Phenotypes associated with this allele

• Allele Symbol: Il15ra^tm1.1Nsl
• Allele Name: targeted mutation 1.1, Nan-Shih Liao
• Allele ID: MGI:2176074
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il15ra^tm1.1Nsl/Il15ra^tm1.1Nsl	B6.129X1-Il15ra^tm1.1Nsl	MGI:3845656
hm2	Il15ra^tm1.1Nsl/Il15ra^tm1.1Nsl	involves: 129X1/SvJ * C57BL/6	MGI:3845543
cx3	Il15ra^tm1.1Nsl/Il15ra^tm1.1Nsl Tg(TcrAND)53Hed/?	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:3845657

Genotype
MGI:3845656

hm1

• Allelic Composition: Il15ra^tm1.1Nsl/Il15ra^tm1.1Nsl
• Genetic Background: B6.129X1-Il15ra^tm1.1Nsl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell activation ( J:92705 )

• upon TCR stimulation, CD4⁺ T cells have increased activation of the calcineurin pathway, the Ras-ERK pathway, and the Rac/vav-JNK pathway

abnormal T cell proliferation ( J:92705 )

• CD4⁺ T cells are hyperresponsive to in vitro TCR stimulation while CD8⁺ T cells are hyporesponsive

increased T cell proliferation ( J:92705 )

• CD4⁺ T cells are hyperresponsive to in vitro TCR stimulation

• these T cells divided more vigorously than wild-type cells in response to low, optimal, and high doses of anti-TCR mAb stimulation

• CD4⁺ T cells also proliferate more strongly in vivo to the super antigen staphylococcal enterotoxin B or upon second encounter with keyhole limpet hemocyanin

increased interleukin-2 secretion ( J:92705 )

• IL-2 production by activated CD4⁺ T cells is enhanced in these mice

hematopoietic system

abnormal T cell activation ( J:92705 )

• upon TCR stimulation, CD4⁺ T cells have increased activation of the calcineurin pathway, the Ras-ERK pathway, and the Rac/vav-JNK pathway

abnormal T cell proliferation ( J:92705 )

• CD4⁺ T cells are hyperresponsive to in vitro TCR stimulation while CD8⁺ T cells are hyporesponsive

increased T cell proliferation ( J:92705 )

• CD4⁺ T cells are hyperresponsive to in vitro TCR stimulation

• these T cells divided more vigorously than wild-type cells in response to low, optimal, and high doses of anti-TCR mAb stimulation

• CD4⁺ T cells also proliferate more strongly in vivo to the super antigen staphylococcal enterotoxin B or upon second encounter with keyhole limpet hemocyanin

cellular

abnormal T cell proliferation ( J:92705 )

• CD4⁺ T cells are hyperresponsive to in vitro TCR stimulation while CD8⁺ T cells are hyporesponsive

increased T cell proliferation ( J:92705 )

• CD4⁺ T cells are hyperresponsive to in vitro TCR stimulation

• these T cells divided more vigorously than wild-type cells in response to low, optimal, and high doses of anti-TCR mAb stimulation

• CD4⁺ T cells also proliferate more strongly in vivo to the super antigen staphylococcal enterotoxin B or upon second encounter with keyhole limpet hemocyanin

Genotype
MGI:3845543

hm2

• Allelic Composition: Il15ra^tm1.1Nsl/Il15ra^tm1.1Nsl
• Genetic Background: involves: 129X1/SvJ * C57BL/6

immune system

abnormal T cell apoptosis ( J:73738 )

• CD44^hi CD8⁺ memory T cells have increased rates of apoptosis in vivo and in the first 24 hours of culture

• CD8⁺ T cells stimulated in vitro have higher rates of apoptosis than controls

• increased rates of apoptosis are associated with decreased amounts of Bcl-2 protein

increased thymocyte apoptosis ( J:73738 )

• CD8 single-positive thymoyctes have increased rates of apoptosis compared to controls when cultured without growth factors

decreased NK cell number ( J:73738 )

• NK cell numbers are greatly decreased

increased CD4-positive, alpha-beta T cell number ( J:73738 )

• the percentage of CD4 T cells is 20% higher than controls in the spleen and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:73738 )

• the percentage of CD8 T cells is half that of controls in the spleen and lymph nodes

decreased NK T cell number ( J:73738 )

• NK T cell numbers are greatly decreased

decreased memory T cell number ( J:73738 )

• CD44^hi CD8⁺ memory T cells are decreased 72% compared to controls

decreased single-positive T cell number ( J:73738 )

• the TCR^hiCD8 single-positive thymocyte population is reduced by 20%

lymph node hypoplasia ( J:73738 )

• lymph nodes have 30% fewer cells than controls

hematopoietic system

abnormal T cell apoptosis ( J:73738 )

• CD44^hi CD8⁺ memory T cells have increased rates of apoptosis in vivo and in the first 24 hours of culture

• CD8⁺ T cells stimulated in vitro have higher rates of apoptosis than controls

• increased rates of apoptosis are associated with decreased amounts of Bcl-2 protein

increased thymocyte apoptosis ( J:73738 )

• CD8 single-positive thymoyctes have increased rates of apoptosis compared to controls when cultured without growth factors

decreased NK cell number ( J:73738 )

• NK cell numbers are greatly decreased

increased CD4-positive, alpha-beta T cell number ( J:73738 )

• the percentage of CD4 T cells is 20% higher than controls in the spleen and lymph nodes

decreased CD8-positive, alpha-beta T cell number ( J:73738 )

• the percentage of CD8 T cells is half that of controls in the spleen and lymph nodes

decreased NK T cell number ( J:73738 )

• NK T cell numbers are greatly decreased

decreased memory T cell number ( J:73738 )

• CD44^hi CD8⁺ memory T cells are decreased 72% compared to controls

decreased single-positive T cell number ( J:73738 )

• the TCR^hiCD8 single-positive thymocyte population is reduced by 20%

cellular

abnormal T cell apoptosis ( J:73738 )

• CD44^hi CD8⁺ memory T cells have increased rates of apoptosis in vivo and in the first 24 hours of culture

• CD8⁺ T cells stimulated in vitro have higher rates of apoptosis than controls

• increased rates of apoptosis are associated with decreased amounts of Bcl-2 protein

increased thymocyte apoptosis ( J:73738 )

• CD8 single-positive thymoyctes have increased rates of apoptosis compared to controls when cultured without growth factors

endocrine/exocrine glands

increased thymocyte apoptosis ( J:73738 )

• CD8 single-positive thymoyctes have increased rates of apoptosis compared to controls when cultured without growth factors

Genotype
MGI:3845657

cx3

• Allelic Composition: Il15ra^tm1.1Nsl/Il15ra^tm1.1Nsl; Tg(TcrAND)53Hed/?
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

immune system

increased T cell proliferation ( J:92705 )

• the activation threshold for transgenic CD4⁺ T cells is much lower than wild-type transgenic T cells

• both weak and strong peptide agonists caused increased amounts of proliferation compared to controls

hematopoietic system

increased T cell proliferation ( J:92705 )

• the activation threshold for transgenic CD4⁺ T cells is much lower than wild-type transgenic T cells

• both weak and strong peptide agonists caused increased amounts of proliferation compared to controls

cellular

increased T cell proliferation ( J:92705 )

• the activation threshold for transgenic CD4⁺ T cells is much lower than wild-type transgenic T cells

• both weak and strong peptide agonists caused increased amounts of proliferation compared to controls