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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk10tm1Flv
targeted mutation 1, Richard A Flavell
MGI:2176237
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapk10tm1Flv/Mapk10tm1Flv B6.129S1-Mapk10tm1Flv MGI:3580019
hm2
 		Mapk10tm1Flv/Mapk10tm1Flv involves: 129S1/Sv MGI:3580018
cx3
 		Mapk10tm1Flv/Mapk10tm1Flv
Mapk9tm1Flv/Mapk9tm1Flv 		B6.129S-Mapk9tm1Flv Mapk10tm1Flv MGI:3580020
cx4
 		Mapk10tm1Flv/Mapk10tm1Flv
Mapk8tm1Flv/Mapk8tm1Flv 		involves: 129S1/Sv MGI:3690778
cx5
 		Mapk10tm1Flv/Mapk10tm1Flv
Mapk9tm1Flv/Mapk9tm1Flv 		involves: 129S1/Sv * 129S2/SvPas MGI:3690780


Genotype
MGI:3580019
hm1
Allelic
Composition		 Mapk10tm1Flv/Mapk10tm1Flv
Genetic
Background		 B6.129S1-Mapk10tm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk10tm1Flv mutation (2 available); any Mapk10 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:87428 )
• improved performance over controls after treatment with MPTP in a rotorod test but only at low speeds

nervous system
decreased susceptibility to dopaminergic neuron neurotoxicity ( J:87428 )
• increased resistance to MPTP induced Parkinson's disease
abnormal somatic motor system morphology ( J:96192 )
• 3 fold improvement in neuron survival in the facial motor nucleus after axotomy (37% survive)
• improved neuron survival in dorsal root ganglia as well

homeostasis/metabolism
decreased susceptibility to dopaminergic neuron neurotoxicity ( J:87428 )
• increased resistance to MPTP induced Parkinson's disease
abnormal dopamine level ( J:87428 )
• reduced dopamine levels but not as much as seen in controls after MPTP treatment

cellular
decreased susceptibility to dopaminergic neuron neurotoxicity ( J:87428 )
• increased resistance to MPTP induced Parkinson's disease




Genotype
MGI:3580018
hm2
Allelic
Composition		 Mapk10tm1Flv/Mapk10tm1Flv
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk10tm1Flv mutation (2 available); any Mapk10 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased susceptibility to pharmacologically induced seizures ( J:43658 )
• resistant to seizures induced by low doses (30mg/kg) of kainic acid
• remain sensitive to pentetrazole induced seizures
• higher doses of kainic acid (45mg/kg)induced seizures similar to those seen in controls but survival was much better, 60% of controls killed by this dose

nervous system
decreased susceptibility to pharmacologically induced seizures ( J:43658 )
• resistant to seizures induced by low doses (30mg/kg) of kainic acid
• remain sensitive to pentetrazole induced seizures
• higher doses of kainic acid (45mg/kg)induced seizures similar to those seen in controls but survival was much better, 60% of controls killed by this dose
decreased neuron apoptosis ( J:124252 )
• lower levels of apoptosis (35%) are induced in primary cortical neuron cultures than in wild-type neurons (55%) after 24 hours of treatment with 25 um Abeta25-35 peptide
• similar results are obtained for treated cultured hippocampal neurons or cortical neurons treated with Abeta 1-40
decreased susceptibility to neuronal excitotoxicity ( J:43658 )
• resistant to damage seen in pyramidal neurons of CA1 of controls when treated with kainic acid
• resistant to hippocampal cell damage which is evident at 30mg/kg kainic acid dose in control mice; limited damage seen at a 45mg/kg dos

cardiovascular system
cardiovascular system phenotype ( J:108253 )
N
• exhibit no difference in response to pressure overload compared to wild-type

cellular
abnormal cell death ( J:117956 )
• in mutants, corticospinal neurons are resistant to lesion-induced cell death whereas ~40% of wild-type CSN die after CSN deafferentation at 4 months of age
decreased neuron apoptosis ( J:124252 )
• lower levels of apoptosis (35%) are induced in primary cortical neuron cultures than in wild-type neurons (55%) after 24 hours of treatment with 25 um Abeta25-35 peptide
• similar results are obtained for treated cultured hippocampal neurons or cortical neurons treated with Abeta 1-40
decreased susceptibility to neuronal excitotoxicity ( J:43658 )
• resistant to damage seen in pyramidal neurons of CA1 of controls when treated with kainic acid
• resistant to hippocampal cell damage which is evident at 30mg/kg kainic acid dose in control mice; limited damage seen at a 45mg/kg dos

homeostasis/metabolism
decreased susceptibility to neuronal excitotoxicity ( J:43658 )
• resistant to damage seen in pyramidal neurons of CA1 of controls when treated with kainic acid
• resistant to hippocampal cell damage which is evident at 30mg/kg kainic acid dose in control mice; limited damage seen at a 45mg/kg dos




Genotype
MGI:3580020
cx3
Allelic
Composition		 Mapk10tm1Flv/Mapk10tm1Flv
Mapk9tm1Flv/Mapk9tm1Flv
Genetic
Background		 B6.129S-Mapk9tm1Flv Mapk10tm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk10tm1Flv mutation (2 available); any Mapk10 mutation (37 available)
Mapk9tm1Flv mutation (2 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased susceptibility to dopaminergic neuron neurotoxicity ( J:87428 )
• resistance to MPTP-induced Parkinson's disease
abnormal somatic motor system morphology ( J:96192 )
• much improved neuron survival in the facial motor nucleus after axotomy (52% survive)

behavior/neurological
behavior/neurological phenotype ( J:87428 )
N
• MPTP treatment had no effect on rotarod performance at any speed

homeostasis/metabolism
decreased susceptibility to dopaminergic neuron neurotoxicity ( J:87428 )
• resistance to MPTP-induced Parkinson's disease
abnormal dopamine level ( J:87428 )
• somewhat reduced dopamine levels after MTP treatment

cellular
decreased susceptibility to dopaminergic neuron neurotoxicity ( J:87428 )
• resistance to MPTP-induced Parkinson's disease




Genotype
MGI:3690778
cx4
Allelic
Composition		 Mapk10tm1Flv/Mapk10tm1Flv
Mapk8tm1Flv/Mapk8tm1Flv
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk10tm1Flv mutation (2 available); any Mapk10 mutation (37 available)
Mapk8tm1Flv mutation (3 available); any Mapk8 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:54653 )
N
• appear healthy and do not exhibit exencephaly or abnormal apoptosis during brain development




Genotype
MGI:3690780
cx5
Allelic
Composition		 Mapk10tm1Flv/Mapk10tm1Flv
Mapk9tm1Flv/Mapk9tm1Flv
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk10tm1Flv mutation (2 available); any Mapk10 mutation (37 available)
Mapk9tm1Flv mutation (2 available); any Mapk9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:54653 )
N
• do not exhibit exencephaly or show abnormal apoptosis during brain development




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory