Phenotypes associated with this allele

• Allele Symbol: Cpb2^tm1Mng
• Allele Name: targeted mutation 1, Mariko Nagashima
• Allele ID: MGI:2159468
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpb2^tm1Mng/Cpb2^tm1Mng	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3720834

Genotype
MGI:3720834

hm1

• Allelic Composition: Cpb2^tm1Mng/Cpb2^tm1Mng
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:73713 , J:107340 )

• mice exhibit a retardation in their fibrinolysis activity relative to wild-type mice (J:73713)

• following treatment with bleomycin, coagulation and fibrinolysis system activity and is decreased relative to in wild-type mice (J:107340)

decreased lactate dehydrogenase level ( J:107340 )

• following treatment with bleomycin, levels of lactate dehydrogenase do not increase as much as in wild-type mice

abnormal chemokine level ( J:107340 )

• following treatment with bleomycin, levels of monocyte chemoattractant-1 (MCP-1) are decreased relative to in wild-type mice

abnormal tumor necrosis factor level ( J:107340 )

• following treatment with bleomycin, levels of tumor necrotic factor-alpha (TNF-alpha) are decreased relative to in wild-type mice

increased physiological sensitivity to xenobiotic ( J:107340 )

• following treatment with bleomycin, the total number of lymphocytes and neutrophils is decreased relative to in wild-type mice and mice exhibit less lung injury

• following treatment with bleomycin, levels of monocyte chemoattractant-1 (MCP-1), tumor necrotic factor-alpha (TNF-alpha), and lactate dehydrogenase are decreased

• following treatment with bleomycin, coagulation and fibrinolysis system activity is decreased relative to in wild-type mice

• following treatment with bleomycin, collagen and fibrin deposition in the lungs is reduced relative to in wild-type mice

immune system

abnormal chemokine level ( J:107340 )

• following treatment with bleomycin, levels of monocyte chemoattractant-1 (MCP-1) are decreased relative to in wild-type mice

abnormal tumor necrosis factor level ( J:107340 )

• following treatment with bleomycin, levels of tumor necrotic factor-alpha (TNF-alpha) are decreased relative to in wild-type mice

respiratory system

pulmonary fibrosis ( J:107340 )

• following treatment with bleomycin, collagen deposition in the lungs is reduced relative to in wild-type mice