Analysis Tools
growth/size/body
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• total fat content of mice is 58% less while protein content is 21% higher than in controls
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• mice are resistant to obesity caused by eating a high-fat diet for 3.5 months with total fat content being 50% less than controls
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adipose tissue
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• subcutaneous fat weight is about half that of controls
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• total fat content of mice is 58% less than controls
• MRI analysis finds total adipocyte content is 36% less than controls
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• lipid droplet size in brown fat cells is much smaller than in controls
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• white fat cell size is 62% smaller than controls
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• epididymal fat pads weigh about 4-fold less than controls
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• interscapular fat pads weight about half that of controls
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• fat pads weigh 37%-74% less than controls
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behavior/neurological
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• mice consume 0.429 kcal/day/g body weight compared to 0.332 kcal/day/g body weight for controls
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homeostasis/metabolism
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• mice are resistant to obesity caused by eating a high-fat diet for 3.5 months with total fat content being 50% less than controls
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• fasted mice drop body temperature much more quickly than controls in response to a cold environment
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• mice have decreased levels of circulating leptins with males having 2.26 ng/ml versus 3.64 ng/ml in controls, and female mice having 1.78 ng/ml versus 3.02 ng/ml for controls
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• rises in ketone bodies caused be fasting are attenuated in these mice
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• non-esterified free fatty acids (NEFA) do not increase in circulation after fasting compared to a doubling in level that occurs to controls
• NEFA levels also do not increase in response to isoproterenol treatment
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• mice on a regular chow diet consume 11% more oxygen than controls
• mice fed a high fat diet consume 20% more oxygen than diet-matched controls
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• rises in glycerol in response to beta-adrenergic agonists are attenuated in these mice
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• lipase activity of subcutaneous fat extracts is 287% greater than controls and extracts from epididymal fat is 652% greater than controls
• rises in glycerol or NEFA levels in response to beta-adrenergic agonists is attenuated compared to controls suggesting that adipocytes have near-maximal lipolysis under basal conditions
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muscle
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• gastrocnemius muscle of mutants weighs 7.8% more than that of controls
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integument
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• subcutaneous fat weight is about half that of controls
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limbs/digits/tail
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• gastrocnemius muscle of mutants weighs 7.8% more than that of controls
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