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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kif5btm1Noh
targeted mutation 1, Nobutaka Hirokawa
MGI:2159694
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kif5btm1Noh/Kif5btm1Noh involves: 129S4/SvJae * C57BL/6J MGI:3583004


Genotype
MGI:3583004
hm1
Allelic
Composition		 Kif5btm1Noh/Kif5btm1Noh
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif5btm1Noh mutation (0 available); any Kif5b mutation (61 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:48447 )
• death occurred between E9.5 and E11.5 but embryos were unturned at last observation

embryo
abnormal embryo turning ( J:48447 )
• embryo turning has not occurred at E9.5
decreased embryo size ( J:48447 )
• severe growth retardation at E9.5 as determined by crown to rump lengths

cellular
abnormal mitochondrial morphology ( J:48447 )
• mitochondria clustered perinuclearly and anchored to microtubules
abnormal lysosome morphology ( J:48447 )
• tended to be more clustered than in controls

growth/size/body
decreased embryo size ( J:48447 )
• severe growth retardation at E9.5 as determined by crown to rump lengths




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory