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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pik3r2tm1Lca
targeted mutation 1, Lewis C Cantley
MGI:2159732
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pik3r2tm1Lca/Pik3r2tm1Lca involves: 129S6/SvEvTac MGI:3042803
cn2
 		Krastm4Tyj/Kras+
Pik3r1tm1Lca/Pik3r1tm1Lca
Pik3r2tm1Lca/Pik3r2tm1Lca 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:3834443
cn3
 		Krastm4Tyj/Kras+
Pik3r2tm1Lca/Pik3r2tm1Lca 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:3834444
cn4
 		Krastm4Tyj/Kras+
Pik3r1tm1Lca/Pik3r1+
Pik3r2tm1Lca/Pik3r2tm1Lca 		involves: 129S4/SvJae * 129S6/SvEvTac MGI:3834445
cn5
 		Pik3r1tm1Lca/Pik3r1tm1Lca
Pik3r2tm1Lca/Pik3r2tm1Lca
Tg(Ckmm-cre)5Khn/0 		involves: 129S6/SvEvTac * C57BL/6 * FVB MGI:3609012


Genotype
MGI:3042803
hm1
Allelic
Composition		 Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r2tm1Lca mutation (1 available); any Pik3r2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating glucose level ( J:73703 )
• lower glucose levels both in the fed state and in the fasting state
decreased circulating insulin level ( J:73703 )
• significantly lower levels in the fed state and tending to lower levels in the fasting state
increased insulin sensitivity ( J:73703 )
• improved insulin sensitivity




Genotype
MGI:3834443
cn2
Allelic
Composition		 Krastm4Tyj/Kras+
Pik3r1tm1Lca/Pik3r1tm1Lca
Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Pik3r2tm1Lca mutation (1 available); any Pik3r2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre, mice develop fewer lung tumors than in Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca or Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca Pik3r1tm1Lca/Pik3r1+ mice

respiratory system
decreased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre, mice develop fewer lung tumors than in Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca or Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca Pik3r1tm1Lca/Pik3r1+ mice




Genotype
MGI:3834444
cn3
Allelic
Composition		 Krastm4Tyj/Kras+
Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Pik3r2tm1Lca mutation (1 available); any Pik3r2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre

respiratory system
increased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre




Genotype
MGI:3834445
cn4
Allelic
Composition		 Krastm4Tyj/Kras+
Pik3r1tm1Lca/Pik3r1+
Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Pik3r2tm1Lca mutation (1 available); any Pik3r2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre

respiratory system
increased lung tumor incidence ( J:142254 )
• following administration of inhaled adenovirus cre




Genotype
MGI:3609012
cn5
Allelic
Composition		 Pik3r1tm1Lca/Pik3r1tm1Lca
Pik3r2tm1Lca/Pik3r2tm1Lca
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Lca mutation (1 available); any Pik3r1 mutation (56 available)
Pik3r2tm1Lca mutation (1 available); any Pik3r2 mutation (38 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased myocardial fiber size ( J:102176 )
• most cardiomyocytes are reduced in size
decreased heart weight ( J:102176 )
• heart size normalized to body weight or tibia length is about 20% smaller than in wild-type mice; however the structure of the heart is normal with no obvious signs of fibrosis or tissue damage
• the increase in heart size in response to exercise is decreased compared to wild-type mice

muscle
decreased myocardial fiber size ( J:102176 )
• most cardiomyocytes are reduced in size




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory