All Phenotypes Irf2<tm1Mak> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irf2^tm1Mak/Irf2^tm1Mak	either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J * DBA/2)	MGI:2180214
hm2	Irf2^tm1Mak/Irf2^tm1Mak	involves: 129S2/SvPas * C57BL/6	MGI:3630266
ht3	Irf2^tm1Mak/Irf2⁺	either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J * DBA/2)	MGI:3769112
cx4	B2m^tm1Unc/B2m^tm1Unc Irf2^tm1Mak/Irf2^tm1Mak	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3630269
cx5	Cd4^tm1Mak/Cd4^tm1Mak Irf2^tm1Mak/Irf2^tm1Mak	involves: 129S2/SvPas * C57BL/6	MGI:3630270
cx6	Ighm^tm1Cgn/Ighm^tm1Cgn Irf2^tm1Mak/Irf2^tm1Mak	involves: 129S2/SvPas * C57BL/6	MGI:3630271
cx7	Ifnar1^tm1Agt/Ifnar1^tm1Agt Irf2^tm1Mak/Irf2^tm1Mak	involves: 129S2/SvPas * C57BL/6	MGI:3630272
cx8	Cd8a^tm1Mak/Cd8a^tm1Mak Irf2^tm1Mak/Irf2^tm1Mak	involves: 129S2/SvPas * C57BL/6	MGI:3630273
cx9	Irf2^tm1Mak/Irf2^tm1Mak Irf9^tm1Ttg/Irf9^tm1Ttg	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:3630268
cx10	Irf2^tm1Mak/Irf2^tm1Mak Psds1^C57BL/6/Psds1^C57BL/6 Psds3^BALB/c/Psds3^C57BL/6	involves: BALB/c * C57BL/6	MGI:3759802

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:64286 )

• ~38% of mice die within 8 months of birth, compared to 12% of wild-type mice; females often die after giving birth

• despite normal CTL activity toward LCMV infection, and virus clearance, mice die or are moribund within 4 weeks of infection, compared to infected wild-type or Irf1-deficient mice or uninfected controls which remain healthy more than 1 month after infection

immune system

immune system phenotype ( J:64286 )

• mice have normal numbers of CD8+ T lymphocytes in peripheral blood, lymph node, and spleen

• in response to LCMV infection, mice show normal CTL (cytotoxic T lymphocyte) activity and virus is cleared by 15 days after infection

• humoral response to vesicular stomatitis virus challenge is normal; kinetics of immunoglobulin class switching and antibody levels are comparable to wild-type mice

decreased mature B cell number ( J:64286 )

• bone marrow contains only 30-70% of wild-type number of mature B cells (B220^high/surface IgM (sIgM)-positive cells)

decreased T cell number ( J:64286 )

• in bone marrow, number of Thy-1-positive T cells is reduced to 20-50% of wild-type and heterozygous mice; these are considered to be mature TCR alpha-beta positive T cells

abnormal immune system physiology ( J:64286 )

• some nonspecific cytotoxicity is detected

decreased B cell proliferation ( J:64286 )

• bone marrow cells show a dramatic decrease in colony formation in vitro (70% reduction compared to wild-type cells) in response to LPS, a B cell mitogen; splenocytes show a 30% reduction in colony formation in response to LPS

• reduced colony formation (by 40%) by bone marrow cells is seen in response to Il3, Il7 and CSF1 indicating that responses of multipotential progenitors, pre-B cells and macrophages in bone marrow are altered

decreased IgG2a level ( J:64286 )

• serum IgG2a levels are significantly reduced

abnormal response to infection ( J:64286 )

hematopoietic system

decreased B cell proliferation ( J:64286 )

decreased mature B cell number ( J:64286 )

• bone marrow contains only 30-70% of wild-type number of mature B cells (B220^high/surface IgM (sIgM)-positive cells)

decreased T cell number ( J:64286 )

• in bone marrow, number of Thy-1-positive T cells is reduced to 20-50% of wild-type and heterozygous mice; these are considered to be mature TCR alpha-beta positive T cells

decreased IgG2a level ( J:64286 )

• serum IgG2a levels are significantly reduced

integument

skin lesions ( J:64286 )

• older animals exhibit erosions and ulcers around the neck, back and abdomen; in severe cases, patchy scars and postinflammatory hair loss can result

cellular

decreased B cell proliferation ( J:64286 )

Allelic Composition	Irf2^tm1Mak/Irf2^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf2^tm1Mak mutation (1 available); any Irf2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased memory T cell number ( J:66034 )

• activated/memory CD8+ T cells become more prominent in the spleen after 3 months and after 5 months their percentage exceeds 80%

lymph node hyperplasia ( J:66034 )

• inguinal lymph nodes have 3 times the number of cells as do wild-type and heterozygous littermates as the disease progresses

enlarged inguinal lymph nodes ( J:66034 )

• as skin diseases advances, draining lymph nodes become enlarged

dermatitis ( J:66034 )

• signs of progressive cutaneous inflammation begin as early as 8 weeks of age

hematopoietic system

increased memory T cell number ( J:66034 )

• activated/memory CD8+ T cells become more prominent in the spleen after 3 months and after 5 months their percentage exceeds 80%

integument

dermatitis ( J:66034 )

• signs of progressive cutaneous inflammation begin as early as 8 weeks of age

premature hair loss ( J:66034 )

• hair loss begins as early as 8 weeks of age and eventually extends over the entire trunk

thick epidermis ( J:66034 )

• thickening of the epidermis results from proliferation of keratinocytes in the basal epidermis

reddish skin ( J:66034 )

• homozygotes develop erythema as early as 8 weeks of age

skin lesions ( J:66034 )

• skin lesions occur, and excoriation of lesions results in ulcer formation eventually

skin fibrosis ( J:66034 )

• below the epidermis disorganization of the muscle layer and associated prominent fibrosis is seen

Allelic Composition	Irf2^tm1Mak/Irf2⁺
Genetic Background	either: (involves: 129S2/SvPas * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J * DBA/2)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf2^tm1Mak mutation (1 available); any Irf2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:64286 )

• mice are viable and fertile, with no detectable abnormalities

Allelic Composition	B2m^tm1Unc/B2m^tm1Unc Irf2^tm1Mak/Irf2^tm1Mak
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2m^tm1Unc mutation (38 available); any B2m mutation (122 available)
Irf2^tm1Mak mutation (1 available); any Irf2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin condition ( J:66034 )

• no skin symptoms are observed up to 4 months of age compared to Irf2-null mice

Allelic Composition	Cd4^tm1Mak/Cd4^tm1Mak Irf2^tm1Mak/Irf2^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4^tm1Mak mutation (5 available); any Cd4 mutation (85 available)
Irf2^tm1Mak mutation (1 available); any Irf2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin condition ( J:66034 )

• mice develop similar skin symptoms to Irf2-null mice

Allelic Composition	Ighm^tm1Cgn/Ighm^tm1Cgn Irf2^tm1Mak/Irf2^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighm^tm1Cgn mutation (17 available); any Ighm mutation (56 available)
Irf2^tm1Mak mutation (1 available); any Irf2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin condition ( J:66034 )

• mice develop similar skin symptoms to Irf2-null mice

Allelic Composition	Ifnar1^tm1Agt/Ifnar1^tm1Agt Irf2^tm1Mak/Irf2^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnar1^tm1Agt mutation (11 available); any Ifnar1 mutation (60 available)
Irf2^tm1Mak mutation (1 available); any Irf2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin condition ( J:66034 )

• no skin symptoms are observed up to 4 months of age compared to Irf2-null mice

Allelic Composition	Cd8a^tm1Mak/Cd8a^tm1Mak Irf2^tm1Mak/Irf2^tm1Mak
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8a^tm1Mak mutation (7 available); any Cd8a mutation (39 available)
Irf2^tm1Mak mutation (1 available); any Irf2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin condition ( J:66034 )

• no skin symptoms are observed up to 4 months of age compared to Irf2-null mice

Allelic Composition	Irf2^tm1Mak/Irf2^tm1Mak Irf9^tm1Ttg/Irf9^tm1Ttg
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf2^tm1Mak mutation (1 available); any Irf2 mutation (24 available)
Irf9^tm1Ttg mutation (2 available); any Irf9 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin condition ( J:66034 )

• no skin symptoms are observed up to 4 months of age compared to Irf2-null mice

Allelic Composition	Irf2^tm1Mak/Irf2^tm1Mak Psds1^C57BL/6/Psds1^C57BL/6 Psds3^BALB/c/Psds3^C57BL/6
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf2^tm1Mak mutation (1 available); any Irf2 mutation (24 available)
Psds1^C57BL/6 mutation (0 available); any Psds1 mutation (0 available)
Psds3^BALB/c mutation (0 available); any Psds3 mutation (0 available)
Psds3^C57BL/6 mutation (0 available); any Psds3 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

psoriasis ( J:125685 )

• significantly increased skin disease severity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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