Analysis Tools|
Allele Symbol Allele Name Allele ID |
Emx1tm1(cre)Yql targeted mutation 1, Yuqing Li MGI:2176219 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Background Sensitivity: the absence of a corpus collosum was noted on a segregating 129/Sv x C57BL/6 genetic background; however, no such phenotype was reported when the mutation was made congenic on a C57BL/6 background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• females display poor nursing behavior
• 80% do not nurse at all and abandon pups
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• increased sensitivity to PTZ induced seizures
• 83% die within 60 minutes of PTZ injection compared to 58% mortality in controls
• significantly higher numbers of phase I and phase II seizures
• duration of seizures increased for phase I
• 2X as much time in seizure as controls
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• males significantly smaller than littermates
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• increased sensitivity to PTZ induced seizures
• 83% die within 60 minutes of PTZ injection compared to 58% mortality in controls
• significantly higher numbers of phase I and phase II seizures
• duration of seizures increased for phase I
• 2X as much time in seizure as controls
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• as a result of missing hippocampal structures
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• lack hippocampal commissure
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• CA1, CA2, CA3 all not detected
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• impaired cortical development, failure of lobes to extend caudally
• adult brain similar in appearance to perinatal brain
• thinner cortex
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit subtle to inapparent abnormalities in the cortical hem at E12.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• strong reduction in gephyrin cluster numbers in the hippocampus at P40, P60 and P130
• however, clustering is unaffected in other areas of the brain
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• impaired
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• in a Morris water maze
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• in a Morris water maze
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• increased depression-like behavior
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• mice exhibit increased latency to feed in a novelty suppressed feed test compared with wild-type mice
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• slight
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• at E18, Cux1+ neurons are mislocalized in the deep layers of the lateral somatosensory cortex compared to in wild-type mice
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• most cultured cortical neurons remain multipolar shape unlike control neurons
• axonal branching in the somatosensory cortex and the corticothalamic tracts is increased compared with control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• on a beam-walking test, 71% of mice exhibit more falls than wild-type mice
• however, mice perform normally in a rotarod test
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• the hind base of male mice is smaller than in wild-type mice
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• mice exhibit hyperactivity in an open-field test
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| N |
• the cerebral cortex and dopamine metabolite levels are normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a 219% increase of slips in the beam walking test
• however, mice do not show a deficit in the rotarod test
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• in the continuous open field test, mice show an increase in activity level during the light phase but not dark phase indicating a rest-phase specific motor restlessness
• however, mice exhibit a similar level of total distance traveled in a 30 min open field test as controls and similar wheel running activity during both the light and dark phase as in controls
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• sleep analysis indicates an increased probability of waking in the light phase but not dark phase
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• mice exhibit lower sensitivity to the heat stimuli than controls in the tail-flick test, indicating decreased thermal sensory perception
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• mice exhibit thinner cortical layers in the posterior primary motor cortex
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• mice exhibit thinner cortical layers in both the anterior and posterior part of the primary somatosensory cortex representing the hindlimb
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| restless legs syndrome | DOID:0050425 |
OMIM:PS102300 |
J:282582 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• behavior in Morris water maze, elevated plus maze, open field and context-dependent and cue-dependent fear conditioning tests
• locomotor behavior in Morris water maze, elevated plus maze and open field tests
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• significantly lower cumulative doses of PTZ and latency to induce onset of generalized tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures
• significantly longer intervals between minimal and tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures
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• many cells positive for Cux1 (marker for cerebral cortex layers II-IV) remained in the intermediate zone (IZ) at age P2
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• significantly lower cumulative doses of PTZ and latency to induce onset of generalized tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures
• significantly longer intervals between minimal and tonic-clonic seizures with pentylenetetrazol (PTZ)-induced seizures
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• many cells positive for Cux1 (marker for cerebral cortex layers II-IV) remained in the intermediate zone (IZ) at age P2
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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