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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tie1tm1Sato
targeted mutation 1, Thomas N Sato
MGI:2159359
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tie1tm1Sato/Tie1tm1Sato either: (involves: 129S1/Sv * 129T2/SvEmsJ) or (involves: 129S1/Sv * C57BL/6J) MGI:3612283
hm2
Tie1tm1Sato/Tie1tm1Sato involves: 129S1/Sv * C57BL/6J MGI:3612284


Genotype
MGI:3612283
hm1
Allelic
Composition
Tie1tm1Sato/Tie1tm1Sato
Genetic
Background
either: (involves: 129S1/Sv * 129T2/SvEmsJ) or (involves: 129S1/Sv * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tie1tm1Sato mutation (0 available); any Tie1 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die immediately after birth

respiratory system
• seen at birth
• alveoli are unexpanded possibly a result of pulmonary edema

cardiovascular system
• vascular patterning appears normal; however, at E13.5 vascular endothelial cells that are abnormally electron light are seen
• more immature endocardial cells are seen compared to wild-type mice
• the heart is small at birth but appears grossly morphologically normal at E13.5
• at E13.5 subcutaneous hemorrhage is seen on the back of dead embryos (4 of 27)
• at birth, hemorrhages are seen in the tail tip, and in some mice in the toe tips and sagital sinus of the head and back, also internal hemorrhages are also seen in many organs including the intestine and stomach
• erythrocytes extravasate through the endothelial cells not through the tight junctions between these cells

homeostasis/metabolism
• seen at birth
• seen at birth
• subcutaneous edema of the back is seen at E13.5 in living embryos and at birth

digestive/alimentary system
• seen at birth

integument
• subcutaneous edema of the back is seen at E13.5 in living embryos and at birth




Genotype
MGI:3612284
hm2
Allelic
Composition
Tie1tm1Sato/Tie1tm1Sato
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tie1tm1Sato mutation (0 available); any Tie1 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E15.5 and E18.5 a 1.5- to 2-fold increase in the number of vessels is seen in the brain, kidney, skin, lungs, intestine, and atrium of the heart
• more vascular endothelial cells are hyperactive producing more extensions and filopodia, these connect to tissue folds that eventually divide the vessels, these cells are confined to a smaller subset of vessels in wild-type mice
• intra- and transcellular holes are common in these hyperactive cells
• the papillary muscles are smaller and the atrial wall is thinner
• the endocardium surrounding papillary muscles has a more complex structure

digestive/alimentary system
• the capillary network in the small intestine is more complex and overexpanded compared to wild-type mice

renal/urinary system
• the number of glomeruli is increased

respiratory system
• the diameter of the alveoli is decreased
• a thickening and increase in the number of septa separating the alveoli are seen





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory