Analysis Tools|
Allele Symbol Allele Name Allele ID |
Emx1tm1(cre)Yql targeted mutation 1, Yuqing Li MGI:2176219 |
||||||||||||||||||||||||||||||||||||
| Summary |
8 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• Background Sensitivity: the absence of a corpus collosum was noted on a segregating 129/Sv x C57BL/6 genetic background; however, no such phenotype was reported when the mutation was made congenic on a C57BL/6 background
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• females display poor nursing behavior
• 80% do not nurse at all and abandon pups
|
|
• increased sensitivity to PTZ induced seizures
• 83% die within 60 minutes of PTZ injection compared to 58% mortality in controls
• significantly higher numbers of phase I and phase II seizures
• duration of seizures increased for phase I
• 2X as much time in seizure as controls
|
|
• males significantly smaller than littermates
|
|
• increased sensitivity to PTZ induced seizures
• 83% die within 60 minutes of PTZ injection compared to 58% mortality in controls
• significantly higher numbers of phase I and phase II seizures
• duration of seizures increased for phase I
• 2X as much time in seizure as controls
|
|
• as a result of missing hippocampal structures
|
|
• lack hippocampal commissure
|
|
• CA1, CA2, CA3 all not detected
|
|
• impaired cortical development, failure of lobes to extend caudally
• adult brain similar in appearance to perinatal brain
• thinner cortex
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit subtle to inapparent abnormalities in the cortical hem at E12.5
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• strong reduction in gephyrin cluster numbers in the hippocampus at P40, P60 and P130
• however, clustering is unaffected in other areas of the brain
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
• impaired
|
|
|
• in a Morris water maze
|
|
|
• in a Morris water maze
|
|
|
• increased depression-like behavior
|
|
|
• mice exhibit increased latency to feed in a novelty suppressed feed test compared with wild-type mice
|
|
|
• slight
|
|
|
• at E18, Cux1+ neurons are mislocalized in the deep layers of the lateral somatosensory cortex compared to in wild-type mice
|
|
|
• most cultured cortical neurons remain multipolar shape unlike control neurons
• axonal branching in the somatosensory cortex and the corticothalamic tracts is increased compared with control mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• on a beam-walking test, 71% of mice exhibit more falls than wild-type mice
• however, mice perform normally in a rotarod test
|
|
• the hind base of male mice is smaller than in wild-type mice
|
|
• mice exhibit hyperactivity in an open-field test
|
| N |
• the cerebral cortex and dopamine metabolite levels are normal
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit a 219% increase of slips in the beam walking test
• however, mice do not show a deficit in the rotarod test
|
|
• in the continuous open field test, mice show an increase in activity level during the light phase but not dark phase indicating a rest-phase specific motor restlessness
• however, mice exhibit a similar level of total distance traveled in a 30 min open field test as controls and similar wheel running activity during both the light and dark phase as in controls
|
|
• sleep analysis indicates an increased probability of waking in the light phase but not dark phase
|
|
• mice exhibit lower sensitivity to the heat stimuli than controls in the tail-flick test, indicating decreased thermal sensory perception
|
|
• mice exhibit thinner cortical layers in the posterior primary motor cortex
|
|
• mice exhibit thinner cortical layers in both the anterior and posterior part of the primary somatosensory cortex representing the hindlimb
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| restless legs syndrome | DOID:0050425 |
OMIM:PS102300 |
J:282582 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• behavior in Morris water maze, elevated plus maze, open field and context-dependent and cue-dependent fear conditioning tests
• locomotor behavior in Morris water maze, elevated plus maze and open field tests
|
|
• significantly lower cumulative doses of PTZ and latency to induce onset of generalized tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures
• significantly longer intervals between minimal and tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures
|
|
• many cells positive for Cux1 (marker for cerebral cortex layers II-IV) remained in the intermediate zone (IZ) at age P2
|
|
• significantly lower cumulative doses of PTZ and latency to induce onset of generalized tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures
• significantly longer intervals between minimal and tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures
|
|
• many cells positive for Cux1 (marker for cerebral cortex layers II-IV) remained in the intermediate zone (IZ) at age P2
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 10/29/2024 MGI 6.24 |
|
|
|
||
