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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(GZMB-cre)1Jcb
transgene insertion 1, Joshy Jacob
MGI:2176191
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lef1tm1Hhx/Lef1tm1Hhx
Tcf7tm1Cle/Tcf7tm1Cle
Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+
Tg(GZMB-cre)1Jcb/0 		involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:5447982
cn2
 		Ptentm1Hwu/Ptentm1Hwu
Tg(GZMB-cre)1Jcb/0 		involves: 129S4/SvJae * FVB/N MGI:5013915
cn3
 		Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+
Lef1tm1Hhx/Lef1tm1Hhx
Tg(GZMB-cre)1Jcb/0 		involves: 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:5447981
cn4
 		Fastm1Ach/Fastm1Ach
Tg(GZMB-cre)1Jcb/? 		involves: C57BL/6 * FVB/N MGI:3720607


Genotype
MGI:5447982
cn1
Allelic
Composition		 Lef1tm1Hhx/Lef1tm1Hhx
Tcf7tm1Cle/Tcf7tm1Cle
Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+
Tg(GZMB-cre)1Jcb/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2Sho mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Lef1tm1Hhx mutation (2 available); any Lef1 mutation (43 available)
Tcf7tm1Cle mutation (0 available); any Tcf7 mutation (26 available)
Tg(GZMB-cre)1Jcb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:189838 )
• decreased CD8+ effector T cells in the peripheral blood lymphocytes compared with control mice and more so than in Tcf7tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin
• decreased memory precursors and memory CD8+ T cells compared with control mice and more so than in Tcf7tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin
abnormal memory T cell physiology ( J:189838 )
• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice
decreased tumor necrosis factor secretion ( J:189838 )
• from CD8+ effector T cells following infection with actA- L. monocytogenes-expressing ovalbumin

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:189838 )
• decreased CD8+ effector T cells in the peripheral blood lymphocytes compared with control mice and more so than in Tcf7tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin
• decreased memory precursors and memory CD8+ T cells compared with control mice and more so than in Tcf7tm1Cle homozygotes following infection with actA- L. monocytogenes-expressing ovalbumin
abnormal memory T cell physiology ( J:189838 )
• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice




Genotype
MGI:5013915
cn2
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Tg(GZMB-cre)1Jcb/0
Genetic
Background		 involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(GZMB-cre)1Jcb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD8-positive, alpha-beta T cell physiology ( J:164425 )
• mutants infected with lymphocytic choriomeningitis virus (LCMV) to induce T-cell activation and thus cre-expression exhibit better survival of effector CD8 T cells under serum-starvation conditions compared to controls, but only show modest effects on the expansion and contraction of effector CD8 T cells
• clonal burst of mutant effector CD8 T cells is about 1/2 that of wild-type controls and there is a slight, but not significant reduction in the number of memory T cells that form in lymphoid and nonlymphoid tissues
decreased interleukin-2 secretion ( J:164425 )
• production of IL-2 by CD8 T cells is diminished in mutants infected with LCMV to induce T-cell activation and thus cre-expression

hematopoietic system
abnormal CD8-positive, alpha-beta T cell physiology ( J:164425 )
• mutants infected with lymphocytic choriomeningitis virus (LCMV) to induce T-cell activation and thus cre-expression exhibit better survival of effector CD8 T cells under serum-starvation conditions compared to controls, but only show modest effects on the expansion and contraction of effector CD8 T cells
• clonal burst of mutant effector CD8 T cells is about 1/2 that of wild-type controls and there is a slight, but not significant reduction in the number of memory T cells that form in lymphoid and nonlymphoid tissues




Genotype
MGI:5447981
cn3
Allelic
Composition		 Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+
Lef1tm1Hhx/Lef1tm1Hhx
Tg(GZMB-cre)1Jcb/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2Sho mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Lef1tm1Hhx mutation (2 available); any Lef1 mutation (43 available)
Tg(GZMB-cre)1Jcb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:189838 )
• decreased CD8+ effector T cells in the peripheral blood lymphocytes compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin
• decreased CD8+ memory precursors and memory T cells compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin
abnormal memory T cell physiology ( J:189838 )
• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:189838 )
• decreased CD8+ effector T cells in the peripheral blood lymphocytes compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin
• decreased CD8+ memory precursors and memory T cells compared with control mice following infection with actA- L. monocytogenes-expressing ovalbumin
abnormal memory T cell physiology ( J:189838 )
• following infection with actA- L. monocytogenes-expressing ovalbumin, memory CD8+ T cells exhibit impaired maturation, function and recall response compared with control mice




Genotype
MGI:3720607
cn4
Allelic
Composition		 Fastm1Ach/Fastm1Ach
Tg(GZMB-cre)1Jcb/?
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Ach mutation (0 available); any Fas mutation (82 available)
Tg(GZMB-cre)1Jcb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased double-positive T cell number ( J:123556 )
• CD3+B220+ double positive cells accumulate

hematopoietic system
increased double-positive T cell number ( J:123556 )
• CD3+B220+ double positive cells accumulate




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory