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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Casp4tm1Yuan
targeted mutation 1, Junying Yuan
MGI:2159366
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Casp4tm1Yuan/Casp4tm1Yuan B6.129S4(D2)-Casp4tm1Yuan/J MGI:6358247
hm2
 		Casp4tm1Yuan/Casp4tm1Yuan involves: 129S4/SvJae * C57BL/6J * DBA/2 MGI:2659134


Genotype
MGI:6358247
hm1
Allelic
Composition		 Casp4tm1Yuan/Casp4tm1Yuan
Genetic
Background		 B6.129S4(D2)-Casp4tm1Yuan/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp4tm1Yuan mutation (1 available); any Casp4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-1 beta secretion ( J:270123 )
• bone marrow derived macrophages primed with Pam3CSK4 and transfected with LPS do not show induction of IL-1beta secretion
decreased interleukin-18 secretion ( J:270123 )
• bone marrow derived macrophages primed with Pam3CSK4 and transfected with LPS do not show induction of IL-18 secretion




Genotype
MGI:2659134
hm2
Allelic
Composition		 Casp4tm1Yuan/Casp4tm1Yuan
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp4tm1Yuan mutation (1 available); any Casp4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating interleukin-1 alpha level ( J:46167 )
• decreased levels of serum IL-1alpha after lipopolysaccharide stimulation
decreased circulating interleukin-1 beta level ( J:46167 )
• decreased levels of serum IL-1beta after lipopolysaccharide stimulation
decreased susceptibility to endotoxin shock ( J:46167 )
• resistance to septic shock following LPS injection

homeostasis/metabolism
decreased circulating interleukin-1 alpha level ( J:46167 )
• decreased levels of serum IL-1alpha after lipopolysaccharide stimulation
decreased circulating interleukin-1 beta level ( J:46167 )
• decreased levels of serum IL-1beta after lipopolysaccharide stimulation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory