}/Cyp11b2⁺ Nr0b1^tm1Lja/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5550088
ot2	Nr0b1^tm1Lja/Y	C57BL/6JEi	MGI:3584271
ot3	Nr0b1^tm1Lja/Y	involves: C57BL/6JEi * DBA/2J	MGI:3584281

Allelic Composition	Cyp11b2^{tm1.1(cre)Brlt}/Cyp11b2⁺ Nr0b1^tm1Lja/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp11b2^{tm1.1(cre)Brlt} mutation (0 available); any Cyp11b2 mutation (41 available)
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (993 available)
Nr0b1^tm1Lja mutation (2 available); any Nr0b1 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:204614 )

N	• loss of Nr0b1 does not impact ability of zona glomerusa cells to contribute to the inner zona fasciculata even at 8 months of age; postnatal zonation and lineage conversion in the adrenal gland are normal

Allelic Composition	Nr0b1^tm1Lja/Y
Genetic Background	C57BL/6JEi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr0b1^tm1Lja mutation (2 available); any Nr0b1 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal primary sex determination ( J:98922 )

primary sex reversal ( J:98922 )

• Background Sensitivity: complete male to female sex-reversal is observed

• Background Sensitivity: QTLs from B6 Chr4, Chr1, and a genetic interaction between Chr1 and Chr8 are implicated in the sex reversal

Allelic Composition	Nr0b1^tm1Lja/Y
Genetic Background	involves: C57BL/6JEi * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr0b1^tm1Lja mutation (2 available); any Nr0b1 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal primary sex determination ( J:98922 )

• Background Sensitivity: in the presence of a Mus domesticus poschiavinus Y chromosome, this background produces XY mice with the following gonad development: 13.8% have testes; 70.7% contain both ovarian and testicular tissue and 15.5% are completely sex-reversed.

ovotestis ( J:98922 )

• Background Sensitivity: partial sex reversal was seen with 70.7% of the hemizygotes having at least one ovotestis.

primary sex reversal ( J:98922 )

• Background Sensitivity: on this background 15.5% of the hemizygotes show male to female sex reversal.

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