Analysis Tools
cellular
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• increase in numbers of germ cells in the ovaries due to reduced apoptosis
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• increase in the number of oocytes due to reduced apoptosis in the female germline
• oocytes exhibit almost complete resistance to apoptosis induced by the chemotherapeutic drug doxorubicin
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• reduction in apoptosis of female germ cells and oocytes exhibit almost complete resistance to apoptosis induced by the chemotherapeutic drug doxorubicin
• programmed cell death of facial motor neurons is accelerated during development
• B lymphoblasts are more resistant to apoptosis induced by granzyme B and perforin than wild-type cells
• slight increase in apoptosis of sympathetic neurons from the superior cervical ganglia following deprivation of nerve growth factor
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• B lymphoblasts are more resistant to apoptosis induced by granzyme B and perforin than wild-type cells
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• programmed cell death of facial motor neurons is accelerated during development
• slight increase in apoptosis of sympathetic neurons from the superior cervical ganglia following deprivation of nerve growth factor
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reproductive system
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• increase in numbers of germ cells in the ovaries due to reduced apoptosis
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• increase in the number of oocytes due to reduced apoptosis in the female germline
• oocytes exhibit almost complete resistance to apoptosis induced by the chemotherapeutic drug doxorubicin
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• increase in the number of primordial follicles in the postnatal ovary
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nervous system
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• programmed cell death of facial motor neurons is accelerated during development
• slight increase in apoptosis of sympathetic neurons from the superior cervical ganglia following deprivation of nerve growth factor
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• slight increase in apoptosis of sympathetic neurons from the superior cervical ganglia following deprivation of nerve growth factor
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• number of motor neurons in the facial nuclei of late embryonic and newborn mutants is only 73% of that in wild-type, however, normal numbers are seen at E16.5 and at P7-P9, suggesting that programmed cell death of facial motor neurons is accelerated during development but eventually similar numbers of neurons die
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endocrine/exocrine glands
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• increase in the number of primordial follicles in the postnatal ovary
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immune system
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• B lymphoblasts are more resistant to apoptosis induced by granzyme B and perforin than wild-type cells
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hematopoietic system
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• B lymphoblasts are more resistant to apoptosis induced by granzyme B and perforin than wild-type cells
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