All Phenotypes Tg(MMTV-cre)1Mam MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(MMTV-cre)1Mam
transgene insertion 1, Lothar Hennighausen
MGI:2176165

Summary

24 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ccn6^tm1.1Cgkl/Ccn6^tm1.1Cgkl Tg(MMTV-cre)1Mam/0	FVB/N-Ccn6^tm1.1Cgkl Tg(MMTV-cre)1Mam	MGI:6093470
cn2	Ccn6^tm1.1Cgkl/Ccn6^tm1.1Cgkl Tg(MMTV-cre)1Mam/0 Tg(MMTV-PyVT)634Mul/0	FVB/N-Ccn6^tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul	MGI:6093471
cn3	Rev3l^tm1Rwd/Rev3l^tm2.1Rwd Trp53^tm1Brd/Trp53^tm1Brd Tg(MMTV-cre)1Mam/0	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:4441274
cn4	Rev3l^tm1Rwd/Rev3l^tm2.1Rwd Trp53^tm1Brd/Trp53⁺ Tg(MMTV-cre)1Mam/0	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:4441276
cn5	Rev3l^tm1Rwd/Rev3l^tm2.1Rwd Tg(MMTV-cre)1Mam/0	involves: 129P2/OlaHsd * C57BL/6 * FVB	MGI:4441273
cn6	Rbpj^tm1Hon/Rbpj^tm1Hon Tg(MMTV-cre)1Mam/0	involves: 129P2/OlaHsd * C57BL/6J * FVB * SJL	MGI:3653205
cn7	Kdm4b^tm1.1Okad/Kdm4b^tm1.1Okad Tg(MMTV-cre)1Mam/0	involves: 129P2/OlaHsd * FVB	MGI:4999589
cn8	Pofut1^tm2Pst/Pofut1^tm2Pst Tg(MMTV-cre)1Mam/0	involves: 129P2/OlaHsd * FVB	MGI:3653206
cn9	Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Tg(MMTV-cre)1Mam/0	involves: 129S1/Sv * 129X1/SvJ * CD-1 * FVB	MGI:4418467
cn10	Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0 Tg(MMTV-rtTA)1Lach/0 Tg(tetO-Stat5a)#Mam/0	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:4847638
cn11	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0 Tg(MMTV-rtTA)1Lach/0 Tg(tetO-Stat5a)#Mam/0	involves: 129S6/SvEvTac * C57BL/6J * FVB/N	MGI:4847637
cn12	Gt(ROSA)26Sor^{tm2(Pik3ca)Egan}/Gt(ROSA)26Sor⁺ Tg(MMTV-cre)1Mam/0	involves: 129S6/SvEvTac * FVB/N	MGI:5000481
cn13	Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺ Tg(MMTV-cre)1Mam/0	involves: 129S6/SvEvTac * FVB/N	MGI:5000476
cn14	Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0	involves: 129S6/SvEvTac * FVB/N	MGI:4847556
cn15	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0	involves: 129S6/SvEvTac * FVB/N	MGI:4847555
cn16	Jak2^tm1Kuw/Jak2^tm1Kuw Tg(MMTV-cre)1Mam/0	involves: 129X1/SvJ * C57BL/6 * FVB	MGI:3045399
cn17	Pparg^tm1Gonz/Pparg^tm1Gonz Tg(MMTV-cre)1Mam/?	involves: 129X1/SvJ * FVB	MGI:3722293
cn18	Arnt^tm1Gonz/Arnt^tm1Gonz Tg(MMTV-cre)1Mam/0	involves: 129X1/SvJ * FVB	MGI:3656140
cn19	Jak1^tm1Kuw/Jak1^tm1Kuw Tg(MMTV-cre)1Mam/0	involves: 129X1/SvJ * FVB	MGI:5796282
cn20	Id4^tm1Vdr/Id4⁺ Tg(MMTV-cre)1Mam/0	involves: C57BL/6 * FVB/N	MGI:5805280
cn21	Id4^tm1Vdr/Id4^tm1Vdr Tg(MMTV-cre)1Mam/0	involves: C57BL/6 * FVB/N	MGI:5805279
cn22	Pik3ca^tm1Gne/Pik3ca⁺ Tg(MMTV-cre)1Mam/0	involves: C57BL/6N * FVB/N	MGI:5469591
cn23	Becn1^tm1Ebr/Becn1⁺ Tg(MMTV-cre)1Mam/?	involves: FVB	MGI:5308737
tg24	Tg(MMTV-cre)1Mam/?	involves: FVB	MGI:4888636

Allelic Composition	Ccn6^tm1.1Cgkl/Ccn6^tm1.1Cgkl Tg(MMTV-cre)1Mam/0
Genetic Background	FVB/N-Ccn6^tm1.1Cgkl Tg(MMTV-cre)1Mam

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccn6^tm1.1Cgkl mutation (0 available); any Ccn6 mutation (23 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:241259 )

• 16 week old adult virgin mice show a reduction in mammary gland complexity

• mammary glands exhibit reduced mitosis

• the non-neoplastic mammary gland tissues show a variety of abnormalities including persistent terminal end buds, secretory hyperplasia, and atypical ductal hyperplasia

abnormal involution of the mammary gland ( J:241259 )

• abnormal age-related involution in virgin mice, with all mice at 8 months of age showing residual brown adipose tissue in the mammary glands and terminal end buds that persist in 66.7% of these mice

• however, dams are able to nurse litters and glands undergo post-lactational involution

abnormal mammary gland duct morphology ( J:241259 )

• hypoplastic ductal epithelium with reduced ductal thickness in 16 week old virgin mice

• ductal epithelial cells are flat instead of tall columnar

abnormal mammary duct terminal end bud morphology ( J:241259 )

• pre-pubertal (5 week) and pubertal (8 week) mice exhibit reduced numbers of terminal end buds and of bifurcated terminal end buds

• persistent terminal end buds are seen in the non-neoplastic mammary gland tissues

mammary gland duct hyperplasia ( J:241259 )

• atypical ductal hyperplasia is seen in the non-neoplastic mammary gland tissues

increased mammary adenocarcinoma incidence ( J:241259 )

• 72.2% of mice develop mammary carcinomas between 10 and 21 months of age, with a mean age of 15.5 months

• mammary carcinomas exhibit mitotically active elongated cells of high histological grade, similar to the spindle subtype of human metaplastic carcinomas

• tumors are highly invasive into the surrounding mammary tissues and skeletal muscle

integument

abnormal mammary gland morphology ( J:241259 )

• 16 week old adult virgin mice show a reduction in mammary gland complexity

• mammary glands exhibit reduced mitosis

• the non-neoplastic mammary gland tissues show a variety of abnormalities including persistent terminal end buds, secretory hyperplasia, and atypical ductal hyperplasia

abnormal involution of the mammary gland ( J:241259 )

• however, dams are able to nurse litters and glands undergo post-lactational involution

abnormal mammary gland duct morphology ( J:241259 )

• hypoplastic ductal epithelium with reduced ductal thickness in 16 week old virgin mice

• ductal epithelial cells are flat instead of tall columnar

abnormal mammary duct terminal end bud morphology ( J:241259 )

• pre-pubertal (5 week) and pubertal (8 week) mice exhibit reduced numbers of terminal end buds and of bifurcated terminal end buds

• persistent terminal end buds are seen in the non-neoplastic mammary gland tissues

mammary gland duct hyperplasia ( J:241259 )

• atypical ductal hyperplasia is seen in the non-neoplastic mammary gland tissues

increased mammary adenocarcinoma incidence ( J:241259 )

• 72.2% of mice develop mammary carcinomas between 10 and 21 months of age, with a mean age of 15.5 months

• mammary carcinomas exhibit mitotically active elongated cells of high histological grade, similar to the spindle subtype of human metaplastic carcinomas

• tumors are highly invasive into the surrounding mammary tissues and skeletal muscle

neoplasm

increased mammary adenocarcinoma incidence ( J:241259 )

• 72.2% of mice develop mammary carcinomas between 10 and 21 months of age, with a mean age of 15.5 months

• mammary carcinomas exhibit mitotically active elongated cells of high histological grade, similar to the spindle subtype of human metaplastic carcinomas

• tumors are highly invasive into the surrounding mammary tissues and skeletal muscle

increased metastatic potential ( J:241259 )

• distant metastasis develop in 46.2% of tumor-bearing mice, mainly to the lungs and in once case the soft tissues of the neck

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast metaplastic carcinoma		DOID:4680		J:241259

Allelic Composition	Ccn6^tm1.1Cgkl/Ccn6^tm1.1Cgkl Tg(MMTV-cre)1Mam/0 Tg(MMTV-PyVT)634Mul/0
Genetic Background	FVB/N-Ccn6^tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccn6^tm1.1Cgkl mutation (0 available); any Ccn6 mutation (23 available)
Tg(MMTV-cre)1Mam mutation (1 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:241259 )

• mice develop mammary tumors with no differences in primary tumor volume from control mice expressing Tg(MMTV-PyVT)654Mul and Tg(MMTV-cre)1Mam

integument

increased mammary adenocarcinoma incidence ( J:241259 )

• mice develop mammary tumors with no differences in primary tumor volume from control mice expressing Tg(MMTV-PyVT)654Mul and Tg(MMTV-cre)1Mam

neoplasm

increased mammary adenocarcinoma incidence ( J:241259 )

• mice develop mammary tumors with no differences in primary tumor volume from control mice expressing Tg(MMTV-PyVT)654Mul and Tg(MMTV-cre)1Mam

increased metastatic potential ( J:241259 )

• female virgin mice show an increase in the number of lung metastasis compared to control mice expressing Tg(MMTV-PyVT)654Mul and Tg(MMTV-cre)1Mam

Allelic Composition	Rev3l^tm1Rwd/Rev3l^tm2.1Rwd Trp53^tm1Brd/Trp53^tm1Brd Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rev3l^tm1Rwd mutation (0 available); any Rev3l mutation (120 available)
Rev3l^tm2.1Rwd mutation (2 available); any Rev3l mutation (120 available)
Tg(MMTV-cre)1Mam mutation (1 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:158922 )

• mean survival is 91 days compared with 134 to 117 days for Trp53^tm1Brd homozygous control mice

neoplasm

increased T cell derived lymphoma incidence ( J:158922 )

• in all mice develop thymic lymphomas compared with 70% to 77% of Trp53^tm1Brd homozygous control mice

• tumors are frequently oligoclonal

• incidence of thymic lymphomas is increased while latency to development of tumors is decreased compared with Trp53^tm1Brd homozygous control mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:158922 )

• in all mice develop thymic lymphomas compared with 70% to 77% of Trp53^tm1Brd homozygous control mice

• tumors are frequently oligoclonal

• incidence of thymic lymphomas is increased while latency to development of tumors is decreased compared with Trp53^tm1Brd homozygous control mice

immune system

increased T cell derived lymphoma incidence ( J:158922 )

• in all mice develop thymic lymphomas compared with 70% to 77% of Trp53^tm1Brd homozygous control mice

• tumors are frequently oligoclonal

• incidence of thymic lymphomas is increased while latency to development of tumors is decreased compared with Trp53^tm1Brd homozygous control mice

hematopoietic system

increased T cell derived lymphoma incidence ( J:158922 )

• in all mice develop thymic lymphomas compared with 70% to 77% of Trp53^tm1Brd homozygous control mice

• tumors are frequently oligoclonal

• incidence of thymic lymphomas is increased while latency to development of tumors is decreased compared with Trp53^tm1Brd homozygous control mice

Allelic Composition	Rev3l^tm1Rwd/Rev3l^tm2.1Rwd Trp53^tm1Brd/Trp53⁺ Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:158922 )

• 11 of 36 mice develop mammary tumors consisting of solid carcinoma, carcinosarcoma, adenosquamous carcinoma, and osteosarcoma

• incidence of mammary tumors is increased while latency to development of tumors is decreased compared with Trp53^tm1Brd heterozygotes

increased carcinoma incidence ( J:158922 )

• in the mammary tissue of some mice

increased osteosarcoma incidence ( J:158922 )

• in the mammary tissue of one mouse

integument

increased mammary gland tumor incidence ( J:158922 )

• 11 of 36 mice develop mammary tumors consisting of solid carcinoma, carcinosarcoma, adenosquamous carcinoma, and osteosarcoma

• incidence of mammary tumors is increased while latency to development of tumors is decreased compared with Trp53^tm1Brd heterozygotes

skeleton

increased osteosarcoma incidence ( J:158922 )

• in the mammary tissue of one mouse

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:158922 )

• 11 of 36 mice develop mammary tumors consisting of solid carcinoma, carcinosarcoma, adenosquamous carcinoma, and osteosarcoma

• incidence of mammary tumors is increased while latency to development of tumors is decreased compared with Trp53^tm1Brd heterozygotes

Allelic Composition	Rev3l^tm1Rwd/Rev3l^tm2.1Rwd Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:158922 )

• 6 of 24 mice develop mammary tumors consisting of carcinosarcoma, solid carcinoma, and adenosquamous carcinoma

increased carcinoma incidence ( J:158922 )

• in the mammary tissue of some mice

integument

increased mammary gland tumor incidence ( J:158922 )

• 6 of 24 mice develop mammary tumors consisting of carcinosarcoma, solid carcinoma, and adenosquamous carcinoma

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:158922 )

• 6 of 24 mice develop mammary tumors consisting of carcinosarcoma, solid carcinoma, and adenosquamous carcinoma

Allelic Composition	Rbpj^tm1Hon/Rbpj^tm1Hon Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * FVB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpj^tm1Hon mutation (2 available); any Rbpj mutation (193 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:108712 )

• at day 7 of pregnancy immature alveoli consist of round cells with radially positioned nuclei around the central lumen; cells are irregularly arranged with frequent gaps between them; also many of the lumina contained cellular debris

• on day 11, epithelia appears much sparser

• on day 13, clusters of disorganized cells with irregularly- shaped nuclei are seen and lipid droplets in the lumina are rare and proteinaceous material

• at term, an increase in disorganized cell clusters is seen, with the majority of cells having dark irregularly shaped nuclei surrounding small groups of cells with larger round nuclei

• a paucity of true luminal cells is found in mutant mammary glands during pregnancy

• when mutant mammary epithelium is transplanted into athymic nude mice from which the mammary tissue had been cleared for three generations, it is seen that there is restoration of normal ductal architecture after involution

reproductive system

abnormal mammary gland growth during pregnancy ( J:108712 )

• on day 11, epithelia appears much sparser

• on day 13, clusters of disorganized cells with irregularly- shaped nuclei are seen and lipid droplets in the lumina are rare and proteinaceous material

• at term, an increase in disorganized cell clusters is seen, with the majority of cells having dark irregularly shaped nuclei surrounding small groups of cells with larger round nuclei

• a paucity of true luminal cells is found in mutant mammary glands during pregnancy

integument

abnormal mammary gland growth during pregnancy ( J:108712 )

• on day 11, epithelia appears much sparser

• on day 13, clusters of disorganized cells with irregularly- shaped nuclei are seen and lipid droplets in the lumina are rare and proteinaceous material

• at term, an increase in disorganized cell clusters is seen, with the majority of cells having dark irregularly shaped nuclei surrounding small groups of cells with larger round nuclei

• a paucity of true luminal cells is found in mutant mammary glands during pregnancy

epidermal cyst ( J:108712 )

• cysts containing abundant whorls of keratin are observed

hyperkeratosis ( J:108712 )

• mutant skin display hyperkeratinization

growth/size/body

epidermal cyst ( J:108712 )

• cysts containing abundant whorls of keratin are observed

Allelic Composition	Kdm4b^tm1.1Okad/Kdm4b^tm1.1Okad Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm4b^tm1.1Okad mutation (0 available); any Kdm4b mutation (54 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Defective mammary gland development in Kdm4b^tm1.1Okad/Kdm4b^tm1.1Okad Tg(MMTV-cre)1Mam/0 mice

integument

abnormal mammary gland development ( J:171678 )

• mammary gland development is delayed with reduced branching compared to in wild-type mice

abnormal branching of the mammary ductal tree ( J:171678 )

• mammary gland branching is reduced compared to in wild-type mice

endocrine/exocrine glands

abnormal mammary gland development ( J:171678 )

• mammary gland development is delayed with reduced branching compared to in wild-type mice

abnormal branching of the mammary ductal tree ( J:171678 )

• mammary gland branching is reduced compared to in wild-type mice

Allelic Composition	Pofut1^tm2Pst/Pofut1^tm2Pst Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129P2/OlaHsd * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pofut1^tm2Pst mutation (0 available); any Pofut1 mutation (22 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:108712 )

• in transplant experiments, development lesions with respect to disorganized alveolar morphology seen in transplanted mammary tissue are indistinguishable from those observed in Rbsuh^tm1Hon conditional mice

• epithelial compartment consists of densely packed cells with irregular dark nuclei

reproductive system

abnormal mammary gland growth during pregnancy ( J:108712 )

• epithelial compartment consists of densely packed cells with irregular dark nuclei

integument

abnormal mammary gland growth during pregnancy ( J:108712 )

• epithelial compartment consists of densely packed cells with irregular dark nuclei

epidermal cyst ( J:108712 )

• cysts containing abundant whorls of keratin are observed

hyperkeratosis ( J:108712 )

• mutant skin display hyperkeratinization

growth/size/body

epidermal cyst ( J:108712 )

• cysts containing abundant whorls of keratin are observed

Allelic Composition	Hif1a^tm3Rsjo/Hif1a^tm3Rsjo Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1a^tm3Rsjo mutation (3 available); any Hif1a mutation (50 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:82618 )

• at day 1 of lactation, mammary glands have fewer alveoli, fewer milk granules, and increased trapping of lipid droplets within epithelial cells compared to in wild-type mice

• during lactation, mammary gland wet weight is decreased 50% compared to in wild-type mice

abnormal mammary gland epithelium morphology ( J:82618 )

• by day 15 of pregnancy, mammary gland epithelium lack the lacy appearance of wild-type epithelium

• during lactation, epithelial cells trap milk and fat unlike in wild-type mice

• transplanted mammary epithelium fails to grow in mice expressing the wild-type protein

abnormal mammary gland alveolus morphology ( J:82618 )

• by day 15 of pregnancy, alveoli are smaller than normal with more prominent surrounding connective tissue than in wild-type mice

• alveolar differentiation during pregnancy is blocked

• alveolar lumens are small compared to in wild-type mice and fail to secret milk

• however, cell proliferation is normal

abnormal lactation ( J:82618 )

• female mice fail to secrete sufficient milk to support their offspring, most of whom are runted and die by P15

abnormal milk composition ( J:82618 )

• milk water content is decreased while milk sodium and chloride ion contents are increased at mid-lactation compared to in wild-type mice

abnormal milk sodium level ( J:82618 )

• milk sodium ion content is significantly increased at mid-lactation

homeostasis/metabolism

abnormal milk sodium level ( J:82618 )

• milk sodium ion content is significantly increased at mid-lactation

cardiovascular system

cardiovascular system phenotype ( J:82618 )

N	• microvessel patterning and vascular density in the mammary gland are normal

integument

abnormal mammary gland morphology ( J:82618 )

• at day 1 of lactation, mammary glands have fewer alveoli, fewer milk granules, and increased trapping of lipid droplets within epithelial cells compared to in wild-type mice

• during lactation, mammary gland wet weight is decreased 50% compared to in wild-type mice

abnormal mammary gland epithelium morphology ( J:82618 )

• by day 15 of pregnancy, mammary gland epithelium lack the lacy appearance of wild-type epithelium

• during lactation, epithelial cells trap milk and fat unlike in wild-type mice

• transplanted mammary epithelium fails to grow in mice expressing the wild-type protein

abnormal mammary gland alveolus morphology ( J:82618 )

• by day 15 of pregnancy, alveoli are smaller than normal with more prominent surrounding connective tissue than in wild-type mice

• alveolar differentiation during pregnancy is blocked

• alveolar lumens are small compared to in wild-type mice and fail to secret milk

• however, cell proliferation is normal

abnormal lactation ( J:82618 )

• female mice fail to secrete sufficient milk to support their offspring, most of whom are runted and die by P15

abnormal milk composition ( J:82618 )

• milk water content is decreased while milk sodium and chloride ion contents are increased at mid-lactation compared to in wild-type mice

abnormal milk sodium level ( J:82618 )

• milk sodium ion content is significantly increased at mid-lactation

Allelic Composition	Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0 Tg(MMTV-rtTA)1Lach/0 Tg(tetO-Stat5a)#Mam/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(MMTV-cre)1Mam mutation (1 available)
Tg(MMTV-rtTA)1Lach mutation (0 available)
Tg(tetO-Stat5a)#Mam mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:153755 )

• with doxycycline food during pregnancy female mice develop functional mammary glands during pregnancy and are able to feed their pups

• expanded alveoli lined with differentiated secretory cells, with proteinaceous material and lipid droplets in the lumen after doxycycline treatment

• formation of alveolar structures and functional differentiation of luminal cells after doxycycline treatment

• the mutant mice generate CD61+ luminal progenitor cells during pregnancy to a similar extent as Stat5a/Stat5b^tm2Mam control mice

reproductive system

reproductive system phenotype ( J:153755 )

• with doxycycline food during pregnancy female mice develop functional mammary glands during pregnancy and are able to feed their pups

• expanded alveoli lined with differentiated secretory cells, with proteinaceous material and lipid droplets in the lumen after doxycycline treatment

• formation of alveolar structures and functional differentiation of luminal cells after doxycycline treatment

• the mutant mice generate CD61+ luminal progenitor cells during pregnancy to a similar extent as Stat5a/Stat5b^tm2Mam control mice

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0 Tg(MMTV-rtTA)1Lach/0 Tg(tetO-Stat5a)#Mam/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5a^tm2Mam mutation (1 available); any Stat5a mutation (48 available)
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(MMTV-cre)1Mam mutation (1 available)
Tg(MMTV-rtTA)1Lach mutation (0 available)
Tg(tetO-Stat5a)#Mam mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:153755 )

• with doxycycline food during pregnancy female mice develop functional mammary glands during pregnancy and are able to feed their pups

• expanded alveoli lined with differentiated secretory cells, with proteinaceous material and lipid droplets in the lumen after doxycycline treatment

• formation of alveolar structures and functional differentiation of luminal cells after doxycycline treatment

• the mutant mice generate CD61+ luminal progenitor cells during pregnancy to a similar extent as Stat5a/Stat5b^tm2Mam control mice

reproductive system

reproductive system phenotype ( J:153755 )

• with doxycycline food during pregnancy female mice develop functional mammary glands during pregnancy and are able to feed their pups

• expanded alveoli lined with differentiated secretory cells, with proteinaceous material and lipid droplets in the lumen after doxycycline treatment

• formation of alveolar structures and functional differentiation of luminal cells after doxycycline treatment

• the mutant mice generate CD61+ luminal progenitor cells during pregnancy to a similar extent as Stat5a/Stat5b^tm2Mam control mice

Allelic Composition	Gt(ROSA)26Sor^{tm2(Pik3ca)Egan}/Gt(ROSA)26Sor⁺ Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Pik3ca)Egan} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:170898 )

Allelic Composition	Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺ Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129S6/SvEvTac * FVB/N

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:170898 )

• survival time is reduced compared to mutant mice carrying Tg(MMTV-cre)4Mam

neoplasm

increased tumor incidence ( J:170898 )

• develop a more diverse set of tumors compared to mutant mice carrying Tg(MMTV-cre)4Mam

increased mammary gland tumor incidence ( J:170898 )

• start to develop by 5 months of age in both virgin and multiparous mice

• 42% of mice have palpable mammary tumors at the time of death

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:170898 )

• start to develop by 5 months of age in both virgin and multiparous mice

• 42% of mice have palpable mammary tumors at the time of death

integument

increased mammary gland tumor incidence ( J:170898 )

• start to develop by 5 months of age in both virgin and multiparous mice

• 42% of mice have palpable mammary tumors at the time of death

Allelic Composition	Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5b^tm1Mam mutation (0 available); any Stat5b mutation (33 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during lactation ( J:153755 )

• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy

• produce only a ductal tree with virgin-like characteristics

abnormal mammary gland alveolus morphology ( J:153755 )

• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy

• produce only a ductal tree with virgin-like characteristics

• profoundly reduced amount of luminal progenitors (CD61+) in the luminal cell population (CD24hiCD49flo) in mammary tissue of 12 week-old virgin mice and on day 6 of pregnancy

lactation failure ( J:153755 )

• fail to lactate even after five to six pregnancies

integument

abnormal mammary gland growth during lactation ( J:153755 )

• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy

• produce only a ductal tree with virgin-like characteristics

abnormal mammary gland alveolus morphology ( J:153755 )

• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy

• produce only a ductal tree with virgin-like characteristics

• profoundly reduced amount of luminal progenitors (CD61+) in the luminal cell population (CD24hiCD49flo) in mammary tissue of 12 week-old virgin mice and on day 6 of pregnancy

lactation failure ( J:153755 )

• fail to lactate even after five to six pregnancies

Allelic Composition	Stat5a^tm2Mam/Stat5a^tm2Mam Stat5b^tm1Mam/Stat5b^tm1Mam Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129S6/SvEvTac * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during lactation ( J:153755 )

• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy

• produce only a ductal tree with virgin-like characteristics

abnormal mammary gland alveolus morphology ( J:153755 )

• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy

• produce only a ductal tree with virgin-like characteristics

• profoundly reduced amount of luminal progenitors (CD61+) in the luminal cell population (CD24hiCD49flo) in mammary tissue of 12 week-old virgin mice and on day 6 of pregnancy

lactation failure ( J:153755 )

• fail to lactate even after five to six pregnancies

integument

abnormal mammary gland growth during lactation ( J:153755 )

• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy

• produce only a ductal tree with virgin-like characteristics

abnormal mammary gland alveolus morphology ( J:153755 )

• the epithelial compartment in stem cell-transplanted hosts fail to develop a full alveolar compartment and devoid of milk in the epithelial lumina at term when mated to induce pregnancy

• produce only a ductal tree with virgin-like characteristics

• profoundly reduced amount of luminal progenitors (CD61+) in the luminal cell population (CD24hiCD49flo) in mammary tissue of 12 week-old virgin mice and on day 6 of pregnancy

lactation failure ( J:153755 )

• fail to lactate even after five to six pregnancies

Allelic Composition	Jak2^tm1Kuw/Jak2^tm1Kuw Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak2^tm1Kuw mutation (1 available); any Jak2 mutation (59 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland development ( J:90883 )

• absence of the lobular units that normally reside on the terminal ducts of the tertiary side branches

• lack of alveolar precursors results in impairment development of secretory lobules

abnormal mammary gland growth during pregnancy ( J:90883 )

• mammary epithelia did not undergo alveolar specification during pregnancy

lactation failure ( J:90883 )

• failure of dams to lactate; multiple pregnancies did not restore milk production

reproductive system

abnormal mammary gland growth during pregnancy ( J:90883 )

• mammary epithelia did not undergo alveolar specification during pregnancy

integument

abnormal mammary gland development ( J:90883 )

• absence of the lobular units that normally reside on the terminal ducts of the tertiary side branches

• lack of alveolar precursors results in impairment development of secretory lobules

abnormal mammary gland growth during pregnancy ( J:90883 )

• mammary epithelia did not undergo alveolar specification during pregnancy

lactation failure ( J:90883 )

• failure of dams to lactate; multiple pregnancies did not restore milk production

Allelic Composition	Pparg^tm1Gonz/Pparg^tm1Gonz Tg(MMTV-cre)1Mam/?
Genetic Background	involves: 129X1/SvJ * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pparg^tm1Gonz mutation (0 available); any Pparg mutation (41 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal mammary gland growth during pregnancy ( J:76553 )

• alveolar development induced by pregnancy is impaired

• females cannot nurse pups

female infertility ( J:76553 )

• one third of females are infertile

reduced female fertility ( J:76553 )

• females that can bred have reduced fertility

decreased litter size ( J:76553 )

• females that can bred produce smaller litters

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:76553 )

• alveolar development induced by pregnancy is impaired

• females cannot nurse pups

integument

abnormal mammary gland growth during pregnancy ( J:76553 )

• alveolar development induced by pregnancy is impaired

• females cannot nurse pups

Allelic Composition	Arnt^tm1Gonz/Arnt^tm1Gonz Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129X1/SvJ * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arnt^tm1Gonz mutation (0 available); any Arnt mutation (65 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal mammary gland growth during pregnancy ( J:76280 )

• incomplete development of alveoli probably secondary to impaired ovarian function as tissue transplanted into athymic nude mice develops normally

abnormal ovarian follicle morphology ( J:76280 )

• contain fewer primordial follicles but similar numbers of primary and preantral/antral follicles compared to controls

• however estrus cycle and the levels of estradiol and progesterone are similar to controls

decreased primordial ovarian follicle number ( J:76280 )

• fewer primordial follicles compared to controls

decreased litter size ( J:76280 )

• average litter size is 4 +/- 2 pups

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:76280 )

• incomplete development of alveoli probably secondary to impaired ovarian function as tissue transplanted into athymic nude mice develops normally

abnormal ovarian follicle morphology ( J:76280 )

• contain fewer primordial follicles but similar numbers of primary and preantral/antral follicles compared to controls

• however estrus cycle and the levels of estradiol and progesterone are similar to controls

decreased primordial ovarian follicle number ( J:76280 )

• fewer primordial follicles compared to controls

abnormal lactation ( J:76280 )

• 60% of dams can not support their pups and surviving pups are smaller compared to pups nursed by homozygous dams lacking Cre expression (controls)

integument

abnormal mammary gland growth during pregnancy ( J:76280 )

• incomplete development of alveoli probably secondary to impaired ovarian function as tissue transplanted into athymic nude mice develops normally

abnormal lactation ( J:76280 )

• 60% of dams can not support their pups and surviving pups are smaller compared to pups nursed by homozygous dams lacking Cre expression (controls)

Allelic Composition	Jak1^tm1Kuw/Jak1^tm1Kuw Tg(MMTV-cre)1Mam/0
Genetic Background	involves: 129X1/SvJ * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak1^tm1Kuw mutation (1 available); any Jak1 mutation (50 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:235354 )

• females exhibit a delay in postlactational mammary gland remodeling starting at 3 days post weaning and these abnormalities are still evident after 5 days of involution

• however, females lactate normally, and show normal ductal elongation and branching morphogenesis, and mammary gland alveologenesis during pregnancy

integument

abnormal involution of the mammary gland ( J:235354 )

• females exhibit a delay in postlactational mammary gland remodeling starting at 3 days post weaning and these abnormalities are still evident after 5 days of involution

• however, females lactate normally, and show normal ductal elongation and branching morphogenesis, and mammary gland alveologenesis during pregnancy

Allelic Composition	Id4^tm1Vdr/Id4⁺ Tg(MMTV-cre)1Mam/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id4^tm1Vdr mutation (0 available); any Id4 mutation (9 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:213955 )

• mammary glands from 4-week-old virgin mice display intermediate ductal elongation defects, as determined by the % of fat pad filled

integument

abnormal branching of the mammary ductal tree ( J:213955 )

• mammary glands from 4-week-old virgin mice display intermediate ductal elongation defects, as determined by the % of fat pad filled

Allelic Composition	Id4^tm1Vdr/Id4^tm1Vdr Tg(MMTV-cre)1Mam/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id4^tm1Vdr mutation (0 available); any Id4 mutation (9 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:213955 )

• mammary glands from 4-week-old virgin mice display ductal elongation defects, as determined by the % of fat pad filled relative to control mice

• although ductal elongation is largely restored by 8 weeks of age, complex branching of the ducts is still lacking

• treatment with exogenous beta-estradiol at proestrus and estrus rescues the ductal elongation defects

abnormal mammary gland luminal epithelium morphology ( J:213955 )

• mammary glands from 6-week-old virgin mice show a significant increase in the % of estrogen receptor (ER)-alpha expressing (ERalpha+) and progesterone receptor expressing (PR+) luminal cells relative to those in control mice

• a significantly increased % of ERalpha+ ductal cells is found in the luminal progenitor subset (CD29^loCD24⁺CD49b⁺) but not in the mature luminal subset (CD29^loCD24⁺CD49b^-)

• % of Foxa1 (forkhead box A1) expressing (FoxA1+) cells is significantly increased in the luminal progenitor subset relative to that in control mice

• expression of Ly6a (lymphocyte antigen 6 complex, locus A), an antigen linked to ER and PR expression, is also significantly increased in luminal progenitor cells

• treatment with exogenous beta-estradiol has no significant effect on the % of ERalpha+ ductal cells

abnormal mammary gland myoepithelium morphology ( J:213955 )

• mammary glands from 6-week-old virgin mice show a significant increase in the % of ERalpha+ cells in the mammary stem (MaSC)/basal cell population (CD29^hiCD24⁺) which normally lacks estrogen receptor (Esr1, ERalpha) and progesterone receptor (Pgr, PR) expression

• Foxa1 mRNA and protein levels are dramatically increased in MaSC/basal cells relative to those in control mice

abnormal ovary morphology ( J:213955 )

• at estrus, mice display abnormally-shaped nodular ovaries that contain many large follicles in a loosely connected medulla

increased mature ovarian follicle number ( J:213955 )

• 6-week-old virgin mice show a significant increase in maturing follicle numbers, consistent with an increase in Fshr (follicle stimulating hormone receptor) mRNA levels

increased secondary ovarian follicle number ( J:213955 )

• 6-week-old virgin mice show a significant increase in the number of secondary ovarian follicles per ovary relative to control mice

increased tertiary ovarian follicle number ( J:213955 )

• 6-week-old virgin mice show a significant increase in the number of antral ovarian follicles per ovary relative to control mice

increased atretic ovarian follicle number ( J:213955 )

• 6-week-old virgin mice show a significant increase in the number of atretic (degenerating) ovarian follicles

abnormal ovarian folliculogenesis ( J:213955 )

• 6-week-old virgin mice show a significant increase in the number of secondary, antral and atretic (degenerating) ovarian follicles

• however, the total number of follicles per ovary is similar to that in control mice

abnormal ovarian medulla morphology ( J:213955 )

• at estrus, the ovarian medulla appears loosely connected

reproductive system

abnormal ovary morphology ( J:213955 )

• at estrus, mice display abnormally-shaped nodular ovaries that contain many large follicles in a loosely connected medulla

increased mature ovarian follicle number ( J:213955 )

• 6-week-old virgin mice show a significant increase in maturing follicle numbers, consistent with an increase in Fshr (follicle stimulating hormone receptor) mRNA levels

increased secondary ovarian follicle number ( J:213955 )

• 6-week-old virgin mice show a significant increase in the number of secondary ovarian follicles per ovary relative to control mice

increased tertiary ovarian follicle number ( J:213955 )

• 6-week-old virgin mice show a significant increase in the number of antral ovarian follicles per ovary relative to control mice

increased atretic ovarian follicle number ( J:213955 )

• 6-week-old virgin mice show a significant increase in the number of atretic (degenerating) ovarian follicles

abnormal ovarian folliculogenesis ( J:213955 )

• 6-week-old virgin mice show a significant increase in the number of secondary, antral and atretic (degenerating) ovarian follicles

• however, the total number of follicles per ovary is similar to that in control mice

abnormal ovarian medulla morphology ( J:213955 )

• at estrus, the ovarian medulla appears loosely connected

decreased uterus weight ( J:213955 )

• 6-week-old mice staged at either estrus or proestrus show a significant reduction in uterus wet weight relative to control mice

• treatment with exogenous beta-estradiol restores uterus wet weight to control values

homeostasis/metabolism

decreased circulating estrogen level ( J:213955 )

• 6-week-old mice staged at either estrus or proestrus show a significant reduction in uterus wet weight relative to control mice, indicating reduced levels of circulating estrogen

decreased circulating estradiol level ( J:213955 )

• ovaries from 6-week-old virgin mice exhibit a significant reduction in the expression of key estradiol biosynthesis enzymes relative to control ovaries

integument

abnormal branching of the mammary ductal tree ( J:213955 )

• mammary glands from 4-week-old virgin mice display ductal elongation defects, as determined by the % of fat pad filled relative to control mice

• although ductal elongation is largely restored by 8 weeks of age, complex branching of the ducts is still lacking

• treatment with exogenous beta-estradiol at proestrus and estrus rescues the ductal elongation defects

abnormal mammary gland luminal epithelium morphology ( J:213955 )

• a significantly increased % of ERalpha+ ductal cells is found in the luminal progenitor subset (CD29^loCD24⁺CD49b⁺) but not in the mature luminal subset (CD29^loCD24⁺CD49b^-)

• % of Foxa1 (forkhead box A1) expressing (FoxA1+) cells is significantly increased in the luminal progenitor subset relative to that in control mice

• expression of Ly6a (lymphocyte antigen 6 complex, locus A), an antigen linked to ER and PR expression, is also significantly increased in luminal progenitor cells

• treatment with exogenous beta-estradiol has no significant effect on the % of ERalpha+ ductal cells

abnormal mammary gland myoepithelium morphology ( J:213955 )

• Foxa1 mRNA and protein levels are dramatically increased in MaSC/basal cells relative to those in control mice

Allelic Composition	Pik3ca^tm1Gne/Pik3ca⁺ Tg(MMTV-cre)1Mam/0
Genetic Background	involves: C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3ca^tm1Gne mutation (0 available); any Pik3ca mutation (66 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:193377 )

N	• male mice do not develop tumors in the mammary gland or seminal vesicles

increased mammary gland tumor incidence ( J:193377 )

• thoracic and inguino-abdominal mammary gland tumors with latency dependent on nulliparous or multiparous condition

• however, treatment with PI3K inhibitor inhibits tumor growth

integument

abnormal branching of the mammary ductal tree ( J:193377 )

• precocious lobulo-alveolar development and hyper-branched ductal structures (2-fold increase in ductal branch point) at 12 weeks

• feathery, hyper-branched ductal tree by 50 weeks

increased mammary gland tumor incidence ( J:193377 )

• thoracic and inguino-abdominal mammary gland tumors with latency dependent on nulliparous or multiparous condition

• however, treatment with PI3K inhibitor inhibits tumor growth

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:193377 )

• precocious lobulo-alveolar development and hyper-branched ductal structures (2-fold increase in ductal branch point) at 12 weeks

• feathery, hyper-branched ductal tree by 50 weeks

increased mammary gland tumor incidence ( J:193377 )

• thoracic and inguino-abdominal mammary gland tumors with latency dependent on nulliparous or multiparous condition

• however, treatment with PI3K inhibitor inhibits tumor growth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:193377

Allelic Composition	Becn1^tm1Ebr/Becn1⁺ Tg(MMTV-cre)1Mam/?
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1^tm1Ebr mutation (0 available); any Becn1 mutation (36 available)
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:180916 )

• only 2 of 100 neonates survive through day 1

embryonic lethality during organogenesis, incomplete penetrance ( J:180916 )

• high level of death associated with heart and brain defects at embryonic days 11.5 and 12.5

reproductive system

abnormal primordial ovarian follicle morphology ( J:180916 )

• non uniform distribution of primordial follicles

decreased primordial ovarian follicle number ( J:180916 )

• reduced number of primordial follicles

small ovary ( J:180916 )

cardiovascular system

abnormal heart development ( J:180916 )

• high level of death associated with heart defects at embryonic days 11.5 and 12.5

nervous system

abnormal brain development ( J:180916 )

• high level of death associated with brain defects at embryonic days 11.5 and 12.5

endocrine/exocrine glands

abnormal primordial ovarian follicle morphology ( J:180916 )

• non uniform distribution of primordial follicles

decreased primordial ovarian follicle number ( J:180916 )

• reduced number of primordial follicles

small ovary ( J:180916 )

Allelic Composition	Tg(MMTV-cre)1Mam/?
Genetic Background	involves: FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-cre)1Mam mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during lactation ( J:168531 )

• mammary gland development checked at the end of lactation was highly variable among mice

• cre expression as determined using Gt(ROSA)26Sor^tm1Sor as a reporter is detected in new born females

integument

abnormal mammary gland growth during lactation ( J:168531 )

• mammary gland development checked at the end of lactation was highly variable among mice

• cre expression as determined using Gt(ROSA)26Sor^tm1Sor as a reporter is detected in new born females

cellular

maternal effect ( J:168531 )

• 38% of pups nursed by mothers carrying this transgene survive to weaning

• pups nursed by mothers carrying this transgene are runts, with weights at weaning about 40% that of those nursed by control mothers

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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