mortality/aging
• homozygotes die immediately after birth
|
• 4 of 27 embryos are dead at E13.5
|
respiratory system
• seen at birth
|
• alveoli are unexpanded possibly a result of pulmonary edema
|
cardiovascular system
• vascular patterning appears normal; however, at E13.5 vascular endothelial cells that are abnormally electron light are seen
|
• more immature endocardial cells are seen compared to wild-type mice
|
small heart
(
J:26844
)
• the heart is small at birth but appears grossly morphologically normal at E13.5
|
hemorrhage
(
J:26844
)
• at E13.5 subcutaneous hemorrhage is seen on the back of dead embryos (4 of 27)
• at birth, hemorrhages are seen in the tail tip, and in some mice in the toe tips and sagital sinus of the head and back, also internal hemorrhages are also seen in many organs including the intestine and stomach
• erythrocytes extravasate through the endothelial cells not through the tight junctions between these cells
|
homeostasis/metabolism
• seen at birth
|
• seen at birth
|
skin edema
(
J:26844
)
• subcutaneous edema of the back is seen at E13.5 in living embryos and at birth
|
digestive/alimentary system
• seen at birth
|
integument
skin edema
(
J:26844
)
• subcutaneous edema of the back is seen at E13.5 in living embryos and at birth
|