Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tektm1Dmt targeted mutation 1, Daniel J Dumont MGI:2159357 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygous embryos are present at E9.5 but absent at E10.5
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• gaps are seen in the blood vessel walls in the head and electron microscopy revealed gaps in the vascular endothelial cells of the perinuclear plexus in the head
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• no pericytes are found around the vascular endothelial cells
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• vascular branching and sprouting are impaired and the complexity of the vascular network is decreased
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• absent myocardial trabeculations at E9.5
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• at E9.5 the endothelium lining the myocardium is less intricately folded and the endocardial lining appears collapsed and retracted from the myocardial wall
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• most homozygous embryos have hemorrhages in the head
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• at E9.5 the vitteline vasculature fails to reorganize into a mature branched network; however, the immature plexus forms normally
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• multilineage hematopoietic stem cell clusters in the omphalomesenteric and vitelline arteries are absent and the number of hematopoietic cells produced in vitro is severely reduced
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• most homozygous embryos have hemorrhages in the head
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• absent myocardial trabeculations at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 16 somite stage, thinning of the dorsal aorta and aberrant ventral arteries seen
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• heart is surrounded by a distended pericardium by E9.5
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• by E9.5, local ruptures in the vasculature and leakage of blood into the body cavity occurred
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• endothelial cells failed to reorganize into a vascular network
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die by E10.5
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• blood vessels in the dorsal, posterior portion of the mouse are enlarged and highly distorted compared to in wild-type mice
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• blood vessel development fails to proceed to the dorsal portion of the body unlike in wild-type mice
• vessel integrity is compromised compared to in wild-type mice
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• mice exhibit poor branching structures of the blood vessels in the head unlike wild-type mice
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• blood vessels fail to organize into large and small vessels unlike in wild-type mice
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• yolk sac vasculature is underdeveloped and lacks major blood vessels unlike in wild-type mice
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• myocardial trabeculation in the ventricle is absent
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• at E9.5, heart development is poor
• mice exhibit reduced endocardial tissue in the common atrial and ventricular chambers compared to in wild-type mice
• mice exhibit thin myocardial layer, poor maintenance of endocardial contact, and absence of trabeculations unlike in wild-type mice
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• yolk sac vasculature is underdeveloped and lacks major blood vessels unlike in wild-type mice
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• at E9.5
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• somites are disorganized and necrotic unlike in wild-type mice
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• at E9.5, necrotic tissue is occasionally observed
• at E10.5, necrosis is widespread
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• remodeling of primary yolk sac capillary plexus fails
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• at E9.5
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• myocardial trabeculation in the ventricle is absent
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• underdeveloped at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die by E10.5
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• at E9.5
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• maintenance of blood vessels in the head and extremities is poor
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• atrial and ventricular endocardium is poorly maintained
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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