Phenotypes associated with this allele

• Allele Symbol: Plin1^tm1Cdl
• Allele Name: targeted mutation 1, Constantine D Londos
• Allele ID: MGI:2176249
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plin1^tm1Cdl/Plin1^tm1Cdl	involves: 129S6/SvEvTac * C57BL/6	MGI:3849176

Genotype
MGI:3849176

hm1

• Allelic Composition: Plin1^tm1Cdl/Plin1^tm1Cdl
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:69629 )

N • weight is normal on a normal diet

increased lean body mass ( J:69629 )

• increased 10% over controls

adipose tissue

decreased subcutaneous adipose tissue amount ( J:69629 )

decreased total body fat amount ( J:69629 )

• substantially decreased

decreased brown fat lipid droplet number ( J:69629 )

• no visible fat droplets in brown fat cells

abnormal fat pad morphology ( J:69629 )

decreased epididymal fat pad weight ( J:69629 )

• epididymal fat pad weight remains 25% of normal after 14 weeks on a high fat diet even though this weight is increased 80% over the weight on a normal diet

decreased inguinal fat pad weight ( J:69629 )

decreased retroperitoneal fat pad weight ( J:69629 )

decreased parametrial fat pad weight ( J:69629 )

decreased total fat pad weight ( J:69629 )

• males show a 72% reduction in the combined epididymal, retroperitoneal, inguinal fat pad total weight

• females show a 63% reduction in the combined parametrial, retroperitoneal, inguinal fat pad total weight

• occasional animals with no visible fat pads

liver/biliary system

abnormal liver morphology ( J:69629 )

• no lipid depositions in the liver

homeostasis/metabolism

increased circulating leptin level ( J:69629 )

• greater increase in plasma leptin as fat mass increases than seen in control mice

increased oxygen consumption ( J:69629 )

• oxygen consumption at thermoneutrality (30C) is 16% greater than in controls

• oxygen consumption at 24C is normal

abnormal glucose homeostasis ( J:69629 )

increased circulating insulin level ( J:69629 )

• plasma insulin levels are elevated in non fasted females

impaired glucose tolerance ( J:69629 )

• glucose intolerance develops in mice weighing over 30g

abnormal lipolysis ( J:69629 )

enhanced lipolysis ( J:69629 )

• basal glycerol or free fatty acid release is about 4 fold greater than for controls

impaired lipolysis ( J:69629 )

• stimulated glycerol release only about 30% of control level

• stimulated glycerol or free fatty acid release shows a 3 fold increase compared to the 30 fold increase in control mice

integument

decreased subcutaneous adipose tissue amount ( J:69629 )