Phenotypes associated with this allele

• Allele Symbol: Tacc3^tm1Jni
• Allele Name: targeted mutation 1, James N Ihle
• Allele ID: MGI:2159700
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tacc3^tm1Jni/Tacc3^tm1Jni	involves: 129P2/OlaHsd * C57BL/6	MGI:3036150

Genotype
MGI:3036150

hm1

• Allelic Composition: Tacc3^tm1Jni/Tacc3^tm1Jni
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:74762 )

• embryos die at mid to late gestation

craniofacial

midline facial cleft ( J:74762 )

• noted in 2/3 of homozygous embryos

embryo

decreased embryo size ( J:74762 )

• embryos appear smaller than controls

growth/size/body

midline facial cleft ( J:74762 )

• noted in 2/3 of homozygous embryos

decreased embryo size ( J:74762 )

• embryos appear smaller than controls

hematopoietic system

small thymus ( J:74762 )

decreased thymocyte number ( J:74762 )

• reduced number of fetal thymocytes

abnormal definitive hematopoiesis ( J:74762 )

• homozygotes also exhibit reductions in BFU-E, both in number and colony size

decreased hematopoietic stem cell number ( J:74762 )

• homozygotes exhibit a deficiency of hematopoietic stem cell colony forming activity; the frequency of these cells is 1-5% of controls

immune system

small thymus ( J:74762 )

decreased thymocyte number ( J:74762 )

• reduced number of fetal thymocytes

liver/biliary system

liver hypoplasia ( J:74762 )

• reduced number of fetal liver cells; total number of fetal liver cells was 1/2 to 1/4 of controls

endocrine/exocrine glands

small thymus ( J:74762 )

decreased thymocyte number ( J:74762 )

• reduced number of fetal thymocytes