About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Casp4tm1Yuan
targeted mutation 1, Junying Yuan
MGI:2159366
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Casp4tm1Yuan/Casp4tm1Yuan B6.129S4(D2)-Casp4tm1Yuan/J MGI:6358247
hm2
 		Casp4tm1Yuan/Casp4tm1Yuan involves: 129S4/SvJae * C57BL/6J * DBA/2 MGI:2659134


Genotype
MGI:6358247
hm1
Allelic
Composition		 Casp4tm1Yuan/Casp4tm1Yuan
Genetic
Background		 B6.129S4(D2)-Casp4tm1Yuan/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp4tm1Yuan mutation (1 available); any Casp4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:270123 )
• bone marrow derived macrophages primed with Pam3CSK4 and transfected with LPS do not show induction of IL-1beta secretion
decreased interleukin-18 secretion ( J:270123 )
• bone marrow derived macrophages primed with Pam3CSK4 and transfected with LPS do not show induction of IL-18 secretion




Genotype
MGI:2659134
hm2
Allelic
Composition		 Casp4tm1Yuan/Casp4tm1Yuan
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp4tm1Yuan mutation (1 available); any Casp4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating interleukin-1 alpha level ( J:46167 )
• decreased levels of serum IL-1alpha after lipopolysaccharide stimulation
decreased circulating interleukin-1 beta level ( J:46167 )
• decreased levels of serum IL-1beta after lipopolysaccharide stimulation
decreased susceptibility to endotoxin shock ( J:46167 )
• resistance to septic shock following LPS injection

homeostasis/metabolism
decreased circulating interleukin-1 alpha level ( J:46167 )
• decreased levels of serum IL-1alpha after lipopolysaccharide stimulation
decreased circulating interleukin-1 beta level ( J:46167 )
• decreased levels of serum IL-1beta after lipopolysaccharide stimulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory