Phenotypes associated with this allele

• Allele Symbol: Arfrp1^tm1Asch
• Allele Name: targeted mutation 1, A Schurmann
• Allele ID: MGI:2159671
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arfrp1^tm1Asch/Arfrp1^tm1Asch	involves: 129X1/SvJ * C57BL/6J	MGI:2183290

Genotype
MGI:2183290

hm1

• Allelic Composition: Arfrp1^tm1Asch/Arfrp1^tm1Asch
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:74645 )

• no homozygotes found in offspring of heterozygous crosses

embryo

abnormal egg cylinder morphology ( J:74645 )

• smaller in size; apoptotic cells found in distal end of cylinder

decreased egg cylinder size ( J:74645 )

absent ectoplacental cavity ( J:74645 )

absent extraembryonic coelom ( J:74645 )

• absent exocoelomic cavities

cellular

abnormal cell physiology ( J:142321 )

• E-cadherin is mistargeted to intracellular compartments, whereas in control embryos it is present at the cell surface of trophectodermal and ectodermal cells, suggesting defects in plasma membrane trafficking of adhesion proteins