Phenotypes associated with this allele

• Allele Symbol: Casp8^tm1Yuan
• Allele Name: targeted mutation 1, Junying Yuan
• Allele ID: MGI:2159369
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Casp8^tm1Yuan/Casp8^tm1Yuan	involves: 129S1/Sv * 129X1/SvJ * MF1	MGI:3706519

Genotype
MGI:3706519

hm1

• Allelic Composition: Casp8^tm1Yuan/Casp8^tm1Yuan
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:49459 )

• some embryos are found dead or close to death at E12.5 and no homozygotes are recovered at birth

embryonic lethality, complete penetrance ( J:49459 )

• none recovered at birth

growth/size/body

decreased embryo size ( J:49459 )

• most mutants are smaller than wild-type

embryo

decreased embryo size ( J:49459 )

• most mutants are smaller than wild-type

cardiovascular system

abnormal myocardium layer morphology ( J:49459 )

• impaired heart muscle development

abnormal myocardial trabeculae morphology ( J:49459 )

• the trabeculae are thin and disorganized

thin myocardium ( J:49459 )

• the cardiac ventricular musculature is thin and in some cases not different from early mesenchyme

abnormal heart ventricle morphology ( J:49459 )

• the cardiac ventricular musculature is thin and in some cases not different from early mesenchyme

abnormal blood circulation ( J:49459 )

• hyperemia is seen at E11.5 in the abdominal area, in most major blood vessels and the superficial capillaries, mainly in the umbilical and trunk area, including those in the intersomitic and interdigital blood vessels, in the liver, lung, mesenchymal spaces, and to a lesser degree, in the retina and under the capsule of the lens

• erythrocytes are contained in larger and smaller blood vessel areas, suggesting hyperemia and/or congestion rather than outright bleeding

hematopoietic system

abnormal blood cell morphology/development ( J:49459 )

• recovery of hematopoietic colony-forming cells from embryos is very small

increased erythrocyte cell number ( J:49459 )

• extensive erythrocytosis in the liver at E10.5-13.5; most of the liver is occupied by fully formed embryonic erythrocytes

muscle

abnormal myocardium layer morphology ( J:49459 )

• impaired heart muscle development

abnormal myocardial trabeculae morphology ( J:49459 )

• the trabeculae are thin and disorganized

thin myocardium ( J:49459 )

• the cardiac ventricular musculature is thin and in some cases not different from early mesenchyme

cellular

abnormal cell death ( J:49459 )

• cultured fibroblasts are resistant to death induction by the TNF receptors, Fas/Apo1, and DR3 (Tnfrsf25) but are sensitive to death-inducing agents that act from within the cell